Sugi Variant

Sugi Variant/PSMC3IP

PSMC3IP — 64 ClinVar variants

All ClinVar germline PSMC3IP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →

4 Pathogenic · 2 Likely pathogenic · 2 Conflicting · 11 Benign · 12 Likely benign · 33 Uncertain significance

Full PSMC3IP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 34

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 27

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 5

The independent predictors disagree with each other — read with care.

All PSMC3IP variants

Pathogenic 4

Likely pathogenic 2

Conflicting classifications of pathogenicity 2

Benign 11

Likely benign 12

Uncertain significance 33