PRMT1 — 24 ClinVar variants
All ClinVar germline PRMT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Benign · 1 Likely benign · 22 Uncertain significance
Full PRMT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRMT1 p.Ala249Thr Uncertain significance Single submitter
- PRMT1 p.Ala44Pro Uncertain significance Single submitter
- PRMT1 p.Ala7Val Uncertain significance Single submitter
- PRMT1 p.Asn20Lys Uncertain significance Single submitter
- PRMT1 p.Asn43Ser Uncertain significance Single submitter
- PRMT1 p.Glu234Gln Uncertain significance Single submitter
- PRMT1 p.Gly100Ser Uncertain significance Single submitter
- PRMT1 p.Ile142Val Uncertain significance Single submitter
- PRMT1 p.Ile331Val Uncertain significance Single submitter
- PRMT1 p.Met319Leu Uncertain significance Single submitter
- PRMT1 p.Thr140Asn Uncertain significance Single submitter
- PRMT1 p.Thr327Met Uncertain significance Single submitter
- PRMT1 p.Val15Leu Uncertain significance Single submitter
- PRMT1 p.Val246Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- PRMT1 p.Arg112His Uncertain significance Single submitter
- PRMT1 p.Arg206Gln Uncertain significance Single submitter
- PRMT1 p.Arg369Gln Uncertain significance Single submitter
- PRMT1 p.Pro152Leu Uncertain significance Single submitter
- PRMT1 p.Thr140Ala Uncertain significance Single submitter
- PRMT1 p.Val281Met Uncertain significance Single submitter
All PRMT1 variants
Benign 1
- p.Glu45= Multiple submitters
Likely benign 1
- p.Thr327= Single submitter
Uncertain significance 22
- c.911-43_946del Single submitter
- p.Ala249Thr Single submitter ⚠
- p.Ala44Pro Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg195Gln Single submitter
- p.Arg206Gln Single submitter ⚠
- p.Arg369Gln Single submitter ⚠
- p.Asn20Lys Single submitter ⚠
- p.Asn43Ser Single submitter ⚠
- p.Glu234Gln Single submitter ⚠
- p.Gly100Ser Single submitter ⚠
- p.Ile142Val Single submitter ⚠
- p.Ile331Val Single submitter ⚠
- p.Met319Leu Single submitter ⚠
- p.Pro152Leu Single submitter ⚠
- p.Thr140Ala Single submitter ⚠
- p.Thr140Asn Single submitter ⚠
- p.Thr327Met Single submitter ⚠
- p.Val15Leu Single submitter ⚠
- p.Val246Ile Single submitter ⚠
- p.Val281Met Single submitter ⚠