PRMT3 — 64 ClinVar variants
All ClinVar germline PRMT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
1 Benign · 1 Likely benign · 62 Uncertain significance
Full PRMT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRMT3 p.Ala210Glu Uncertain significance Single submitter
- PRMT3 p.Ala276Pro Uncertain significance Single submitter
- PRMT3 p.Ala31Thr Uncertain significance Single submitter
- PRMT3 p.Arg12Gln Uncertain significance Single submitter
- PRMT3 p.Arg180Cys Uncertain significance Single submitter
- PRMT3 p.Arg180His Uncertain significance Single submitter
- PRMT3 p.Arg200Thr Uncertain significance Single submitter
- PRMT3 p.Asn150Ser Uncertain significance Single submitter
- PRMT3 p.Asp261Val Uncertain significance Single submitter
- PRMT3 p.Asp29Asn Uncertain significance Single submitter
- PRMT3 p.Glu136Asp Uncertain significance Single submitter
- PRMT3 p.Gly13Asp Uncertain significance Single submitter
- PRMT3 p.Gly263Val Uncertain significance Single submitter
- PRMT3 p.Gly265Arg Uncertain significance Single submitter
- PRMT3 p.Gly332Asp Uncertain significance Single submitter
- PRMT3 p.His230Arg Uncertain significance Single submitter
- PRMT3 p.His376Tyr Uncertain significance Single submitter
- PRMT3 p.His479Tyr Uncertain significance Single submitter
- PRMT3 p.Ile109Met Uncertain significance Single submitter
- PRMT3 p.Ile229Leu Uncertain significance Single submitter
- PRMT3 p.Ile399Thr Uncertain significance Single submitter
- PRMT3 p.Ile419Val Uncertain significance Single submitter
- PRMT3 p.Ile457Val Uncertain significance Single submitter
- PRMT3 p.Lys301Glu Uncertain significance Single submitter
- PRMT3 p.Lys390Glu Uncertain significance Single submitter
- PRMT3 p.Lys441Asn Uncertain significance Single submitter
- PRMT3 p.Lys509Arg Uncertain significance Single submitter
- PRMT3 p.Met165Val Uncertain significance Single submitter
- PRMT3 p.Met271Leu Uncertain significance Single submitter
- PRMT3 p.Met340Ile Uncertain significance Single submitter
- PRMT3 p.Phe254Leu Uncertain significance Single submitter
- PRMT3 p.Phe469Leu Uncertain significance Single submitter
- PRMT3 p.Pro145Arg Uncertain significance Single submitter
- PRMT3 p.Pro490Thr Uncertain significance Single submitter
- PRMT3 p.Pro512Ser Uncertain significance Single submitter
- PRMT3 p.Ser203Leu Uncertain significance Single submitter
- PRMT3 p.Ser343Phe Uncertain significance Single submitter
- PRMT3 p.Ser492Ala Uncertain significance Single submitter
- PRMT3 p.Thr156Ile Uncertain significance Single submitter
- PRMT3 p.Thr197Pro Uncertain significance Single submitter
- PRMT3 p.Thr427Met Uncertain significance Single submitter
- PRMT3 p.Thr471Met Uncertain significance Single submitter
- PRMT3 p.Thr525Ala Uncertain significance Single submitter
- PRMT3 p.Tyr458Cys Uncertain significance Single submitter
- PRMT3 p.Val103Gly Uncertain significance Single submitter
- PRMT3 p.Val142Leu Uncertain significance Single submitter
- PRMT3 p.Val284Ala Uncertain significance Single submitter
- PRMT3 p.Val325Phe Uncertain significance Single submitter
- PRMT3 p.Val484Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PRMT3 p.Ala175Thr Uncertain significance Single submitter
- PRMT3 p.Asp378Asn Uncertain significance Single submitter
- PRMT3 p.His252Arg Uncertain significance Single submitter
- PRMT3 p.Ile109Thr Uncertain significance Single submitter
- PRMT3 p.Leu51Val Uncertain significance Single submitter
- PRMT3 p.Lys348Glu Uncertain significance Single submitter
- PRMT3 p.Pro141Leu Uncertain significance Single submitter
- PRMT3 p.Pro416Arg Uncertain significance Single submitter
- PRMT3 p.Ser27Arg Uncertain significance Single submitter
- PRMT3 p.Tyr291His Uncertain significance Single submitter
All PRMT3 variants
Benign 1
- p.Ala210Val Multiple submitters
Likely benign 1
- p.Thr197Ala Single submitter
Uncertain significance 62
- p.Ala175Thr Single submitter ⚠
- p.Ala210Glu Single submitter ⚠
- p.Ala276Pro Single submitter ⚠
- p.Ala31Thr Single submitter ⚠
- p.Arg12Gln Single submitter ⚠
- p.Arg180Cys Single submitter ⚠
- p.Arg180His Single submitter ⚠
- p.Arg200Thr Single submitter ⚠
- p.Arg244Gln Single submitter
- p.Asn150Ser Single submitter ⚠
- p.Asp261Val Single submitter ⚠
- p.Asp29Asn Single submitter ⚠
- p.Asp378Asn Single submitter ⚠
- p.Glu136Asp Single submitter ⚠
- p.Gly13Asp Single submitter ⚠
- p.Gly263Val Single submitter ⚠
- p.Gly265Arg Single submitter ⚠
- p.Gly332Asp Single submitter ⚠
- p.His230Arg Single submitter ⚠
- p.His252Arg Single submitter ⚠
- p.His376Tyr Single submitter ⚠
- p.His479Tyr Single submitter ⚠
- p.Ile109Met Single submitter ⚠
- p.Ile109Thr Single submitter ⚠
- p.Ile229Leu Single submitter ⚠
- p.Ile399Thr Single submitter ⚠
- p.Ile419Val Single submitter ⚠
- p.Ile457Val Single submitter ⚠
- p.Leu51Val Single submitter ⚠
- p.Lys301Glu Single submitter ⚠
- p.Lys348Glu Single submitter ⚠
- p.Lys390Glu Single submitter ⚠
- p.Lys441Asn Single submitter ⚠
- p.Lys509Arg Single submitter ⚠
- p.Met165Val Single submitter ⚠
- p.Met271Leu Single submitter ⚠
- p.Met340Ile Single submitter ⚠
- p.Phe254Leu Single submitter ⚠
- p.Phe469Leu Single submitter ⚠
- p.Pro141Leu Single submitter ⚠
- p.Pro145Arg Single submitter ⚠
- p.Pro416Arg Single submitter ⚠
- p.Pro490Thr Single submitter ⚠
- p.Pro512Ser Single submitter ⚠
- p.Ser203Leu Single submitter ⚠
- p.Ser27Arg Single submitter ⚠
- p.Ser343Phe Single submitter ⚠
- p.Ser492Ala Single submitter ⚠
- p.Thr156Ile Single submitter ⚠
- p.Thr197Pro Single submitter ⚠
- p.Thr427Met Single submitter ⚠
- p.Thr471Met Single submitter ⚠
- p.Thr525Ala Single submitter ⚠
- p.Tyr291His Single submitter ⚠
- p.Tyr351His Single submitter
- p.Tyr458Cys Single submitter ⚠
- p.Val103Gly Single submitter ⚠
- p.Val142Leu Single submitter ⚠
- p.Val284Ala Single submitter ⚠
- p.Val325Phe Single submitter ⚠
- p.Val484Leu Single submitter ⚠
- p.Val517Met Single submitter