PRDX2 — 12 ClinVar variants
All ClinVar germline PRDX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
12 Uncertain significance
Full PRDX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRDX2 p.Ala24Val Uncertain significance Single submitter
- PRDX2 p.Arg110Cys Uncertain significance Single submitter
- PRDX2 p.Arg110His Uncertain significance Single submitter
- PRDX2 p.Arg91Gln Uncertain significance Single submitter
- PRDX2 p.Asp153Glu Uncertain significance Single submitter
- PRDX2 p.Ile124Thr Uncertain significance Single submitter
- PRDX2 p.Leu129Pro Uncertain significance Single submitter
- PRDX2 p.Tyr193His Uncertain significance Single submitter
- PRDX2 p.Val107Met Uncertain significance Single submitter
- PRDX2 p.Val117Met Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All PRDX2 variants
Uncertain significance 12
- p.Ala24Val Single submitter ⚠
- p.Arg110Cys Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Asn198Tyr Single submitter ⚠
- p.Asp153Glu Single submitter ⚠
- p.Gly116Ser Single submitter
- p.Ile124Thr Single submitter ⚠
- p.Leu129Pro Single submitter ⚠
- p.Tyr193His Single submitter ⚠
- p.Val107Met Single submitter ⚠
- p.Val117Met Single submitter ⚠