PRMT6 — 47 ClinVar variants
All ClinVar germline PRMT6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
1 Benign · 4 Likely benign · 42 Uncertain significance
Full PRMT6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRMT6 p.Ala254Gly Uncertain significance Single submitter
- PRMT6 p.Ala261Pro Uncertain significance Single submitter
- PRMT6 p.Ala261Thr Uncertain significance Single submitter
- PRMT6 p.Ala315Ser Uncertain significance Single submitter
- PRMT6 p.Ala321Gly Uncertain significance Single submitter
- PRMT6 p.Arg347Gly Uncertain significance Single submitter
- PRMT6 p.Arg351His Uncertain significance Single submitter
- PRMT6 p.Arg352Leu Uncertain significance Single submitter
- PRMT6 p.Arg43Trp Uncertain significance Single submitter
- PRMT6 p.Asp348Gly Uncertain significance Single submitter
- PRMT6 p.Asp370Asn Uncertain significance Single submitter
- PRMT6 p.Gln265Leu Uncertain significance Single submitter
- PRMT6 p.Glu23Gln Uncertain significance Single submitter
- PRMT6 p.Glu327Lys Uncertain significance Single submitter
- PRMT6 p.Gly12Arg Uncertain significance Single submitter
- PRMT6 p.Gly20Arg Uncertain significance Single submitter
- PRMT6 p.Gly298Arg Uncertain significance Single submitter
- PRMT6 p.Gly298Glu Uncertain significance Single submitter
- PRMT6 p.Ile290Met Uncertain significance Single submitter
- PRMT6 p.Lys367Gln Uncertain significance Single submitter
- PRMT6 p.Lys5Arg Uncertain significance Single submitter
- PRMT6 p.Met285Val Uncertain significance Single submitter
- PRMT6 p.Pro137Leu Uncertain significance Single submitter
- PRMT6 p.Pro284His Uncertain significance Single submitter
- PRMT6 p.Pro311Leu Uncertain significance Single submitter
- PRMT6 p.Pro314Leu Uncertain significance Single submitter
- PRMT6 p.Ser282Leu Uncertain significance Single submitter
- PRMT6 p.Thr85Lys Uncertain significance Single submitter
- PRMT6 p.Val54Phe Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- PRMT6 p.Arg347Trp Uncertain significance Single submitter
- PRMT6 p.Arg37Gly Uncertain significance Single submitter
- PRMT6 p.Asn349Lys Uncertain significance Single submitter
- PRMT6 p.Gly12Trp Uncertain significance Single submitter
- PRMT6 p.Gly273Val Uncertain significance Single submitter
- PRMT6 p.Gly281Asp Uncertain significance Single submitter
- PRMT6 p.Gly83Ser Uncertain significance Single submitter
- PRMT6 p.His286Gln Uncertain significance Single submitter
- PRMT6 p.Leu263Ser Uncertain significance Single submitter
- PRMT6 p.Phe371Leu Uncertain significance Single submitter
- PRMT6 p.Ser52Leu Uncertain significance Single submitter
- PRMT6 p.Thr335Arg Uncertain significance Single submitter
All PRMT6 variants
Benign 1
- p.Pro314= No assertion criteria PRMT6-related disorder
Likely benign 4
- p.Met285Leu Single submitter
- c.-8C>T No assertion criteria PRMT6-related disorder
- p.Gly12= No assertion criteria PRMT6-related disorder
- p.Leu9Val No assertion criteria PRMT6-related disorder
Uncertain significance 42
- p.Ala254Gly Single submitter ⚠
- p.Ala261Pro Single submitter ⚠
- p.Ala261Thr Single submitter ⚠
- p.Ala315Ser Single submitter ⚠
- p.Ala321Gly Single submitter ⚠
- p.Arg347Gly Single submitter ⚠
- p.Arg347Trp Single submitter ⚠
- p.Arg351His Single submitter ⚠
- p.Arg352Leu Single submitter ⚠
- p.Arg37Gly Single submitter ⚠
- p.Arg43Trp Single submitter ⚠
- p.Asn349Lys Single submitter ⚠
- p.Asp348Gly Single submitter ⚠
- p.Asp370Asn Single submitter ⚠
- p.Gln265Leu Single submitter ⚠
- p.Glu23Gln Single submitter ⚠
- p.Glu327Lys Single submitter ⚠
- p.Gly12Arg Single submitter ⚠
- p.Gly12Trp Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly273Val Single submitter ⚠
- p.Gly281Asp Single submitter ⚠
- p.Gly298Arg Single submitter ⚠
- p.Gly298Glu Single submitter ⚠
- p.Gly83Ser Single submitter ⚠
- p.His286Gln Single submitter ⚠
- p.Ile290Met Single submitter ⚠
- p.Leu263Ser Single submitter ⚠
- p.Leu322Phe Single submitter
- p.Lys367Gln Single submitter ⚠
- p.Lys5Arg Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Phe371Leu Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Pro284His Single submitter ⚠
- p.Pro311Leu Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Ser282Leu Single submitter ⚠
- p.Ser52Leu Single submitter ⚠
- p.Thr335Arg Single submitter ⚠
- p.Thr85Lys Single submitter ⚠
- p.Val54Phe Single submitter ⚠