PRDM7 — 65 ClinVar variants
All ClinVar germline PRDM7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
3 Likely benign · 62 Uncertain significance
Full PRDM7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRDM7 p.Ala122Val Uncertain significance Single submitter
- PRDM7 p.Ala264Val Uncertain significance Single submitter
- PRDM7 p.Ala322Asp Uncertain significance Single submitter
- PRDM7 p.Arg77Gln Uncertain significance Single submitter
- PRDM7 p.Asn126Tyr Uncertain significance Single submitter
- PRDM7 p.Asn138His Uncertain significance Single submitter
- PRDM7 p.Asn236Asp Uncertain significance Single submitter
- PRDM7 p.Asp283Glu Uncertain significance Single submitter
- PRDM7 p.Asp324Asn Uncertain significance Single submitter
- PRDM7 p.Gln163His Uncertain significance Single submitter
- PRDM7 p.Gln328His Uncertain significance Single submitter
- PRDM7 p.Glu263Lys Uncertain significance Single submitter
- PRDM7 p.Glu375Lys Uncertain significance Single submitter
- PRDM7 p.Glu89Lys Uncertain significance Single submitter
- PRDM7 p.Ile194Met Uncertain significance Single submitter
- PRDM7 p.Ile371Thr Uncertain significance Single submitter
- PRDM7 p.Ile371Val Uncertain significance Single submitter
- PRDM7 p.Lys114Glu Uncertain significance Single submitter
- PRDM7 p.Met180Ile Uncertain significance Single submitter
- PRDM7 p.Phe212Leu Uncertain significance Single submitter
- PRDM7 p.Pro151Leu Uncertain significance Single submitter
- PRDM7 p.Ser10Thr Uncertain significance Single submitter
- PRDM7 p.Ser123Leu Uncertain significance Single submitter
- PRDM7 p.Ser161Thr Uncertain significance Single submitter
- PRDM7 p.Ser390Arg Uncertain significance Single submitter
- PRDM7 p.Ser397Ala Uncertain significance Single submitter
- PRDM7 p.Ser398Asn Uncertain significance Single submitter
- PRDM7 p.Thr136Met Uncertain significance Single submitter
- PRDM7 p.Thr96Ile Uncertain significance Single submitter
- PRDM7 p.Trp408Arg Uncertain significance Single submitter
- PRDM7 p.Trp408Leu Uncertain significance Single submitter
- PRDM7 p.Val225Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- PRDM7 p.Ala313Pro Uncertain significance Single submitter
- PRDM7 p.Ala68Gly Uncertain significance Single submitter
- PRDM7 p.Arg237Cys Uncertain significance Single submitter
- PRDM7 p.Arg323Gln Uncertain significance Single submitter
- PRDM7 p.Arg323Trp Uncertain significance Single submitter
- PRDM7 p.Arg50His Uncertain significance Single submitter
- PRDM7 p.Asn314Thr Uncertain significance Single submitter
- PRDM7 p.Asp199Tyr Uncertain significance Single submitter
- PRDM7 p.Asp201Glu Uncertain significance Single submitter
- PRDM7 p.Asp324His Uncertain significance Single submitter
- PRDM7 p.Cys344Arg Uncertain significance Single submitter
- PRDM7 p.Gln334His Uncertain significance Single submitter
- PRDM7 p.Gln338Glu Uncertain significance Single submitter
- PRDM7 p.Glu303Lys Uncertain significance Single submitter
- PRDM7 p.Gly245Arg Uncertain significance Single submitter
- PRDM7 p.Gly252Asp Uncertain significance Single submitter
- PRDM7 p.Gly358Val Uncertain significance Single submitter
- PRDM7 p.His272Tyr Uncertain significance Single submitter
- PRDM7 p.Ile248Thr Uncertain significance Single submitter
- PRDM7 p.Leu240Val Uncertain significance Single submitter
- PRDM7 p.Leu258Ile Uncertain significance Single submitter
- PRDM7 p.Pro197Leu Likely benign Single submitter
- PRDM7 p.Pro244Leu Uncertain significance Single submitter
- PRDM7 p.Thr281Arg Uncertain significance Single submitter
- PRDM7 p.Trp261Cys Uncertain significance Single submitter
- PRDM7 p.Tyr276Cys Uncertain significance Single submitter
- PRDM7 p.Tyr58Cys Uncertain significance Single submitter
- PRDM7 p.Val54Gly Uncertain significance Single submitter
All PRDM7 variants
Likely benign 3
- p.Asn125Ser Single submitter
- p.Pro197Leu Single submitter ⚠
- p.Tyr181= Single submitter
Uncertain significance 62
- p.Ala122Val Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala313Pro Single submitter ⚠
- p.Ala322Asp Single submitter ⚠
- p.Ala68Gly Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg323Trp Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Asn126Tyr Single submitter ⚠
- p.Asn138His Single submitter ⚠
- p.Asn236Asp Single submitter ⚠
- p.Asn314Thr Single submitter ⚠
- p.Asp199Tyr Single submitter ⚠
- p.Asp201Glu Single submitter ⚠
- p.Asp283Glu Single submitter ⚠
- p.Asp324Asn Single submitter ⚠
- p.Asp324His Single submitter ⚠
- p.Cys344Arg Single submitter ⚠
- p.Gln163His Single submitter ⚠
- p.Gln328His Single submitter ⚠
- p.Gln334His Single submitter ⚠
- p.Gln338Glu Single submitter ⚠
- p.Glu263Lys Single submitter ⚠
- p.Glu303Lys Single submitter ⚠
- p.Glu375Lys Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly245Arg Single submitter ⚠
- p.Gly252Asp Single submitter ⚠
- p.Gly274Ala Single submitter
- p.Gly358Val Single submitter ⚠
- p.His272Tyr Single submitter ⚠
- p.Ile194Met Single submitter ⚠
- p.Ile248Thr Single submitter ⚠
- p.Ile371Thr Single submitter ⚠
- p.Ile371Val Single submitter ⚠
- p.Leu240Val Single submitter ⚠
- p.Leu258Ile Single submitter ⚠
- p.Lys114Glu Single submitter ⚠
- p.Met180Ile Single submitter ⚠
- p.Phe212Leu Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro244Leu Single submitter ⚠
- p.Ser10Thr Single submitter ⚠
- p.Ser123Leu Single submitter ⚠
- p.Ser161Thr Single submitter ⚠
- p.Ser251Pro Single submitter
- p.Ser390Arg Single submitter ⚠
- p.Ser397Ala Single submitter ⚠
- p.Ser398Asn Single submitter ⚠
- p.Thr136Met Single submitter ⚠
- p.Thr281Arg Single submitter ⚠
- p.Thr96Ile Single submitter ⚠
- p.Trp261Cys Single submitter ⚠
- p.Trp356Leu Single submitter
- p.Trp408Arg Single submitter ⚠
- p.Trp408Leu Single submitter ⚠
- p.Tyr276Cys Single submitter ⚠
- p.Tyr58Cys Single submitter ⚠
- p.Val225Ile Single submitter ⚠
- p.Val54Gly Single submitter ⚠