PRSS3 — 13 ClinVar variants
All ClinVar germline PRSS3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1 flagged for review →
11 Benign · 1 Likely benign · 1 Uncertain significance
Full PRSS3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 1
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All PRSS3 variants
Benign 11
- c.200+112A>G Multiple submitters
- c.201-66G>A Multiple submitters
- c.592-188T>C Multiple submitters
- c.-285+120G>C Multiple submitters
- c.-47+23G>T Multiple submitters
- p.Ala17= Multiple submitters
- c.200+256A>T Single submitter
- c.201-66G>T Single submitter
- c.-285+290C>A Single submitter
- p.Glu32del Single submitter
- p.Thr131Ala Single submitter
Likely benign 1
- c.591+35C>T Single submitter
Uncertain significance 1
- p.Val25Ala Single submitter thyroiditis ⚠