PRKCQ — 79 ClinVar variants
All ClinVar germline PRKCQ variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
1 Conflicting · 3 Benign · 2 Likely benign · 73 Uncertain significance
Full PRKCQ gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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PRKCQ p.Pro330Leu
Conflicting
Single submitter
inflammatory bowel disease 1
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRKCQ p.Ala152Thr Uncertain significance Single submitter
- PRKCQ p.Ala407Thr Uncertain significance Single submitter
- PRKCQ p.Ala521Thr Uncertain significance Single submitter
- PRKCQ p.Ala521Val Uncertain significance Single submitter
- PRKCQ p.Arg225Lys Uncertain significance Single submitter
- PRKCQ p.Arg592Gly Uncertain significance Single submitter
- PRKCQ p.Arg600Gln Uncertain significance Single submitter
- PRKCQ p.Arg600Pro Uncertain significance Single submitter
- PRKCQ p.Arg635Gln Uncertain significance Single submitter
- PRKCQ p.Arg674Gln Uncertain significance Single submitter
- PRKCQ p.Arg6Leu Uncertain significance Single submitter
- PRKCQ p.Asn118His Uncertain significance Single submitter
- PRKCQ p.Asn453His Uncertain significance Single submitter
- PRKCQ p.Asn595Ser Uncertain significance Single submitter
- PRKCQ p.Asp533Glu Uncertain significance Single submitter
- PRKCQ p.Gln342Pro Uncertain significance Single submitter
- PRKCQ p.Glu133Asp Uncertain significance Single submitter
- PRKCQ p.Glu133Lys Uncertain significance Single submitter
- PRKCQ p.Glu137Asp Uncertain significance Single submitter
- PRKCQ p.Glu641Ala Uncertain significance Single submitter
- PRKCQ p.Gly22Asp Uncertain significance Single submitter
- PRKCQ p.Gly67Glu Uncertain significance Single submitter
- PRKCQ p.His358Arg Uncertain significance Single submitter
- PRKCQ p.His358Gln Uncertain significance Single submitter
- PRKCQ p.His63Arg Uncertain significance Single submitter
- PRKCQ p.Ile324Val Uncertain significance Single submitter
- PRKCQ p.Ile344Val Uncertain significance Single submitter
- PRKCQ p.Ile408Val Uncertain significance Single submitter
- PRKCQ p.Ile520Phe Uncertain significance Single submitter
- PRKCQ p.Leu551Val Uncertain significance Single submitter
- PRKCQ p.Lys355Glu Uncertain significance Single submitter
- PRKCQ p.Met131Ile Uncertain significance Single submitter
- PRKCQ p.Met44Val Uncertain significance Single submitter
- PRKCQ p.Met458Leu Uncertain significance Single submitter
- PRKCQ p.Pro315Ala Uncertain significance Single submitter
- PRKCQ p.Pro321Thr Uncertain significance Single submitter
- PRKCQ p.Pro334Arg Uncertain significance Single submitter
- PRKCQ p.Pro336Leu Uncertain significance Single submitter
- PRKCQ p.Pro349Ser Uncertain significance Single submitter
- PRKCQ p.Pro362Leu Uncertain significance Single submitter
- PRKCQ p.Pro3Leu Uncertain significance Single submitter
- PRKCQ p.Pro55Ser Uncertain significance Single submitter
- PRKCQ p.Pro649Ser Uncertain significance Single submitter
- PRKCQ p.Pro650Leu Uncertain significance Single submitter
- PRKCQ p.Pro653Leu Uncertain significance Single submitter
- PRKCQ p.Ser126Arg Uncertain significance Single submitter
- PRKCQ p.Ser297Asn Uncertain significance Single submitter
- PRKCQ p.Thr136Met Uncertain significance Single submitter
- PRKCQ p.Thr307Ala Uncertain significance Single submitter
- PRKCQ p.Val157Ile Uncertain significance Single submitter
- PRKCQ p.Val25Ile Uncertain significance Single submitter
- PRKCQ p.Val33Ile Uncertain significance Single submitter
- PRKCQ p.Val611Leu Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- PRKCQ p.Ser479Cys Benign Multiple submitters
- PRKCQ p.Ala410Ser Uncertain significance Single submitter
- PRKCQ p.Ala62Thr Uncertain significance Single submitter
- PRKCQ p.Arg114Gln Uncertain significance Single submitter
- PRKCQ p.Arg674Trp Uncertain significance Single submitter
- PRKCQ p.Asp379Asn Uncertain significance Single submitter
- PRKCQ p.Glu423Asp Uncertain significance Single submitter
- PRKCQ p.Glu84Ala Uncertain significance Single submitter
- PRKCQ p.Gly42Glu Uncertain significance Single submitter
- PRKCQ p.His443Arg Uncertain significance Single submitter
- PRKCQ p.His443Tyr Uncertain significance Single submitter
- PRKCQ p.Ile637Thr Uncertain significance Single submitter
- PRKCQ p.Leu320Phe Uncertain significance Single submitter
- PRKCQ p.Leu569Phe Uncertain significance Single submitter
- PRKCQ p.Leu609Phe Uncertain significance Single submitter
- PRKCQ p.Lys388Arg Uncertain significance Single submitter
- PRKCQ p.Met385Ile Uncertain significance Single submitter
- PRKCQ p.Met701Ile Uncertain significance Single submitter
- PRKCQ p.Ser16Phe Uncertain significance Single submitter
- PRKCQ p.Val501Leu Uncertain significance Single submitter
- PRKCQ p.Val624Met Uncertain significance Single submitter
All PRKCQ variants
Conflicting classifications of pathogenicity 1
- p.Pro330Leu Single submitter inflammatory bowel disease 1 ⚠
Benign 3
- p.Ile214Val Multiple submitters
- p.Ser479Cys Multiple submitters ⚠
- p.Thr442= Multiple submitters
Likely benign 2
- p.Ala24= Single submitter
- p.Met697Ile Single submitter
Uncertain significance 73
- p.Ala152Thr Single submitter ⚠
- p.Ala407Thr Single submitter ⚠
- p.Ala410Ser Single submitter ⚠
- p.Ala521Thr Single submitter ⚠
- p.Ala521Val Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Arg114Gln Single submitter ⚠
- p.Arg225Lys Single submitter ⚠
- p.Arg592Gly Single submitter ⚠
- p.Arg600Gln Single submitter ⚠
- p.Arg600Pro Single submitter ⚠
- p.Arg635Gln Single submitter ⚠
- p.Arg674Gln Single submitter ⚠
- p.Arg674Trp Single submitter ⚠
- p.Arg6Leu Single submitter ⚠
- p.Asn118His Single submitter ⚠
- p.Asn453His Single submitter ⚠
- p.Asn595Ser Single submitter ⚠
- p.Asp379Asn Single submitter ⚠
- p.Asp533Glu Single submitter ⚠
- p.Gln342Pro Single submitter ⚠
- p.Glu133Asp Single submitter ⚠
- p.Glu133Lys Single submitter ⚠
- p.Glu137Asp Single submitter ⚠
- p.Glu423Asp Single submitter ⚠
- p.Glu641Ala Single submitter ⚠
- p.Glu84Ala Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly42Glu Single submitter ⚠
- p.Gly67Glu Single submitter ⚠
- p.His358Arg Single submitter ⚠
- p.His358Gln Single submitter ⚠
- p.His443Arg Single submitter ⚠
- p.His443Tyr Single submitter ⚠
- p.His63Arg Single submitter ⚠
- p.Ile324Val Single submitter ⚠
- p.Ile344Val Single submitter ⚠
- p.Ile408Val Single submitter ⚠
- p.Ile520Phe Single submitter ⚠
- p.Ile637Thr Single submitter ⚠
- p.Leu320Phe Single submitter ⚠
- p.Leu551Val Single submitter ⚠
- p.Leu569Phe Single submitter ⚠
- p.Leu609Phe Single submitter ⚠
- p.Lys355Glu Single submitter ⚠
- p.Lys388Arg Single submitter ⚠
- p.Met131Ile Single submitter ⚠
- p.Met385Ile Single submitter ⚠
- p.Met44Val Single submitter ⚠
- p.Met458Leu Single submitter ⚠
- p.Met701Ile Single submitter ⚠
- p.Pro315Ala Single submitter ⚠
- p.Pro321Thr Single submitter ⚠
- p.Pro334Arg Single submitter ⚠
- p.Pro336Leu Single submitter ⚠
- p.Pro349Ser Single submitter ⚠
- p.Pro362Leu Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Pro649Ser Single submitter ⚠
- p.Pro650Leu Single submitter ⚠
- p.Pro653Leu Single submitter ⚠
- p.Ser126Arg Single submitter ⚠
- p.Ser16Phe Single submitter ⚠
- p.Ser297Asn Single submitter ⚠
- p.Thr136Met Single submitter ⚠
- p.Thr307Ala Single submitter ⚠
- p.Val157Ile Single submitter ⚠
- p.Val25Ile Single submitter ⚠
- p.Val33Ile Single submitter ⚠
- p.Val501Leu Single submitter ⚠
- p.Val611Leu Single submitter ⚠
- p.Val624Met Single submitter ⚠