PSMA5 — 9 ClinVar variants
All ClinVar germline PSMA5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
9 Uncertain significance
Full PSMA5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMA5 p.Gln224Arg Uncertain significance Single submitter
- PSMA5 p.Glu148Asp Uncertain significance Single submitter
- PSMA5 p.Lys149Asn Uncertain significance Single submitter
- PSMA5 p.Thr219Ala Uncertain significance Single submitter
- PSMA5 p.Val163Ile Uncertain significance Single submitter
- PSMA5 p.Val68Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All PSMA5 variants
Uncertain significance 9
- p.Gln224Arg Single submitter ⚠
- p.Glu148Asp Single submitter ⚠
- p.Lys149Asn Single submitter ⚠
- p.Met107Val Single submitter ⚠
- p.Pro61Thr Single submitter ⚠
- p.Thr219Ala Single submitter ⚠
- p.Thr87Ile Single submitter ⚠
- p.Val163Ile Single submitter ⚠
- p.Val68Ile Single submitter ⚠