PPP4C — 6 ClinVar variants
All ClinVar germline PPP4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
6 Uncertain significance
Full PPP4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All PPP4C variants
Uncertain significance 6
- p.Arg107His Single submitter ⚠
- p.Ile11Met Single submitter
- p.Ile231Met Single submitter ⚠
- p.Leu279Val Single submitter ⚠
- p.Ser170Ala Single submitter ⚠
- p.Thr204Ser Single submitter ⚠