PRDX4 — 24 ClinVar variants
All ClinVar germline PRDX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Benign · 23 Uncertain significance
Full PRDX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRDX4 p.Ala9Thr Uncertain significance Single submitter
- PRDX4 p.Asp179His Uncertain significance Single submitter
- PRDX4 p.Asp268Asn Uncertain significance Single submitter
- PRDX4 p.Asp71Tyr Uncertain significance Single submitter
- PRDX4 p.Glu39Gln Uncertain significance Single submitter
- PRDX4 p.Glu42Lys Uncertain significance Single submitter
- PRDX4 p.Glu49Gln Uncertain significance Single submitter
- PRDX4 p.Glu63Asp Uncertain significance Single submitter
-
PRDX4 p.Gly242Arg
Uncertain significance
Single submitter
Neurodevelopmental delay
- PRDX4 p.Gly62Arg Uncertain significance Single submitter
- PRDX4 p.His14Arg Uncertain significance Single submitter
- PRDX4 p.His17Asn Uncertain significance Single submitter
- PRDX4 p.Ile141Val Uncertain significance Single submitter
- PRDX4 p.Leu270Arg Uncertain significance Single submitter
- PRDX4 p.Lys240Arg Uncertain significance Single submitter
- PRDX4 p.Pro12Ser Uncertain significance Single submitter
- PRDX4 p.Thr10Ala Uncertain significance Single submitter
- PRDX4 p.Thr126Ser Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PRDX4 variants
Benign 1
- p.Asp105Asn Multiple submitters ⚠
Uncertain significance 23
- p.Ala9Thr Single submitter ⚠
- p.Arg107Cys Single submitter ⚠
- p.Arg139Thr Single submitter ⚠
- p.Asp179His Single submitter ⚠
- p.Asp268Asn Single submitter ⚠
- p.Asp71Tyr Single submitter ⚠
- p.Glu39Gln Single submitter ⚠
- p.Glu42Lys Single submitter ⚠
- p.Glu49Gln Single submitter ⚠
- p.Glu63Asp Single submitter ⚠
- p.Gly242Arg Single submitter Neurodevelopmental delay ⚠
- p.Gly62Arg Single submitter ⚠
- p.His14Arg Single submitter ⚠
- p.His17Asn Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Leu270Arg Single submitter ⚠
- p.Lys240Arg Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Thr10Ala Single submitter ⚠
- p.Thr126Ser Single submitter ⚠
- p.Thr181Ile Single submitter ⚠
- p.Thr91Arg Single submitter
- p.Val59Leu Single submitter ⚠