PRDX5 — 21 ClinVar variants
All ClinVar germline PRDX5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
3 Likely benign · 18 Uncertain significance
Full PRDX5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRDX5 p.Ala192Thr Uncertain significance Single submitter
- PRDX5 p.Ala27Val Uncertain significance Single submitter
- PRDX5 p.Ala30Thr Uncertain significance Single submitter
- PRDX5 p.Arg176Gln Uncertain significance Single submitter
- PRDX5 p.Asn129Ile Uncertain significance Single submitter
- PRDX5 p.Gly107Glu Uncertain significance Single submitter
- PRDX5 p.Gly23Arg Uncertain significance Single submitter
- PRDX5 p.Leu17Ile Uncertain significance Single submitter
- PRDX5 p.Phe157Val Uncertain significance Single submitter
- PRDX5 p.Ser205Gly Uncertain significance Single submitter
- PRDX5 p.Ser25Phe Uncertain significance Single submitter
- PRDX5 p.Ser25Pro Uncertain significance Single submitter
- PRDX5 p.Thr103Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PRDX5 variants
Likely benign 3
- p.Gly19Arg Single submitter
- p.Ser47Arg Single submitter
- p.Val6Leu Single submitter
Uncertain significance 18
- p.Ala192Thr Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Arg176Gln Single submitter ⚠
- p.Asn129Ile Single submitter ⚠
- p.Gly107Glu Single submitter ⚠
- p.Gly23Arg Single submitter ⚠
- p.His104Gln Single submitter ⚠
- p.Leu17Ile Single submitter ⚠
- p.Lys86Glu Single submitter ⚠
- p.Met183Ile Single submitter ⚠
- p.Phe157Val Single submitter ⚠
- p.Phe46Leu Single submitter ⚠
- p.Ser205Gly Single submitter ⚠
- p.Ser25Phe Single submitter ⚠
- p.Ser25Pro Single submitter ⚠
- p.Thr103Ala Single submitter ⚠
- p.Val92Leu Single submitter ⚠