PRKAR2A — 55 ClinVar variants
All ClinVar germline PRKAR2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
3 Likely benign · 52 Uncertain significance
Full PRKAR2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRKAR2A p.Ala45Val Uncertain significance Single submitter
- PRKAR2A p.Ala47Val Uncertain significance Single submitter
- PRKAR2A p.Ala52Val Uncertain significance Single submitter
- PRKAR2A p.Ala74Ser Uncertain significance Single submitter
- PRKAR2A p.Arg158Lys Uncertain significance Single submitter
- PRKAR2A p.Arg195Cys Uncertain significance Single submitter
- PRKAR2A p.Arg313Gly Uncertain significance Single submitter
- PRKAR2A p.Asn142Ser Uncertain significance Single submitter
- PRKAR2A p.Asn192Asp Uncertain significance Single submitter
- PRKAR2A p.Asp108Asn Uncertain significance Single submitter
- PRKAR2A p.Asp115Gly Uncertain significance Single submitter
- PRKAR2A p.Asp69Ala Uncertain significance Single submitter
- PRKAR2A p.Asp83Glu Uncertain significance Single submitter
- PRKAR2A p.Gln15His Uncertain significance Single submitter
- PRKAR2A p.Gln24Glu Uncertain significance Single submitter
- PRKAR2A p.Gly198Ser Uncertain significance Single submitter
- PRKAR2A p.Gly333Arg Uncertain significance Single submitter
- PRKAR2A p.Gly403Arg Uncertain significance Single submitter
- PRKAR2A p.His3Tyr Uncertain significance Single submitter
- PRKAR2A p.Ile241Val Uncertain significance Single submitter
- PRKAR2A p.Ile273Thr Uncertain significance Single submitter
- PRKAR2A p.Ile281Phe Uncertain significance Single submitter
- PRKAR2A p.Leu370Phe Uncertain significance Single submitter
- PRKAR2A p.Lys263Thr Uncertain significance Single submitter
- PRKAR2A p.Lys294Arg Uncertain significance Single submitter
- PRKAR2A p.Met392Ile Uncertain significance Single submitter
- PRKAR2A p.Met392Thr Uncertain significance Single submitter
- PRKAR2A p.Phe37Leu Uncertain significance Single submitter
- PRKAR2A p.Pro107Ser Uncertain significance Single submitter
- PRKAR2A p.Pro27His Uncertain significance Single submitter
- PRKAR2A p.Pro51Leu Uncertain significance Single submitter
- PRKAR2A p.Pro66Leu Uncertain significance Single submitter
- PRKAR2A p.Pro68Leu Uncertain significance Single submitter
- PRKAR2A p.Ser316Pro Uncertain significance Single submitter
- PRKAR2A p.Ser396Arg Uncertain significance Single submitter
- PRKAR2A p.Ser396Asn Uncertain significance Single submitter
- PRKAR2A p.Ser78Gly Uncertain significance Single submitter
- PRKAR2A p.Ser92Gly Uncertain significance Single submitter
- PRKAR2A p.Thr114Arg Uncertain significance Single submitter
- PRKAR2A p.Tyr200Cys Uncertain significance Single submitter
- PRKAR2A p.Val30Ile Uncertain significance Single submitter
- PRKAR2A p.Val325Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PRKAR2A p.Arg203Cys Uncertain significance Single submitter
- PRKAR2A p.Asp284Gly Uncertain significance Single submitter
- PRKAR2A p.Glu305Lys Uncertain significance Single submitter
- PRKAR2A p.Gly394Ser Uncertain significance Single submitter
- PRKAR2A p.His165Tyr Uncertain significance Single submitter
- PRKAR2A p.Leu10Phe Uncertain significance Single submitter
- PRKAR2A p.Ser149Cys Uncertain significance Single submitter
All PRKAR2A variants
Likely benign 3
- p.Arg203His Single submitter
- p.Leu59Pro Single submitter
- p.Thr54Pro Single submitter
Uncertain significance 52
- p.Ala45Val Single submitter ⚠
- p.Ala47Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala74Ser Single submitter ⚠
- p.Arg158Lys Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg195Gly Single submitter
- p.Arg203Cys Single submitter ⚠
- p.Arg313Gly Single submitter ⚠
- p.Asn142Ser Single submitter ⚠
- p.Asn192Asp Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp115Gly Single submitter ⚠
- p.Asp191His Single submitter
- p.Asp284Gly Single submitter ⚠
- p.Asp69Ala Single submitter ⚠
- p.Asp83Glu Single submitter ⚠
- p.Gln15His Single submitter ⚠
- p.Gln24Glu Single submitter ⚠
- p.Glu305Lys Single submitter ⚠
- p.Gly198Ser Single submitter ⚠
- p.Gly333Arg Single submitter ⚠
- p.Gly394Ser Single submitter ⚠
- p.Gly403Arg Single submitter ⚠
- p.His165Tyr Single submitter ⚠
- p.His3Tyr Single submitter ⚠
- p.Ile241Val Single submitter ⚠
- p.Ile273Thr Single submitter ⚠
- p.Ile281Phe Single submitter ⚠
- p.Leu10Phe Single submitter ⚠
- p.Leu370Phe Single submitter ⚠
- p.Lys263Thr Single submitter ⚠
- p.Lys294Arg Single submitter ⚠
- p.Met392Ile Single submitter ⚠
- p.Met392Thr Single submitter ⚠
- p.Phe37Leu Single submitter ⚠
- p.Pro107Ser Single submitter ⚠
- p.Pro121Arg Single submitter
- p.Pro27His Single submitter ⚠
- p.Pro51Leu Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Pro68Leu Single submitter ⚠
- p.Ser149Cys Single submitter ⚠
- p.Ser316Pro Single submitter ⚠
- p.Ser396Arg Single submitter ⚠
- p.Ser396Asn Single submitter ⚠
- p.Ser78Gly Single submitter ⚠
- p.Ser92Gly Single submitter ⚠
- p.Thr114Arg Single submitter ⚠
- p.Tyr200Cys Single submitter ⚠
- p.Val30Ile Single submitter ⚠
- p.Val325Ala Single submitter ⚠