Sugi Variant

Sugi Variant/PPP2R5C

PPP2R5C — 137 ClinVar variants

All ClinVar germline PPP2R5C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 4 Conflicting · 14 Benign · 4 Benign/Likely benign · 34 Likely benign · 78 Uncertain significance

Full PPP2R5C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 58

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 45

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All PPP2R5C variants

Pathogenic 1

Likely pathogenic 2

Conflicting classifications of pathogenicity 4

Benign 14

Benign/Likely benign 4

Likely benign 34

Uncertain significance 78