PSMB6 — 34 ClinVar variants
All ClinVar germline PSMB6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
3 Likely benign · 31 Uncertain significance
Full PSMB6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMB6 p.Ala135Pro Uncertain significance Single submitter
- PSMB6 p.Ala234Asp Uncertain significance Single submitter
- PSMB6 p.Ala39Val Uncertain significance Single submitter
- PSMB6 p.Ala90Val Uncertain significance Single submitter
- PSMB6 p.Arg220Gln Uncertain significance Single submitter
- PSMB6 p.Arg9Leu Uncertain significance Single submitter
- PSMB6 p.Arg9Trp Uncertain significance Single submitter
- PSMB6 p.Asn62Ser Uncertain significance Single submitter
- PSMB6 p.Asp127Gly Uncertain significance Single submitter
- PSMB6 p.Gln188Lys Uncertain significance Single submitter
- PSMB6 p.Gly151Glu Uncertain significance Single submitter
- PSMB6 p.Gly44Trp Uncertain significance Single submitter
- PSMB6 p.Ile161Val Uncertain significance Single submitter
- PSMB6 p.Ile213Ser Uncertain significance Single submitter
- PSMB6 p.Leu210Val Uncertain significance Single submitter
- PSMB6 p.Lys183Arg Uncertain significance Single submitter
- PSMB6 p.Met150Ile Uncertain significance Single submitter
- PSMB6 p.Met38Val Uncertain significance Single submitter
- PSMB6 p.Pro70Arg Uncertain significance Single submitter
- PSMB6 p.Thr235Ala Uncertain significance Single submitter
- PSMB6 p.Thr36Ala Uncertain significance Single submitter
- PSMB6 p.Thr4Ala Uncertain significance Single submitter
- PSMB6 p.Val155Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- PSMB6 p.Ala130Val Uncertain significance Single submitter
- PSMB6 p.Arg178Gln Uncertain significance Single submitter
- PSMB6 p.Glu30Lys Uncertain significance Single submitter
- PSMB6 p.Met129Ile Uncertain significance Single submitter
- PSMB6 p.Phe189Leu Uncertain significance Single submitter
- PSMB6 p.Ser167Phe Uncertain significance Single submitter
All PSMB6 variants
Likely benign 3
- p.Ala232Thr Single submitter
- p.Arg74His Single submitter
- p.Val233Ile Single submitter
Uncertain significance 31
- p.Ala130Val Single submitter ⚠
- p.Ala135Pro Single submitter ⚠
- p.Ala234Asp Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Ala90Val Single submitter ⚠
- p.Arg178Gln Single submitter ⚠
- p.Arg178Trp Single submitter
- p.Arg220Gln Single submitter ⚠
- p.Arg9Leu Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asn62Ser Single submitter ⚠
- p.Asp127Gly Single submitter ⚠
- p.Gln188Lys Single submitter ⚠
- p.Glu30Lys Single submitter ⚠
- p.Gly142Ala Single submitter
- p.Gly151Glu Single submitter ⚠
- p.Gly44Trp Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile213Ser Single submitter ⚠
- p.Leu210Val Single submitter ⚠
- p.Lys183Arg Single submitter ⚠
- p.Met129Ile Single submitter ⚠
- p.Met150Ile Single submitter ⚠
- p.Met38Val Single submitter ⚠
- p.Phe189Leu Single submitter ⚠
- p.Pro70Arg Single submitter ⚠
- p.Ser167Phe Single submitter ⚠
- p.Thr235Ala Single submitter ⚠
- p.Thr36Ala Single submitter ⚠
- p.Thr4Ala Single submitter ⚠
- p.Val155Ile Single submitter ⚠