PSMD9 — 42 ClinVar variants
All ClinVar germline PSMD9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
5 Likely benign · 37 Uncertain significance
Full PSMD9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMD9 p.Ala109Val Uncertain significance Single submitter
- PSMD9 p.Ala148Val Uncertain significance Single submitter
- PSMD9 p.Ala15Thr Uncertain significance Single submitter
- PSMD9 p.Arg110Gln Uncertain significance Single submitter
- PSMD9 p.Arg122Leu Uncertain significance Single submitter
- PSMD9 p.Asn217Ser Uncertain significance Single submitter
- PSMD9 p.Asn84His Uncertain significance Single submitter
- PSMD9 p.Asp104Asn Uncertain significance Single submitter
- PSMD9 p.Gly145Ser Uncertain significance Single submitter
- PSMD9 p.His101Arg Uncertain significance Single submitter
- PSMD9 p.Ile142Val Uncertain significance Single submitter
- PSMD9 p.Ile50Thr Uncertain significance Single submitter
- PSMD9 p.Leu26Val Uncertain significance Single submitter
- PSMD9 p.Leu69Pro Uncertain significance Single submitter
- PSMD9 p.Lys123Gln Uncertain significance Single submitter
- PSMD9 p.Lys198Asn Uncertain significance Single submitter
- PSMD9 p.Met112Lys Uncertain significance Single submitter
- PSMD9 p.Met120Leu Uncertain significance Single submitter
- PSMD9 p.Phe162Leu Uncertain significance Single submitter
- PSMD9 p.Pro133Ser Uncertain significance Single submitter
- PSMD9 p.Pro187Ser Uncertain significance Single submitter
- PSMD9 p.Ser13Leu Uncertain significance Single submitter
- PSMD9 p.Ser143Asn Uncertain significance Single submitter
- PSMD9 p.Thr191Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PSMD9 p.Ala75Thr Uncertain significance Single submitter
- PSMD9 p.Arg103Cys Uncertain significance Single submitter
- PSMD9 p.Gln171Pro Uncertain significance Single submitter
- PSMD9 p.Gly210Ala Uncertain significance Single submitter
- PSMD9 p.Lys186Asn Uncertain significance Single submitter
- PSMD9 p.Lys38Glu Uncertain significance Single submitter
- PSMD9 p.Val67Met Uncertain significance Single submitter
All PSMD9 variants
Likely benign 5
- p.Arg195Ser Single submitter
- p.Gly125Asp Single submitter
- p.Ile50Val Single submitter
- p.Lys117Glu Single submitter
- p.Lys198Arg Single submitter
Uncertain significance 37
- p.Ala109Val Single submitter ⚠
- p.Ala148Val Single submitter ⚠
- p.Ala15Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg103Cys Single submitter ⚠
- p.Arg110Gln Single submitter ⚠
- p.Arg122Leu Single submitter ⚠
- p.Arg194His Single submitter
- p.Arg64Trp Single submitter
- p.Arg73Cys Single submitter
- p.Asn217Ser Single submitter ⚠
- p.Asn84His Single submitter ⚠
- p.Asp104Asn Single submitter ⚠
- p.Gln171Pro Single submitter ⚠
- p.Gly145Ser Single submitter ⚠
- p.Gly210Ala Single submitter ⚠
- p.Gly61Cys Single submitter
- p.His101Arg Single submitter ⚠
- p.His182Arg Single submitter
- p.Ile142Val Single submitter ⚠
- p.Ile50Thr Single submitter ⚠
- p.Leu26Val Single submitter ⚠
- p.Leu69Pro Single submitter ⚠
- p.Lys123Gln Single submitter ⚠
- p.Lys186Asn Single submitter ⚠
- p.Lys198Asn Single submitter ⚠
- p.Lys38Glu Single submitter ⚠
- p.Met112Lys Single submitter ⚠
- p.Met120Leu Single submitter ⚠
- p.Phe162Leu Single submitter ⚠
- p.Pro133Ser Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Ser13Leu Single submitter ⚠
- p.Ser143Asn Single submitter ⚠
- p.Thr191Ile Single submitter ⚠
- p.Thr191Pro Single submitter
- p.Val67Met Single submitter ⚠