PRKCA — 53 ClinVar variants
All ClinVar germline PRKCA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
8 Benign · 11 Likely benign · 34 Uncertain significance
Full PRKCA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRKCA p.Ala356Thr Uncertain significance Single submitter
- PRKCA p.Arg324Lys Uncertain significance Single submitter
- PRKCA p.Arg333Gln Uncertain significance Single submitter
- PRKCA p.Arg496Gly Uncertain significance Single submitter
- PRKCA p.Asn554Ser Uncertain significance Single submitter
- PRKCA p.Asp203Gly Uncertain significance Single submitter
- PRKCA p.Asp36Asn Uncertain significance Single submitter
- PRKCA p.Asp36Glu Uncertain significance Single submitter
- PRKCA p.Asp36Gly Uncertain significance Single submitter
- PRKCA p.Gln68His Uncertain significance Single submitter
- PRKCA p.Glu225Ala Uncertain significance Single submitter
- PRKCA p.Gly314Asp Uncertain significance Single submitter
- PRKCA p.His488Arg Uncertain significance Single submitter
- PRKCA p.Lys388Gln Uncertain significance Single submitter
- PRKCA p.Lys45Arg Uncertain significance Single submitter
- PRKCA p.Lys563Arg Uncertain significance Single submitter
- PRKCA p.Met186Leu Uncertain significance Single submitter
- PRKCA p.Met186Val Uncertain significance Single submitter
- PRKCA p.Met267Leu Uncertain significance Single submitter
- PRKCA p.Pro221Leu Uncertain significance Single submitter
- PRKCA p.Pro612Ser Uncertain significance Single submitter
- PRKCA p.Ser272Thr Uncertain significance Single submitter
- PRKCA p.Thr401Met Uncertain significance Single submitter
- PRKCA p.Tyr275His Uncertain significance Single submitter
- PRKCA p.Val242Leu Uncertain significance Single submitter
- PRKCA p.Val288Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
- PRKCA p.Asn468Asp Uncertain significance Single submitter
- PRKCA p.Leu278Phe Uncertain significance Single submitter
- PRKCA p.Met130Val Uncertain significance Single submitter
- PRKCA p.Val526Ile Uncertain significance Single submitter
-
PRKCA p.Asp96Glu
Uncertain significance
No assertion criteria
PRKCA-related disorder
All PRKCA variants
Benign 8
Likely benign 11
- c.1606-8C>T Single submitter
- p.Asn421= Single submitter
- p.Asn468= Single submitter
- p.Gln326= Single submitter
- p.Met489Val Single submitter
- p.Pro221= Single submitter
- p.Pro635= Single submitter
- p.Tyr557= Single submitter
- p.Val636Ile Single submitter
- c.-4dup No assertion criteria PRKCA-related disorder
- p.Pro93= No assertion criteria PRKCA-related disorder
Uncertain significance 34
- p.Ala356Thr Single submitter ⚠
- p.Arg324Lys Single submitter ⚠
- p.Arg333Gln Single submitter ⚠
- p.Arg496Gly Single submitter ⚠
- p.Asn468Asp Single submitter ⚠
- p.Asn554Ser Single submitter ⚠
- p.Asp203Gly Single submitter ⚠
- p.Asp36Asn Single submitter ⚠
- p.Asp36Glu Single submitter ⚠
- p.Asp36Gly Single submitter ⚠
- p.Gln68His Single submitter ⚠
- p.Glu225Ala Single submitter ⚠
- p.Gly314Asp Single submitter ⚠
- p.Gly458Ala Single submitter
- p.His488Arg Single submitter ⚠
- p.Leu278Phe Single submitter ⚠
- p.Lys388Gln Single submitter ⚠
- p.Lys45Arg Single submitter ⚠
- p.Lys563Arg Single submitter ⚠
- p.Met130Val Single submitter ⚠
- p.Met186Leu Single submitter ⚠
- p.Met186Val Single submitter ⚠
- p.Met267Leu Single submitter ⚠
- p.Pro221Leu Single submitter ⚠
- p.Pro612Ser Single submitter ⚠
- p.Ser272Thr Single submitter ⚠
- p.Thr401Met Single submitter ⚠
- p.Tyr275His Single submitter ⚠
- p.Val242Leu Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val526Ile Single submitter ⚠
- p.Val591Met Single submitter
- p.Asp96Glu No assertion criteria PRKCA-related disorder ⚠
- p.Gly257fs No assertion criteria PRKCA-related disorder