PRKX — 34 ClinVar variants
All ClinVar germline PRKX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
3 Benign · 6 Likely benign · 25 Uncertain significance
Full PRKX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRKX p.Ala258Gly Uncertain significance Single submitter
- PRKX p.Ala345Val Uncertain significance Single submitter
- PRKX p.Ala76Thr Uncertain significance Single submitter
- PRKX p.Arg139His Uncertain significance Single submitter
- PRKX p.Arg141Trp Uncertain significance Single submitter
- PRKX p.Arg223Lys Uncertain significance Single submitter
- PRKX p.Arg301Gln Uncertain significance Single submitter
- PRKX p.Arg62Trp Uncertain significance Single submitter
- PRKX p.Glu103Lys Uncertain significance Single submitter
- PRKX p.Glu119Lys Uncertain significance Single submitter
- PRKX p.Gly132Ser Uncertain significance Single submitter
- PRKX p.Ile320Met Uncertain significance Single submitter
- PRKX p.Lys323Asn Uncertain significance Single submitter
- PRKX p.Pro312Leu Uncertain significance Single submitter
- PRKX p.Ser305Thr Uncertain significance Single submitter
- PRKX p.Thr189Ala Uncertain significance Single submitter
- PRKX p.Val169Ile Uncertain significance Single submitter
- PRKX p.Val306Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- PRKX p.Arg120Cys Uncertain significance Single submitter
- PRKX p.Arg143Cys Uncertain significance Single submitter
- PRKX p.Arg304Cys Uncertain significance Single submitter
- PRKX p.Pro348Leu Uncertain significance Single submitter
- PRKX p.Ser145Cys Uncertain significance Single submitter
- PRKX p.Val321Met Uncertain significance Single submitter
All PRKX variants
Benign 3
- c.951+10A>T Multiple submitters
- c.952-9G>A Multiple submitters
- p.Asp327= Multiple submitters
Likely benign 6
- p.Arg304His Single submitter
- p.Asp342Asn Single submitter
- p.Gly240= Single submitter
- p.Pro130= Single submitter
- p.Ser14Arg Single submitter
- p.Thr115= Single submitter
Uncertain significance 25
- p.Ala258Gly Single submitter ⚠
- p.Ala345Val Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Arg120Cys Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg141Trp Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg223Lys Single submitter ⚠
- p.Arg301Gln Single submitter ⚠
- p.Arg301Trp Single submitter
- p.Arg304Cys Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Glu103Lys Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Gly132Ser Single submitter ⚠
- p.Ile320Met Single submitter ⚠
- p.Lys323Asn Single submitter ⚠
- p.Pro312Leu Single submitter ⚠
- p.Pro348Leu Single submitter ⚠
- p.Ser145Cys Single submitter ⚠
- p.Ser305Thr Single submitter ⚠
- p.Thr189Ala Single submitter ⚠
- p.Val169Ile Single submitter ⚠
- p.Val306Met Single submitter ⚠
- p.Val321Met Single submitter ⚠