PRCP — 73 ClinVar variants
All ClinVar germline PRCP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
2 Benign · 1 Likely benign · 70 Uncertain significance
Full PRCP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRCP p.Ala201Glu Uncertain significance Single submitter
- PRCP p.Ala260Gly Uncertain significance Single submitter
- PRCP p.Arg163Lys Uncertain significance Single submitter
- PRCP p.Arg227Ser Uncertain significance Single submitter
- PRCP p.Arg239Ser Uncertain significance Single submitter
- PRCP p.Asn296Tyr Uncertain significance Single submitter
- PRCP p.Asn315Thr Uncertain significance Single submitter
- PRCP p.Asn415Asp Uncertain significance Single submitter
- PRCP p.Asn82Lys Uncertain significance Single submitter
- PRCP p.Asp271Gly Uncertain significance Single submitter
- PRCP p.Asp290Gly Uncertain significance Single submitter
- PRCP p.Asp377Asn Uncertain significance Single submitter
- PRCP p.Cys394Ser Uncertain significance Single submitter
- PRCP p.Gln208His Uncertain significance Single submitter
- PRCP p.Gln255Arg Uncertain significance Single submitter
- PRCP p.Gln55Arg Uncertain significance Single submitter
- PRCP p.Glu112Lys Uncertain significance Single submitter
- PRCP p.Gly178Asp Uncertain significance Single submitter
- PRCP p.Gly230Ser Uncertain significance Single submitter
- PRCP p.Gly413Val Uncertain significance Single submitter
- PRCP p.Gly435Asp Uncertain significance Single submitter
- PRCP p.His383Arg Uncertain significance Single submitter
- PRCP p.His455Arg Uncertain significance Single submitter
- PRCP p.His480Arg Uncertain significance Single submitter
- PRCP p.His496Arg Uncertain significance Single submitter
- PRCP p.Ile422Val Uncertain significance Single submitter
- PRCP p.Leu129Phe Uncertain significance Single submitter
- PRCP p.Leu29Arg Uncertain significance Single submitter
- PRCP p.Leu331Val Uncertain significance Single submitter
- PRCP p.Leu6Phe Uncertain significance Single submitter
- PRCP p.Lys159Arg Uncertain significance Single submitter
- PRCP p.Lys414Glu Uncertain significance Single submitter
- PRCP p.Met106Thr Uncertain significance Single submitter
- PRCP p.Met116Ile Uncertain significance Single submitter
- PRCP p.Met195Val Uncertain significance Single submitter
- PRCP p.Met468Ile Uncertain significance Single submitter
- PRCP p.Met481Ile Uncertain significance Single submitter
- PRCP p.Met481Val Uncertain significance Single submitter
- PRCP p.Phe209Ser Uncertain significance Single submitter
- PRCP p.Pro370Ala Uncertain significance Single submitter
- PRCP p.Ser236Gly Uncertain significance Single submitter
- PRCP p.Ser40Tyr Uncertain significance Single submitter
- PRCP p.Ser418Leu Uncertain significance Single submitter
- PRCP p.Ser85Leu Uncertain significance Single submitter
- PRCP p.Thr224Ile Uncertain significance Single submitter
- PRCP p.Thr351Ala Uncertain significance Single submitter
- PRCP p.Thr356Pro Uncertain significance Single submitter
- PRCP p.Thr365Ile Uncertain significance Single submitter
- PRCP p.Thr409Ala Uncertain significance Single submitter
- PRCP p.Thr64Ile Uncertain significance Single submitter
- PRCP p.Tyr125Cys Uncertain significance Single submitter
- PRCP p.Tyr334His Uncertain significance Single submitter
- PRCP p.Val118Met Uncertain significance Single submitter
- PRCP p.Val217Ile Uncertain significance Single submitter
- PRCP p.Val308Ala Uncertain significance Single submitter
- PRCP p.Val65Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- PRCP p.Arg71Gln Uncertain significance Single submitter
- PRCP p.Asn285Lys Uncertain significance Single submitter
- PRCP p.Ile96Met Uncertain significance Single submitter
- PRCP p.Ser31Cys Uncertain significance Single submitter
- PRCP p.Thr408Pro Uncertain significance Single submitter
- PRCP p.Trp278Arg Uncertain significance Single submitter
- PRCP p.Val222Ile Uncertain significance Single submitter
- PRCP p.Val289Met Uncertain significance Single submitter
- PRCP p.Val448Phe Uncertain significance Single submitter
All PRCP variants
Benign 2
- p.Ala350Glu Single submitter
- p.Ile86Met Single submitter
Likely benign 1
- p.Phe53Ile Single submitter
Uncertain significance 70
- p.Ala201Glu Single submitter ⚠
- p.Ala260Gly Single submitter ⚠
- p.Arg163Lys Single submitter ⚠
- p.Arg227Ser Single submitter ⚠
- p.Arg239Ser Single submitter ⚠
- p.Arg460Cys Single submitter
- p.Arg460His Single submitter
- p.Arg71Gln Single submitter ⚠
- p.Asn285Lys Single submitter ⚠
- p.Asn296Tyr Single submitter ⚠
- p.Asn315Thr Single submitter ⚠
- p.Asn415Asp Single submitter ⚠
- p.Asn82Lys Single submitter ⚠
- p.Asp271Gly Single submitter ⚠
- p.Asp290Gly Single submitter ⚠
- p.Asp377Asn Single submitter ⚠
- p.Cys394Ser Single submitter ⚠
- p.Gln208His Single submitter ⚠
- p.Gln255Arg Single submitter ⚠
- p.Gln55Arg Single submitter ⚠
- p.Glu112Lys Single submitter ⚠
- p.Glu148Gly Single submitter
- p.Gly178Asp Single submitter ⚠
- p.Gly230Ser Single submitter ⚠
- p.Gly413Val Single submitter ⚠
- p.Gly435Asp Single submitter ⚠
- p.His383Arg Single submitter ⚠
- p.His455Arg Single submitter ⚠
- p.His480Arg Single submitter ⚠
- p.His496Arg Single submitter ⚠
- p.Ile422Val Single submitter ⚠
- p.Ile96Met Single submitter ⚠
- p.Leu129Phe Single submitter ⚠
- p.Leu29Arg Single submitter ⚠
- p.Leu331Val Single submitter ⚠
- p.Leu6Phe Single submitter ⚠
- p.Lys159Arg Single submitter ⚠
- p.Lys414Glu Single submitter ⚠
- p.Met106Ile Single submitter
- p.Met106Thr Single submitter ⚠
- p.Met116Ile Single submitter ⚠
- p.Met195Val Single submitter ⚠
- p.Met468Ile Single submitter ⚠
- p.Met481Ile Single submitter ⚠
- p.Met481Val Single submitter ⚠
- p.Phe209Ser Single submitter ⚠
- p.Pro370Ala Single submitter ⚠
- p.Pro370Thr Single submitter
- p.Ser236Gly Single submitter ⚠
- p.Ser31Cys Single submitter ⚠
- p.Ser40Tyr Single submitter ⚠
- p.Ser418Leu Single submitter ⚠
- p.Ser85Leu Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Thr351Ala Single submitter ⚠
- p.Thr356Pro Single submitter ⚠
- p.Thr365Ile Single submitter ⚠
- p.Thr408Pro Single submitter ⚠
- p.Thr409Ala Single submitter ⚠
- p.Thr64Ile Single submitter ⚠
- p.Trp278Arg Single submitter ⚠
- p.Tyr125Cys Single submitter ⚠
- p.Tyr334His Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val217Ile Single submitter ⚠
- p.Val222Ile Single submitter ⚠
- p.Val289Met Single submitter ⚠
- p.Val308Ala Single submitter ⚠
- p.Val448Phe Single submitter ⚠
- p.Val65Leu Single submitter ⚠