PSMB3 — 21 ClinVar variants
All ClinVar germline PSMB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
2 Likely benign · 19 Uncertain significance
Full PSMB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMB3 p.Asp135Tyr Uncertain significance Single submitter
- PSMB3 p.Gln31His Uncertain significance Single submitter
- PSMB3 p.Glu144Lys Uncertain significance Single submitter
- PSMB3 p.Ile186Thr Uncertain significance Single submitter
- PSMB3 p.Ile3Val Uncertain significance Single submitter
- PSMB3 p.Met14Thr Uncertain significance Single submitter
- PSMB3 p.Met45Leu Uncertain significance Single submitter
- PSMB3 p.Thr199Ala Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- PSMB3 p.Arg26Ser Uncertain significance Single submitter
- PSMB3 p.Arg66His Uncertain significance Single submitter
- PSMB3 p.Arg66Ser Uncertain significance Single submitter
- PSMB3 p.Glu191Lys Uncertain significance Single submitter
- PSMB3 p.Leu200Met Uncertain significance Single submitter
- PSMB3 p.Leu73Val Uncertain significance Single submitter
- PSMB3 p.Lys68Asn Uncertain significance Single submitter
- PSMB3 p.Lys68Glu Uncertain significance Single submitter
- PSMB3 p.Pro114Leu Uncertain significance Single submitter
All PSMB3 variants
Uncertain significance 19
- p.Arg26Ser Single submitter ⚠
- p.Arg66His Single submitter ⚠
- p.Arg66Ser Single submitter ⚠
- p.Asn7Ser Single submitter
- p.Asp135Tyr Single submitter ⚠
- p.Gln31His Single submitter ⚠
- p.Glu144Lys Single submitter ⚠
- p.Glu191Lys Single submitter ⚠
- p.Ile186Thr Single submitter ⚠
- p.Ile3Val Single submitter ⚠
- p.Leu200Met Single submitter ⚠
- p.Leu73Val Single submitter ⚠
- p.Lys68Asn Single submitter ⚠
- p.Lys68Glu Single submitter ⚠
- p.Met146Val Single submitter
- p.Met14Thr Single submitter ⚠
- p.Met45Leu Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Thr199Ala Single submitter ⚠