PRMT8 — 32 ClinVar variants
All ClinVar germline PRMT8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
3 Benign · 1 Likely benign · 28 Uncertain significance
Full PRMT8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRMT8 p.Ala17Thr Uncertain significance Single submitter
- PRMT8 p.Ala306Thr Uncertain significance Single submitter
- PRMT8 p.Arg251Trp Uncertain significance Single submitter
- PRMT8 p.Arg300Cys Uncertain significance Single submitter
- PRMT8 p.Arg349Gln Uncertain significance Single submitter
- PRMT8 p.Asn160Asp Uncertain significance Single submitter
- PRMT8 p.Asn160His Uncertain significance Single submitter
- PRMT8 p.Asp329Glu Uncertain significance Single submitter
- PRMT8 p.Ile140Met Uncertain significance Single submitter
- PRMT8 p.Ile280Val Uncertain significance Single submitter
- PRMT8 p.Leu213Phe Uncertain significance Single submitter
- PRMT8 p.Met322Val Uncertain significance Single submitter
- PRMT8 p.Phe165Leu Uncertain significance Single submitter
- PRMT8 p.Pro33Arg Uncertain significance Single submitter
- PRMT8 p.Pro33His Uncertain significance Single submitter
- PRMT8 p.Pro33Ser Uncertain significance Single submitter
- PRMT8 p.Pro34Leu Uncertain significance Single submitter
- PRMT8 p.Thr285Met Uncertain significance Single submitter
- PRMT8 p.Val223Met Uncertain significance Single submitter
- PRMT8 p.Val253Met Uncertain significance Single submitter
- PRMT8 p.Val37Ile Uncertain significance Single submitter
- PRMT8 p.Val43Met Uncertain significance Single submitter
- PRMT8 p.Val46Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All PRMT8 variants
Likely benign 1
- p.Val304Ile Single submitter
Uncertain significance 28
- p.Ala17Glu Single submitter ⚠
- p.Ala17Thr Single submitter ⚠
- p.Ala306Thr Single submitter ⚠
- p.Arg251Trp Single submitter ⚠
- p.Arg300Cys Single submitter ⚠
- p.Arg349Gln Single submitter ⚠
- p.Asn160Asp Single submitter ⚠
- p.Asn160His Single submitter ⚠
- p.Asp233Glu Single submitter ⚠
- p.Asp329Glu Single submitter ⚠
- p.Gln230fs Single submitter
- p.Ile140Met Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Leu213Phe Single submitter ⚠
- p.Lys365Glu Single submitter ⚠
- p.Met322Val Single submitter ⚠
- p.Phe165Leu Single submitter ⚠
- p.Pro33Arg Single submitter ⚠
- p.Pro33His Single submitter ⚠
- p.Pro33Ser Single submitter ⚠
- p.Pro34Leu Single submitter ⚠
- p.Thr285Met Single submitter ⚠
- p.Val176Met Single submitter ⚠
- p.Val223Met Single submitter ⚠
- p.Val253Met Single submitter ⚠
- p.Val37Ile Single submitter ⚠
- p.Val43Met Single submitter ⚠
- p.Val46Ile Single submitter ⚠