PRAME — 97 ClinVar variants
All ClinVar germline PRAME variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
4 Benign · 8 Likely benign · 85 Uncertain significance
Full PRAME gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 69
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRAME p.Ala168Thr Uncertain significance Single submitter
- PRAME p.Ala250Val Uncertain significance Single submitter
- PRAME p.Ala286Thr Uncertain significance Single submitter
- PRAME p.Ala44Thr Uncertain significance Single submitter
- PRAME p.Ala465Thr Uncertain significance Single submitter
- PRAME p.Arg113Cys Uncertain significance Single submitter
- PRAME p.Arg113His Uncertain significance Single submitter
- PRAME p.Arg125Gln Uncertain significance Single submitter
- PRAME p.Arg140Gly Uncertain significance Single submitter
- PRAME p.Arg159Gln Uncertain significance Single submitter
- PRAME p.Arg263His Uncertain significance Single submitter
- PRAME p.Arg310Gly Uncertain significance Single submitter
- PRAME p.Arg312His Uncertain significance Single submitter
- PRAME p.Arg333Gln Uncertain significance Single submitter
- PRAME p.Arg375Gly Uncertain significance Single submitter
- PRAME p.Arg459Ser Uncertain significance Single submitter
- PRAME p.Arg476Trp Uncertain significance Single submitter
- PRAME p.Asn127Ile Uncertain significance Single submitter
- PRAME p.Asn435Ser Uncertain significance Single submitter
- PRAME p.Asp233Tyr Uncertain significance Single submitter
- PRAME p.Asp338Ala Uncertain significance Single submitter
- PRAME p.Asp382Asn Uncertain significance Single submitter
- PRAME p.Cys188Arg Uncertain significance Single submitter
- PRAME p.Cys80Ser Uncertain significance Single submitter
- PRAME p.Gln231Arg Uncertain significance Single submitter
- PRAME p.Glu185Lys Uncertain significance Single submitter
- PRAME p.Glu281Lys Uncertain significance Single submitter
- PRAME p.Glu28Asp Uncertain significance Single submitter
- PRAME p.Glu46Lys Uncertain significance Single submitter
- PRAME p.Gly31Val Uncertain significance Single submitter
- PRAME p.Gly337Arg Uncertain significance Single submitter
- PRAME p.Gly84Arg Uncertain significance Single submitter
- PRAME p.His129Tyr Uncertain significance Single submitter
- PRAME p.His271Gln Uncertain significance Single submitter
- PRAME p.His489Tyr Uncertain significance Single submitter
- PRAME p.Ile42Val Uncertain significance Single submitter
- PRAME p.Ile431Met Uncertain significance Single submitter
- PRAME p.Leu143Met Uncertain significance Single submitter
- PRAME p.Leu266Phe Uncertain significance Single submitter
- PRAME p.Leu316Phe Uncertain significance Single submitter
- PRAME p.Leu351Pro Uncertain significance Single submitter
- PRAME p.Leu455Phe Uncertain significance Single submitter
- PRAME p.Leu470Val Uncertain significance Single submitter
- PRAME p.Leu92Phe Uncertain significance Single submitter
- PRAME p.Lys224Arg Uncertain significance Single submitter
- PRAME p.Lys70Arg Uncertain significance Single submitter
- PRAME p.Met218Ile Uncertain significance Single submitter
- PRAME p.Met360Leu Uncertain significance Single submitter
- PRAME p.Met360Val Uncertain significance Single submitter
- PRAME p.Phe172Val Uncertain significance Single submitter
- PRAME p.Phe495Cys Uncertain significance Single submitter
- PRAME p.Pro278Leu Uncertain significance Single submitter
- PRAME p.Pro323Ala Uncertain significance Single submitter
- PRAME p.Pro346Arg Uncertain significance Single submitter
- PRAME p.Pro498Leu Uncertain significance Single submitter
- PRAME p.Pro504Ser Uncertain significance Single submitter
- PRAME p.Ser294Arg Uncertain significance Single submitter
- PRAME p.Ser328Thr Uncertain significance Single submitter
- PRAME p.Ser335Leu Uncertain significance Single submitter
- PRAME p.Thr454Ser Uncertain significance Single submitter
- PRAME p.Thr79Ile Uncertain significance Single submitter
- PRAME p.Val112Asp Uncertain significance Single submitter
- PRAME p.Val121Ala Uncertain significance Single submitter
- PRAME p.Val135Ile Uncertain significance Single submitter
- PRAME p.Val230Met Uncertain significance Single submitter
- PRAME p.Val27Met Uncertain significance Single submitter
- PRAME p.Val339Ala Uncertain significance Single submitter
- PRAME p.Val353Ala Uncertain significance Single submitter
- PRAME p.Val364Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- PRAME p.Ala250Glu Uncertain significance Single submitter
- PRAME p.Arg263Gly Uncertain significance Single submitter
- PRAME p.Cys505Arg Uncertain significance Single submitter
- PRAME p.Glu28Lys Uncertain significance Single submitter
- PRAME p.Gly257Asp Uncertain significance Single submitter
- PRAME p.Leu119Pro Uncertain significance Single submitter
- PRAME p.Leu206Pro Uncertain significance Single submitter
- PRAME p.Leu265Arg Uncertain significance Single submitter
- PRAME p.Leu265Val Uncertain significance Single submitter
- PRAME p.Leu334His Uncertain significance Single submitter
- PRAME p.Lys160Glu Uncertain significance Single submitter
- PRAME p.Phe495Ser Uncertain significance Single submitter
- PRAME p.Phe57Leu Uncertain significance Single submitter
- PRAME p.Pro23Leu Uncertain significance Single submitter
- PRAME p.Pro82Ser Uncertain significance Single submitter
All PRAME variants
Benign 4
- p.Asn204Ser Multiple submitters
- p.Leu256= Multiple submitters
- p.Ser421= Multiple submitters
- p.Trp7Arg Multiple submitters
Likely benign 8
- p.Arg201Gln Single submitter
- p.Arg5His Single submitter
- p.Gln424Glu Single submitter
- p.Ile173Thr Single submitter
- p.Met340Ile Single submitter
- p.Ser165Arg Single submitter
- p.Thr391Met Single submitter
- p.Val320Leu Single submitter
Uncertain significance 85
- p.Ala168Thr Single submitter ⚠
- p.Ala250Glu Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala286Thr Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Ala465Thr Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg125Gln Single submitter ⚠
- p.Arg140Gly Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg263Gly Single submitter ⚠
- p.Arg263His Single submitter ⚠
- p.Arg310Gly Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg333Gln Single submitter ⚠
- p.Arg375Gly Single submitter ⚠
- p.Arg459Ser Single submitter ⚠
- p.Arg476Trp Single submitter ⚠
- p.Asn127Ile Single submitter ⚠
- p.Asn435Ser Single submitter ⚠
- p.Asp233Tyr Single submitter ⚠
- p.Asp338Ala Single submitter ⚠
- p.Asp382Asn Single submitter ⚠
- p.Cys188Arg Single submitter ⚠
- p.Cys505Arg Single submitter ⚠
- p.Cys80Ser Single submitter ⚠
- p.Gln231Arg Single submitter ⚠
- p.Glu185Lys Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu28Asp Single submitter ⚠
- p.Glu28Lys Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Gly257Asp Single submitter ⚠
- p.Gly31Val Single submitter ⚠
- p.Gly337Arg Single submitter ⚠
- p.Gly84Arg Single submitter ⚠
- p.His129Tyr Single submitter ⚠
- p.His271Gln Single submitter ⚠
- p.His489Tyr Single submitter ⚠
- p.Ile42Val Single submitter ⚠
- p.Ile431Met Single submitter ⚠
- p.Leu119Pro Single submitter ⚠
- p.Leu143Met Single submitter ⚠
- p.Leu206Pro Single submitter ⚠
- p.Leu265Arg Single submitter ⚠
- p.Leu265Val Single submitter ⚠
- p.Leu266Phe Single submitter ⚠
- p.Leu316Phe Single submitter ⚠
- p.Leu334His Single submitter ⚠
- p.Leu351Pro Single submitter ⚠
- p.Leu455Phe Single submitter ⚠
- p.Leu470Val Single submitter ⚠
- p.Leu81Phe Single submitter
- p.Leu92Phe Single submitter ⚠
- p.Lys160Glu Single submitter ⚠
- p.Lys224Arg Single submitter ⚠
- p.Lys70Arg Single submitter ⚠
- p.Met218Ile Single submitter ⚠
- p.Met360Leu Single submitter ⚠
- p.Met360Val Single submitter ⚠
- p.Phe172Val Single submitter ⚠
- p.Phe495Cys Single submitter ⚠
- p.Phe495Ser Single submitter ⚠
- p.Phe57Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro278Leu Single submitter ⚠
- p.Pro323Ala Single submitter ⚠
- p.Pro346Arg Single submitter ⚠
- p.Pro498Leu Single submitter ⚠
- p.Pro504Ser Single submitter ⚠
- p.Pro82Ser Single submitter ⚠
- p.Ser294Arg Single submitter ⚠
- p.Ser328Thr Single submitter ⚠
- p.Ser335Leu Single submitter ⚠
- p.Thr454Ser Single submitter ⚠
- p.Thr79Ile Single submitter ⚠
- p.Val112Asp Single submitter ⚠
- p.Val121Ala Single submitter ⚠
- p.Val135Ile Single submitter ⚠
- p.Val230Met Single submitter ⚠
- p.Val27Met Single submitter ⚠
- p.Val339Ala Single submitter ⚠
- p.Val353Ala Single submitter ⚠
- p.Val364Ile Single submitter ⚠