PRKAR2B — 32 ClinVar variants
All ClinVar germline PRKAR2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
3 Benign · 1 Likely benign · 28 Uncertain significance
Full PRKAR2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRKAR2B p.Arg218His Uncertain significance Single submitter
- PRKAR2B p.Asn143Tyr Uncertain significance Single submitter
- PRKAR2B p.Asn229Asp Uncertain significance Single submitter
- PRKAR2B p.Asn75Ser Uncertain significance Single submitter
- PRKAR2B p.Cys373Tyr Uncertain significance Single submitter
- PRKAR2B p.Glu284Gln Uncertain significance Single submitter
- PRKAR2B p.Glu78Lys Uncertain significance Single submitter
- PRKAR2B p.Glu92Ala Uncertain significance Single submitter
- PRKAR2B p.Gly66Arg Uncertain significance Single submitter
- PRKAR2B p.His366Arg Uncertain significance Single submitter
- PRKAR2B p.Leu153Pro Uncertain significance Single submitter
- PRKAR2B p.Lys150Arg Uncertain significance Single submitter
- PRKAR2B p.Met411Val Uncertain significance Single submitter
- PRKAR2B p.Pro160Leu Uncertain significance Single submitter
- PRKAR2B p.Pro70Ser Uncertain significance Single submitter
- PRKAR2B p.Pro80Ser Uncertain significance Single submitter
- PRKAR2B p.Ser220Asn Uncertain significance Single submitter
- PRKAR2B p.Ser345Leu Uncertain significance Single submitter
- PRKAR2B p.Thr294Ser Uncertain significance Single submitter
- PRKAR2B p.Tyr228Cys Uncertain significance Single submitter
- PRKAR2B p.Val296Leu Uncertain significance Single submitter
- PRKAR2B p.Val333Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All PRKAR2B variants
Benign 3
- c.343+5G>A Multiple submitters
- p.Ile396= Multiple submitters
- p.Val296= Single submitter
Likely benign 1
- p.Ser309Leu Single submitter
Uncertain significance 28
- c.307+1G>A Single submitter
- p.Arg218His Single submitter ⚠
- p.Asn143Tyr Single submitter ⚠
- p.Asn229Asp Single submitter ⚠
- p.Asn229Ser Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Asp140His Single submitter ⚠
- p.Cys344Tyr Single submitter
- p.Cys373Tyr Single submitter ⚠
- p.Glu281Val Single submitter
- p.Glu284Gln Single submitter ⚠
- p.Glu78Lys Single submitter ⚠
- p.Glu92Ala Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.His366Arg Single submitter ⚠
- p.Leu153Pro Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Met411Val Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Pro80Ser Single submitter ⚠
- p.Ser220Asn Single submitter ⚠
- p.Ser345Leu Single submitter ⚠
- p.Thr294Ser Single submitter ⚠
- p.Tyr228Cys Single submitter ⚠
- p.Val291Ala Single submitter ⚠
- p.Val296Leu Single submitter ⚠
- p.Val333Ala Single submitter ⚠