PSMB7 — 8 ClinVar variants
All ClinVar germline PSMB7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full PSMB7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMB7 p.Ala8Pro Uncertain significance Single submitter
- PSMB7 p.Ala8Ser Uncertain significance Single submitter
- PSMB7 p.Glu263Gln Uncertain significance Single submitter
- PSMB7 p.Leu267Gln Uncertain significance Single submitter
- PSMB7 p.Tyr7Phe Uncertain significance Single submitter
- PSMB7 p.Val6Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.