Sugi Variant

Sugi Variant/PSMB9

PSMB9 — 59 ClinVar variants

All ClinVar germline PSMB9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →

1 Pathogenic · 1 Likely pathogenic · 3 Conflicting · 7 Benign · 2 Benign/Likely benign · 11 Likely benign · 34 Uncertain significance

Full PSMB9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 34

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 24

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 8

The independent predictors disagree with each other — read with care.

All PSMB9 variants

Pathogenic 1

  • p.Gly156Asp No assertion criteria proteasome-associated autoinflammatory syndrome 6

Likely pathogenic 1

Conflicting classifications of pathogenicity 3

Benign 7

Benign/Likely benign 2

  • p.Arg60His Multiple submitters proteasome-associated autoinflammatory syndrome 3
  • p.Val32Ile Multiple submitters ⚠

Likely benign 11

Uncertain significance 34