PRLHR — 63 ClinVar variants
All ClinVar germline PRLHR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
1 Benign · 1 Likely benign · 61 Uncertain significance
Full PRLHR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRLHR p.Ala26Thr Uncertain significance Single submitter
- PRLHR p.Ala26Val Uncertain significance Single submitter
- PRLHR p.Ala2Val Uncertain significance Single submitter
- PRLHR p.Ala358Thr Uncertain significance Single submitter
- PRLHR p.Ala44Ser Uncertain significance Single submitter
- PRLHR p.Arg222Ser Uncertain significance Single submitter
- PRLHR p.Arg247Leu Uncertain significance Single submitter
- PRLHR p.Arg270Gly Uncertain significance Single submitter
- PRLHR p.Arg272Trp Uncertain significance Single submitter
- PRLHR p.Arg355Cys Uncertain significance Single submitter
- PRLHR p.Arg355Leu Uncertain significance Single submitter
- PRLHR p.Arg89His Uncertain significance Single submitter
- PRLHR p.Asp207Glu Uncertain significance Single submitter
- PRLHR p.Cys113Tyr Uncertain significance Single submitter
- PRLHR p.Cys134Tyr Uncertain significance Single submitter
- PRLHR p.Cys260Tyr Uncertain significance Single submitter
- PRLHR p.Gln51Arg Uncertain significance Single submitter
- PRLHR p.Glu123Gln Uncertain significance Single submitter
- PRLHR p.His206Gln Uncertain significance Single submitter
- PRLHR p.His295Leu Uncertain significance Single submitter
- PRLHR p.His360Arg Uncertain significance Single submitter
- PRLHR p.His360Tyr Uncertain significance Single submitter
- PRLHR p.His57Arg Uncertain significance Single submitter
- PRLHR p.Ile357Arg Uncertain significance Single submitter
- PRLHR p.Leu14Ile Uncertain significance Single submitter
- PRLHR p.Leu210Pro Uncertain significance Single submitter
- PRLHR p.Leu236Phe Uncertain significance Single submitter
- PRLHR p.Leu323Ile Uncertain significance Single submitter
- PRLHR p.Met109Leu Uncertain significance Single submitter
- PRLHR p.Met325Val Uncertain significance Single submitter
- PRLHR p.Met364Val Uncertain significance Single submitter
- PRLHR p.Pro124Ser Uncertain significance Single submitter
- PRLHR p.Pro237Ala Uncertain significance Single submitter
- PRLHR p.Pro310Leu Uncertain significance Single submitter
- PRLHR p.Pro359Ser Uncertain significance Single submitter
- PRLHR p.Ser367Gly Uncertain significance Single submitter
- PRLHR p.Ser3Leu Uncertain significance Single submitter
- PRLHR p.Thr5Ser Uncertain significance Single submitter
- PRLHR p.Trp268Arg Uncertain significance Single submitter
- PRLHR p.Tyr67Cys Uncertain significance Single submitter
- PRLHR p.Val162Leu Uncertain significance Single submitter
- PRLHR p.Val240Ile Uncertain significance Single submitter
- PRLHR p.Val246Leu Uncertain significance Single submitter
- PRLHR p.Val316Leu Uncertain significance Single submitter
- PRLHR p.Val47Leu Uncertain significance Single submitter
- PRLHR p.Val56Leu Uncertain significance Single submitter
- PRLHR p.Val70Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PRLHR p.Arg255Ser Uncertain significance Single submitter
- PRLHR p.Glu123Val Uncertain significance Single submitter
- PRLHR p.Glu345Val Uncertain significance Single submitter
- PRLHR p.His339Gln Uncertain significance Single submitter
- PRLHR p.Leu315Gln Uncertain significance Single submitter
- PRLHR p.Phe129Leu Uncertain significance Single submitter
- PRLHR p.Pro258Ser Uncertain significance Single submitter
- PRLHR p.Thr233Ile Uncertain significance Single submitter
- PRLHR p.Tyr245Asn Uncertain significance Single submitter
- PRLHR p.Val147Gly Uncertain significance Single submitter
All PRLHR variants
Benign 1
- p.Leu346= Multiple submitters
Likely benign 1
- p.Val196Met Single submitter
Uncertain significance 61
- p.Ala26Thr Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala358Thr Single submitter ⚠
- p.Ala44Ser Single submitter ⚠
- p.Arg222Ser Single submitter ⚠
- p.Arg247Leu Single submitter ⚠
- p.Arg255Ser Single submitter ⚠
- p.Arg270Gly Single submitter ⚠
- p.Arg272Trp Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg355Leu Single submitter ⚠
- p.Arg89Cys Single submitter
- p.Arg89His Single submitter ⚠
- p.Asn101Ser Single submitter
- p.Asp207Glu Single submitter ⚠
- p.Cys113Tyr Single submitter ⚠
- p.Cys134Tyr Single submitter ⚠
- p.Cys260Tyr Single submitter ⚠
- p.Gln51Arg Single submitter ⚠
- p.Glu123Gln Single submitter ⚠
- p.Glu123Val Single submitter ⚠
- p.Glu345Val Single submitter ⚠
- p.Gly100Ser Single submitter
- p.Gly74Ala Single submitter
- p.His206Gln Single submitter ⚠
- p.His295Leu Single submitter ⚠
- p.His339Gln Single submitter ⚠
- p.His360Arg Single submitter ⚠
- p.His360Tyr Single submitter ⚠
- p.His57Arg Single submitter ⚠
- p.Ile357Arg Single submitter ⚠
- p.Leu14Ile Single submitter ⚠
- p.Leu210Pro Single submitter ⚠
- p.Leu236Phe Single submitter ⚠
- p.Leu315Gln Single submitter ⚠
- p.Leu323Ile Single submitter ⚠
- p.Met109Leu Single submitter ⚠
- p.Met325Val Single submitter ⚠
- p.Met364Val Single submitter ⚠
- p.Phe129Leu Single submitter ⚠
- p.Pro124Ser Single submitter ⚠
- p.Pro237Ala Single submitter ⚠
- p.Pro258Ser Single submitter ⚠
- p.Pro310Leu Single submitter ⚠
- p.Pro359Ser Single submitter ⚠
- p.Ser367Gly Single submitter ⚠
- p.Ser3Leu Single submitter ⚠
- p.Thr233Ile Single submitter ⚠
- p.Thr5Ser Single submitter ⚠
- p.Trp268Arg Single submitter ⚠
- p.Tyr245Asn Single submitter ⚠
- p.Tyr67Cys Single submitter ⚠
- p.Val147Gly Single submitter ⚠
- p.Val162Leu Single submitter ⚠
- p.Val240Ile Single submitter ⚠
- p.Val246Leu Single submitter ⚠
- p.Val316Leu Single submitter ⚠
- p.Val47Leu Single submitter ⚠
- p.Val56Leu Single submitter ⚠
- p.Val70Leu Single submitter ⚠