PSMB2 — 19 ClinVar variants
All ClinVar germline PSMB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
19 Uncertain significance
Full PSMB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMB2 p.Ala114Val Uncertain significance Single submitter
- PSMB2 p.Ala156Val Uncertain significance Single submitter
- PSMB2 p.Asp108His Uncertain significance Single submitter
- PSMB2 p.Asp190Asn Uncertain significance Single submitter
- PSMB2 p.Gly135Ser Uncertain significance Single submitter
- PSMB2 p.Gly200Val Uncertain significance Single submitter
- PSMB2 p.Gly48Arg Uncertain significance Single submitter
- PSMB2 p.Ile151Met Uncertain significance Single submitter
- PSMB2 p.Ile172Val Uncertain significance Single submitter
- PSMB2 p.Leu159Phe Uncertain significance Single submitter
- PSMB2 p.Leu4Val Uncertain significance Single submitter
- PSMB2 p.Lys162Glu Uncertain significance Single submitter
- PSMB2 p.Lys162Thr Uncertain significance Single submitter
- PSMB2 p.Ser201Tyr Uncertain significance Single submitter
- PSMB2 p.Val47Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All PSMB2 variants
Uncertain significance 19
- p.Ala114Val Single submitter ⚠
- p.Ala156Thr Single submitter
- p.Ala156Val Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Asp108His Single submitter ⚠
- p.Asp190Asn Single submitter ⚠
- p.Gly135Ser Single submitter ⚠
- p.Gly200Val Single submitter ⚠
- p.Gly48Arg Single submitter ⚠
- p.Ile151Met Single submitter ⚠
- p.Ile172Val Single submitter ⚠
- p.Leu140Phe Single submitter ⚠
- p.Leu159Phe Single submitter ⚠
- p.Leu4Val Single submitter ⚠
- p.Lys162Glu Single submitter ⚠
- p.Lys162Thr Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Ser201Tyr Single submitter ⚠
- p.Val47Ala Single submitter ⚠