PRP4K — 46 ClinVar variants
All ClinVar germline PRP4K variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
2 Benign · 6 Likely benign · 38 Uncertain significance
Full PRP4K gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PRP4K p.Arg10Trp Uncertain significance Single submitter
- PRP4K p.Arg183Gln Uncertain significance Single submitter
- PRP4K p.Arg308Gln Uncertain significance Single submitter
- PRP4K p.Arg308Gly Uncertain significance Single submitter
- PRP4K p.Arg344Gly Uncertain significance Single submitter
- PRP4K p.Arg348His Uncertain significance Single submitter
- PRP4K p.Arg364Lys Uncertain significance Single submitter
- PRP4K p.Arg367Ser Uncertain significance Single submitter
- PRP4K p.Arg374Gly Uncertain significance Single submitter
- PRP4K p.Arg399Thr Uncertain significance Single submitter
- PRP4K p.Arg401Gln Uncertain significance Single submitter
- PRP4K p.Arg408Gln Uncertain significance Single submitter
- PRP4K p.Arg417Gln Uncertain significance Single submitter
- PRP4K p.Arg464Ser Uncertain significance Single submitter
- PRP4K p.Arg469Gln Uncertain significance Single submitter
- PRP4K p.Asp273Gly Uncertain significance Single submitter
- PRP4K p.Glu825Val Uncertain significance Single submitter
- PRP4K p.Gly347Ala Uncertain significance Single submitter
- PRP4K p.Gly916Val Uncertain significance Single submitter
- PRP4K p.His78Arg Uncertain significance Single submitter
- PRP4K p.Ile178Val Uncertain significance Single submitter
- PRP4K p.Ile265Thr Uncertain significance Single submitter
- PRP4K p.Leu173Pro Uncertain significance Single submitter
- PRP4K p.Leu763Phe Uncertain significance Single submitter
- PRP4K p.Lys209Glu Uncertain significance Single submitter
- PRP4K p.Lys58Arg Uncertain significance Single submitter
- PRP4K p.Met125Ile Uncertain significance Single submitter
- PRP4K p.Met930Ile Uncertain significance Single submitter
- PRP4K p.Pro454Ser Uncertain significance Single submitter
- PRP4K p.Ser302Pro Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PRP4K variants
Likely benign 6
- c.2175-4T>G Single submitter
- p.Arg305Gly Single submitter
- p.Arg440= Single submitter
- p.Arg464= Single submitter
- p.Arg488= Single submitter
- p.Ser166Gly Single submitter
Uncertain significance 38
- p.Ala671Thr Single submitter
- p.Arg10Trp Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg191Trp Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg308Gly Single submitter ⚠
- p.Arg344Gly Single submitter ⚠
- p.Arg348His Single submitter ⚠
- p.Arg364Lys Single submitter ⚠
- p.Arg367Ser Single submitter ⚠
- p.Arg374Gly Single submitter ⚠
- p.Arg384Trp Single submitter ⚠
- p.Arg399Thr Single submitter ⚠
- p.Arg401Gln Single submitter ⚠
- p.Arg408Gln Single submitter ⚠
- p.Arg417Gln Single submitter ⚠
- p.Arg424His Single submitter ⚠
- p.Arg440Gln Single submitter ⚠
- p.Arg464Ser Single submitter ⚠
- p.Arg469Gln Single submitter ⚠
- p.Arg480Cys Single submitter ⚠
- p.Arg482Pro Single submitter
- p.Arg577Ter Single submitter
- p.Asp273Gly Single submitter ⚠
- p.Glu825Val Single submitter ⚠
- p.Gly347Ala Single submitter ⚠
- p.Gly916Val Single submitter ⚠
- p.His78Arg Single submitter ⚠
- p.Ile178Val Single submitter ⚠
- p.Ile265Thr Single submitter ⚠
- p.Leu173Pro Single submitter ⚠
- p.Leu763Phe Single submitter ⚠
- p.Lys209Glu Single submitter ⚠
- p.Lys58Arg Single submitter ⚠
- p.Met125Ile Single submitter ⚠
- p.Met930Ile Single submitter ⚠
- p.Pro454Ser Single submitter ⚠
- p.Ser302Pro Single submitter ⚠