PRMT5 — 38 ClinVar variants
All ClinVar germline PRMT5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
3 Benign · 3 Likely benign · 32 Uncertain significance
Full PRMT5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRMT5 p.Ala9Gly Uncertain significance Single submitter
- PRMT5 p.Arg601His Uncertain significance Single submitter
- PRMT5 p.Arg631Cys Uncertain significance Single submitter
- PRMT5 p.Asn61Asp Uncertain significance Single submitter
- PRMT5 p.Cys622Ser Uncertain significance Single submitter
- PRMT5 p.Gly10Ser Uncertain significance Single submitter
- PRMT5 p.Ile341Val Uncertain significance Single submitter
- PRMT5 p.Lys610Asn Uncertain significance Single submitter
- PRMT5 p.Lys610Gln Uncertain significance Single submitter
- PRMT5 p.Met529Thr Uncertain significance Single submitter
- PRMT5 p.Pro350Ser Uncertain significance Single submitter
- PRMT5 p.Ser273Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- PRMT5 p.Ala552Ser Uncertain significance Single submitter
- PRMT5 p.Arg377Gln Uncertain significance Single submitter
- PRMT5 p.Arg384Gln Uncertain significance Single submitter
- PRMT5 p.Arg385Gln Uncertain significance Single submitter
- PRMT5 p.Arg385Trp Uncertain significance Single submitter
- PRMT5 p.Arg492His Uncertain significance Single submitter
- PRMT5 p.Arg593Cys Uncertain significance Single submitter
- PRMT5 p.Arg62Pro Uncertain significance Single submitter
- PRMT5 p.Asn482Asp Uncertain significance Single submitter
- PRMT5 p.Asp347Glu Uncertain significance Single submitter
- PRMT5 p.Gly114Val Uncertain significance Single submitter
- PRMT5 p.Gly595Ser Uncertain significance Single submitter
- PRMT5 p.Gly7Glu Uncertain significance Single submitter
- PRMT5 p.His147Tyr Uncertain significance Single submitter
- PRMT5 p.Ile99Thr Uncertain significance Single submitter
- PRMT5 p.Lys354Thr Uncertain significance Single submitter
- PRMT5 p.Phe54Val Uncertain significance Single submitter
- PRMT5 p.Ser608Phe Uncertain significance Single submitter
- PRMT5 p.Thr564Ile Uncertain significance Single submitter
- PRMT5 p.Val433Ile Uncertain significance Single submitter
All PRMT5 variants
Likely benign 3
- c.1579+6T>G Single submitter
- c.940-5A>G Single submitter
- p.Met529Val Single submitter
Uncertain significance 32
- p.Ala552Ser Single submitter ⚠
- p.Ala9Gly Single submitter ⚠
- p.Arg377Gln Single submitter ⚠
- p.Arg384Gln Single submitter ⚠
- p.Arg385Gln Single submitter ⚠
- p.Arg385Trp Single submitter ⚠
- p.Arg492His Single submitter ⚠
- p.Arg593Cys Single submitter ⚠
- p.Arg601His Single submitter ⚠
- p.Arg62Pro Single submitter ⚠
- p.Arg631Cys Single submitter ⚠
- p.Asn482Asp Single submitter ⚠
- p.Asn61Asp Single submitter ⚠
- p.Asp347Glu Single submitter ⚠
- p.Cys622Ser Single submitter ⚠
- p.Gly10Ser Single submitter ⚠
- p.Gly114Val Single submitter ⚠
- p.Gly595Ser Single submitter ⚠
- p.Gly7Glu Single submitter ⚠
- p.His147Tyr Single submitter ⚠
- p.Ile341Val Single submitter ⚠
- p.Ile99Thr Single submitter ⚠
- p.Lys354Thr Single submitter ⚠
- p.Lys610Asn Single submitter ⚠
- p.Lys610Gln Single submitter ⚠
- p.Met529Thr Single submitter ⚠
- p.Phe54Val Single submitter ⚠
- p.Pro350Ser Single submitter ⚠
- p.Ser273Leu Single submitter ⚠
- p.Ser608Phe Single submitter ⚠
- p.Thr564Ile Single submitter ⚠
- p.Val433Ile Single submitter ⚠