PSMB11 — 69 ClinVar variants

All ClinVar germline PSMB11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →

4 Benign · 1 Benign/Likely benign · 5 Likely benign · 59 Uncertain significance

Full PSMB11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 55

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 45

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All PSMB11 variants

Benign 4

p.Ala203Thr Multiple submitters
p.Ala208Thr Multiple submitters
p.Tyr162= Multiple submitters
p.Ser80fs Single submitter

Benign/Likely benign 1

p.Gly49Ser Multiple submitters

Likely benign 5

p.Arg115Gln Single submitter
p.Arg23Gln Single submitter
p.Cys81Arg Single submitter
p.Gly296Glu Single submitter
p.Val246Met Single submitter

Uncertain significance 59

p.Ala212Thr Single submitter ⚠
p.Ala24Pro Single submitter ⚠
p.Ala274Thr Single submitter ⚠
p.Arg110Gln Single submitter ⚠
p.Arg115Trp Single submitter ⚠
p.Arg155Cys Single submitter ⚠
p.Arg193Cys Single submitter ⚠
p.Arg193His Single submitter ⚠
p.Arg206His Single submitter ⚠
p.Arg215Cys Single submitter
p.Arg215His Single submitter ⚠
p.Arg229Gln Single submitter ⚠
p.Arg238Cys Single submitter ⚠
p.Arg31Gln Single submitter ⚠
p.Arg56His Single submitter ⚠
p.Arg68His Single submitter
p.Asp166Val Single submitter ⚠
p.Asp195Asn Single submitter ⚠
p.Asp240Asn Single submitter ⚠
p.Asp259Gly Single submitter ⚠
p.Asp5Val Single submitter ⚠
p.Cys145Tyr Single submitter ⚠
p.Cys33Gly Single submitter ⚠
p.Gln138His Single submitter ⚠
p.Gln138Pro Single submitter ⚠
p.Gln40His Single submitter ⚠
p.Glu253Lys Single submitter ⚠
p.Gly120Ser Single submitter ⚠
p.Gly167Ser Single submitter ⚠
p.Gly191Asp Single submitter ⚠
p.Gly221Cys Single submitter
p.Gly32Ser Single submitter ⚠
p.His42Arg Single submitter ⚠
p.His87Leu Single submitter
p.His89Asn Single submitter ⚠
p.Ile84Asn Single submitter ⚠
p.Leu132Phe Single submitter ⚠
p.Leu144Phe Single submitter ⚠
p.Phe161Leu Single submitter ⚠
p.Pro123Leu Single submitter ⚠
p.Pro30Arg Single submitter ⚠
p.Pro35Leu Single submitter ⚠
p.Pro44Ser Single submitter ⚠
p.Ser18Pro Single submitter ⚠
p.Thr14Ser Single submitter ⚠
p.Thr213Ile Single submitter ⚠
p.Thr299Met Single submitter ⚠
p.Thr37Asn Single submitter ⚠
p.Thr51Ala Single submitter ⚠
p.Thr51Ile Single submitter ⚠
p.Thr67Lys Single submitter ⚠
p.Thr67Met Single submitter ⚠
p.Thr94Asn Single submitter ⚠
p.Tyr139Ser Single submitter ⚠
p.Tyr202His Single submitter ⚠
p.Val163Ile Single submitter ⚠
p.Val228Met Single submitter ⚠
p.Val75Met Single submitter ⚠
p.Val86Met Single submitter ⚠