PRKACG — 84 ClinVar variants
All ClinVar germline PRKACG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
3 Benign · 3 Benign/Likely benign · 16 Likely benign · 62 Uncertain significance
Full PRKACG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRKACG p.Ala6Asp Uncertain significance Multiple submitters
- PRKACG p.Lys296Arg Uncertain significance Multiple submitters
- PRKACG p.Ala21Asp Uncertain significance Single submitter
- PRKACG p.Ala241Thr Uncertain significance Single submitter
- PRKACG p.Ala35Thr Uncertain significance Single submitter
- PRKACG p.Ala39Thr Uncertain significance Single submitter
- PRKACG p.Ala6Pro Uncertain significance Single submitter
- PRKACG p.Arg132Leu Uncertain significance Single submitter
- PRKACG p.Arg257Gln Uncertain significance Single submitter
- PRKACG p.Asn114Ser Uncertain significance Single submitter
- PRKACG p.Asn17Ser Uncertain significance Single submitter
- PRKACG p.Asp26Glu Uncertain significance Single submitter
- PRKACG p.Gln182Lys Uncertain significance Single submitter
- PRKACG p.Gly323Glu Uncertain significance Single submitter
- PRKACG p.Gly67Ser Uncertain significance Single submitter
- PRKACG p.Leu117Pro Uncertain significance Single submitter
- PRKACG p.Leu266Phe Uncertain significance Single submitter
- PRKACG p.Leu90Pro Uncertain significance Single submitter
- PRKACG p.Lys309Arg Uncertain significance Single submitter
- PRKACG p.Met129Leu Uncertain significance Single submitter
- PRKACG p.Phe236Ile Uncertain significance Single submitter
- PRKACG p.Phe298Leu Uncertain significance Single submitter
- PRKACG p.Val136Leu Uncertain significance Single submitter
- PRKACG p.Val61Ala Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- PRKACG p.Asp324Gly Uncertain significance Multiple submitters
- PRKACG p.Gln150Arg Uncertain significance Multiple submitters
- PRKACG p.Gly254Arg Uncertain significance Multiple submitters
- PRKACG p.Val80Ala Uncertain significance Multiple submitters
- PRKACG p.Ala154Asp Uncertain significance Single submitter
- PRKACG p.Ala207Val Uncertain significance Single submitter
- PRKACG p.Ala98Thr Uncertain significance Single submitter
- PRKACG p.Arg138Ser Uncertain significance Single submitter
- PRKACG p.Arg166His Uncertain significance Single submitter
- PRKACG p.Arg257Trp Uncertain significance Single submitter
- PRKACG p.Arg271Leu Uncertain significance Single submitter
- PRKACG p.Arg62Ser Uncertain significance Single submitter
- PRKACG p.Asn287Lys Uncertain significance Single submitter
- PRKACG p.Asn327Ser Uncertain significance Single submitter
- PRKACG p.Asp291Asn Uncertain significance Single submitter
- PRKACG p.Asp42Val Uncertain significance Single submitter
- PRKACG p.Gln150Leu Uncertain significance Single submitter
- PRKACG p.Glu204Gln Uncertain significance Single submitter
- PRKACG p.Glu204Gly Uncertain significance Single submitter
- PRKACG p.Glu231Lys Uncertain significance Single submitter
- PRKACG p.Glu92Lys Uncertain significance Single submitter
- PRKACG p.Gly179Ser Uncertain significance Single submitter
- PRKACG p.Gly215Arg Uncertain significance Single submitter
- PRKACG p.Ile164Thr Uncertain significance Single submitter
- PRKACG p.Leu285Phe Uncertain significance Single submitter
- PRKACG p.Leu50Gln Uncertain significance Single submitter
- PRKACG p.Lys193Glu Uncertain significance Single submitter
- PRKACG p.Met129Thr Uncertain significance Single submitter
- PRKACG p.Pro102Ser Uncertain significance Single submitter
- PRKACG p.Pro238Arg Uncertain significance Single submitter
- PRKACG p.Pro317Arg Uncertain significance Single submitter
- PRKACG p.Pro317Ser Uncertain significance Single submitter
- PRKACG p.Thr196Ser Uncertain significance Single submitter
- PRKACG p.Thr49Met Uncertain significance Single submitter
- PRKACG p.Tyr123Cys Uncertain significance Single submitter
- PRKACG p.Val234Leu Uncertain significance Single submitter
All PRKACG variants
Benign 3
- c.*197C>G Multiple submitters
- c.*198_*199insGC Single submitter
- p.Ile99= Single submitter
Benign/Likely benign 3
- p.Ala241= Multiple submitters
- p.His268Asp Multiple submitters
- p.Lys310= Multiple submitters
Likely benign 16
- p.Tyr230= Multiple submitters
- p.Arg286= Single submitter
- p.Arg30= Single submitter
- p.Asn37= Single submitter
- p.His143= Single submitter
- p.Leu133= Single submitter
- p.Leu270= Single submitter
- p.Phe186= Single submitter
- p.Phe236= Single submitter
- p.Ser140= Single submitter
- p.Ser160= Single submitter
- p.Ser253= Single submitter
- p.Thr10= Single submitter
- p.Tyr331= Single submitter
- c.-10C>G No assertion criteria PRKACG-related disorder
- p.Val80= No assertion criteria PRKACG-related disorder
Uncertain significance 62
- p.Ala6Asp Multiple submitters ⚠
- p.Asp324Gly Multiple submitters ⚠
- p.Gln150Arg Multiple submitters ⚠
- p.Gly254Arg Multiple submitters ⚠
- p.Lys296Arg Multiple submitters ⚠
- p.Val80Ala Multiple submitters ⚠
- p.Ala154Asp Single submitter ⚠
- p.Ala207Val Single submitter ⚠
- p.Ala21Asp Single submitter ⚠
- p.Ala241Thr Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala6Pro Single submitter ⚠
- p.Ala98Thr Single submitter ⚠
- p.Arg132Leu Single submitter ⚠
- p.Arg138Ser Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg255fs Single submitter
- p.Arg257Gln Single submitter ⚠
- p.Arg257Trp Single submitter ⚠
- p.Arg271Leu Single submitter ⚠
- p.Arg62Ser Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn17Ser Single submitter ⚠
- p.Asn287Lys Single submitter ⚠
- p.Asn327Ser Single submitter ⚠
- p.Asp26Glu Single submitter ⚠
- p.Asp291Asn Single submitter ⚠
- p.Asp42Val Single submitter ⚠
- p.Gln150Leu Single submitter ⚠
- p.Gln182Lys Single submitter ⚠
- p.Glu204Gln Single submitter ⚠
- p.Glu204Gly Single submitter ⚠
- p.Glu231Lys Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly179Ser Single submitter ⚠
- p.Gly215Arg Single submitter ⚠
- p.Gly323Glu Single submitter ⚠
- p.Gly67Ser Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Leu117Pro Single submitter ⚠
- p.Leu266Phe Single submitter ⚠
- p.Leu285Phe Single submitter ⚠
- p.Leu50Gln Single submitter ⚠
- p.Leu90Pro Single submitter ⚠
- p.Lys193Glu Single submitter ⚠
- p.Lys309Arg Single submitter ⚠
- p.Met129Leu Single submitter ⚠
- p.Met129Thr Single submitter ⚠
- p.Phe236Ile Single submitter ⚠
- p.Phe298Leu Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro238Arg Single submitter ⚠
- p.Pro317Arg Single submitter ⚠
- p.Pro317Ser Single submitter ⚠
- p.Thr196Ser Single submitter ⚠
- p.Thr49Met Single submitter ⚠
- p.Tyr123Cys Single submitter ⚠
- p.Tyr240Ter Single submitter
- p.Val136Leu Single submitter ⚠
- p.Val234Leu Single submitter ⚠
- p.Val61Ala Single submitter ⚠