PSME4 — 195 ClinVar variants
All ClinVar germline PSME4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 181 flagged for review →
6 Likely benign · 189 Uncertain significance
Full PSME4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 181
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 142
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSME4 p.Ala1137Asp Uncertain significance Single submitter
- PSME4 p.Ala120Thr Uncertain significance Single submitter
- PSME4 p.Ala1622Ser Uncertain significance Single submitter
- PSME4 p.Ala190Thr Uncertain significance Single submitter
- PSME4 p.Arg1131Cys Uncertain significance Single submitter
- PSME4 p.Arg1258Lys Uncertain significance Single submitter
- PSME4 p.Arg1340Gln Uncertain significance Single submitter
- PSME4 p.Arg135Lys Uncertain significance Single submitter
- PSME4 p.Arg359Gln Uncertain significance Single submitter
- PSME4 p.Arg370His Uncertain significance Single submitter
- PSME4 p.Arg43Gly Uncertain significance Single submitter
- PSME4 p.Arg526Ser Uncertain significance Single submitter
- PSME4 p.Arg861Gln Uncertain significance Single submitter
- PSME4 p.Arg861Leu Uncertain significance Single submitter
- PSME4 p.Asn1225Lys Uncertain significance Single submitter
- PSME4 p.Asn1415Ser Uncertain significance Single submitter
- PSME4 p.Asn1679Ser Uncertain significance Single submitter
- PSME4 p.Asn764His Uncertain significance Single submitter
- PSME4 p.Asn919Ser Uncertain significance Single submitter
- PSME4 p.Asp1093Ala Uncertain significance Single submitter
- PSME4 p.Asp1301Asn Uncertain significance Single submitter
- PSME4 p.Asp1354Glu Uncertain significance Single submitter
- PSME4 p.Asp137Val Uncertain significance Single submitter
- PSME4 p.Asp1546Ala Uncertain significance Single submitter
- PSME4 p.Asp1546Val Uncertain significance Single submitter
- PSME4 p.Asp1565Tyr Uncertain significance Single submitter
- PSME4 p.Asp1681Asn Uncertain significance Single submitter
- PSME4 p.Asp1794Asn Uncertain significance Single submitter
- PSME4 p.Asp236Gly Uncertain significance Single submitter
- PSME4 p.Asp273Asn Uncertain significance Single submitter
- PSME4 p.Asp518Asn Uncertain significance Single submitter
- PSME4 p.Asp518Gly Uncertain significance Single submitter
- PSME4 p.Cys798Tyr Uncertain significance Single submitter
- PSME4 p.Gln1021Arg Uncertain significance Single submitter
- PSME4 p.Gln1108His Uncertain significance Single submitter
- PSME4 p.Gln1133Glu Uncertain significance Single submitter
- PSME4 p.Gln1237His Uncertain significance Single submitter
- PSME4 p.Gln419His Uncertain significance Single submitter
- PSME4 p.Gln712Pro Uncertain significance Single submitter
- PSME4 p.Glu1105Gly Uncertain significance Single submitter
- PSME4 p.Glu1264Gln Uncertain significance Single submitter
- PSME4 p.Glu1396Asp Uncertain significance Single submitter
- PSME4 p.Glu1403Asp Uncertain significance Single submitter
- PSME4 p.Glu1539Ala Uncertain significance Single submitter
- PSME4 p.Glu1755Asp Uncertain significance Single submitter
- PSME4 p.Glu438Asp Uncertain significance Single submitter
- PSME4 p.Gly1153Ala Uncertain significance Single submitter
- PSME4 p.Gly240Asp Uncertain significance Single submitter
- PSME4 p.His909Asn Uncertain significance Single submitter
- PSME4 p.His930Leu Uncertain significance Single submitter
- PSME4 p.Ile1072Val Uncertain significance Single submitter
- PSME4 p.Ile1090Val Uncertain significance Single submitter
- PSME4 p.Ile1118Leu Uncertain significance Single submitter
- PSME4 p.Ile1118Met Uncertain significance Single submitter
- PSME4 p.Ile113Val Uncertain significance Single submitter
- PSME4 p.Ile1198Val Uncertain significance Single submitter
- PSME4 p.Ile1205Val Uncertain significance Single submitter
- PSME4 p.Ile1256Met Uncertain significance Single submitter
- PSME4 p.Ile1256Val Uncertain significance Single submitter
- PSME4 p.Ile1515Met Uncertain significance Single submitter
- PSME4 p.Ile1798Ser Uncertain significance Single submitter
- PSME4 p.Ile315Val Uncertain significance Single submitter
- PSME4 p.Ile400Val Uncertain significance Single submitter
- PSME4 p.Ile507Val Uncertain significance Single submitter
- PSME4 p.Ile55Val Uncertain significance Single submitter
- PSME4 p.Ile617Met Uncertain significance Single submitter
- PSME4 p.Ile617Val Uncertain significance Single submitter
- PSME4 p.Ile822Asn Uncertain significance Single submitter
- PSME4 p.Ile83Val Uncertain significance Single submitter
- PSME4 p.Ile99Ser Uncertain significance Single submitter
- PSME4 p.Leu1446Met Uncertain significance Single submitter
- PSME4 p.Leu1624Phe Uncertain significance Single submitter
- PSME4 p.Leu1830Phe Uncertain significance Single submitter
- PSME4 p.Leu325Pro Uncertain significance Single submitter
- PSME4 p.Leu415Val Uncertain significance Single submitter
- PSME4 p.Leu426Phe Uncertain significance Single submitter
- PSME4 p.Leu765Val Uncertain significance Single submitter
- PSME4 p.Leu792Val Uncertain significance Single submitter
- PSME4 p.Leu803Val Uncertain significance Single submitter
- PSME4 p.Leu821Phe Uncertain significance Single submitter
- PSME4 p.Leu839Phe Uncertain significance Single submitter
- PSME4 p.Leu846Phe Uncertain significance Single submitter
- PSME4 p.Leu855Val Uncertain significance Single submitter
- PSME4 p.Leu900Val Uncertain significance Single submitter
- PSME4 p.Lys1098Asn Uncertain significance Single submitter
- PSME4 p.Lys1220Arg Uncertain significance Single submitter
- PSME4 p.Lys1220Thr Uncertain significance Single submitter
- PSME4 p.Lys1260Glu Uncertain significance Single submitter
- PSME4 p.Lys1261Glu Uncertain significance Single submitter
- PSME4 p.Lys1400Thr Uncertain significance Single submitter
- PSME4 p.Lys1439Arg Uncertain significance Single submitter
- PSME4 p.Lys156Arg Uncertain significance Single submitter
- PSME4 p.Lys1758Gln Uncertain significance Single submitter
- PSME4 p.Lys599Arg Uncertain significance Single submitter
- PSME4 p.Lys802Asn Uncertain significance Single submitter
- PSME4 p.Lys850Glu Uncertain significance Single submitter
- PSME4 p.Lys874Thr Uncertain significance Single submitter
- PSME4 p.Lys908Arg Uncertain significance Single submitter
- PSME4 p.Met1065Val Uncertain significance Single submitter
- PSME4 p.Met115Leu Uncertain significance Single submitter
- PSME4 p.Met1668Thr Uncertain significance Single submitter
- PSME4 p.Met1800Val Uncertain significance Single submitter
- PSME4 p.Met843Ile Uncertain significance Single submitter
- PSME4 p.Met925Val Uncertain significance Single submitter
- PSME4 p.Phe235Cys Uncertain significance Single submitter
- PSME4 p.Pro1244Ser Uncertain significance Single submitter
- PSME4 p.Pro1520Ser Uncertain significance Single submitter
- PSME4 p.Pro274Leu Uncertain significance Single submitter
- PSME4 p.Pro376Thr Uncertain significance Single submitter
- PSME4 p.Pro639Ala Uncertain significance Single submitter
- PSME4 p.Pro759Ala Uncertain significance Single submitter
- PSME4 p.Pro759Thr Uncertain significance Single submitter
- PSME4 p.Ser1099Ala Uncertain significance Single submitter
- PSME4 p.Ser1121Ile Uncertain significance Single submitter
- PSME4 p.Ser1518Cys Uncertain significance Single submitter
- PSME4 p.Ser1590Ala Uncertain significance Single submitter
- PSME4 p.Ser1653Gly Uncertain significance Single submitter
- PSME4 p.Ser1692Arg Uncertain significance Single submitter
- PSME4 p.Ser727Cys Uncertain significance Single submitter
- PSME4 p.Ser889Thr Uncertain significance Single submitter
- PSME4 p.Thr1052Met Uncertain significance Single submitter
- PSME4 p.Thr1375Ile Uncertain significance Single submitter
- PSME4 p.Thr1667Ala Uncertain significance Single submitter
- PSME4 p.Thr595Ala Uncertain significance Single submitter
- PSME4 p.Thr715Asn Uncertain significance Single submitter
- PSME4 p.Thr728Ser Uncertain significance Single submitter
- PSME4 p.Thr734Ala Uncertain significance Single submitter
- PSME4 p.Trp75Arg Uncertain significance Single submitter
- PSME4 p.Trp763Gly Uncertain significance Single submitter
- PSME4 p.Tyr1511Cys Uncertain significance Single submitter
- PSME4 p.Val1073Ala Uncertain significance Single submitter
- PSME4 p.Val1101Leu Uncertain significance Single submitter
- PSME4 p.Val1190Ile Uncertain significance Single submitter
- PSME4 p.Val1289Met Uncertain significance Single submitter
- PSME4 p.Val1418Ile Uncertain significance Single submitter
- PSME4 p.Val1418Leu Uncertain significance Single submitter
- PSME4 p.Val149Ile Uncertain significance Single submitter
- PSME4 p.Val296Leu Uncertain significance Single submitter
- PSME4 p.Val647Ile Uncertain significance Single submitter
- PSME4 p.Val663Ile Uncertain significance Single submitter
- PSME4 p.Val686Ala Uncertain significance Single submitter
- PSME4 p.Val739Met Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- PSME4 p.Arg1176Ile Uncertain significance Single submitter
- PSME4 p.Arg1187Trp Uncertain significance Single submitter
- PSME4 p.Arg121Cys Uncertain significance Single submitter
- PSME4 p.Arg1341His Uncertain significance Single submitter
- PSME4 p.Arg1810Gln Uncertain significance Single submitter
- PSME4 p.Arg181Gln Uncertain significance Single submitter
- PSME4 p.Arg197Gln Uncertain significance Single submitter
- PSME4 p.Arg465Cys Uncertain significance Single submitter
- PSME4 p.Arg61Pro Uncertain significance Single submitter
- PSME4 p.Arg726Cys Uncertain significance Single submitter
- PSME4 p.Arg77Gly Uncertain significance Single submitter
- PSME4 p.Asn288Lys Uncertain significance Single submitter
- PSME4 p.Asp1077Glu Uncertain significance Single submitter
- PSME4 p.Asp1423Gly Uncertain significance Single submitter
- PSME4 p.Asp966Gly Uncertain significance Single submitter
- PSME4 p.Cys1030Tyr Uncertain significance Single submitter
- PSME4 p.Cys1769Tyr Uncertain significance Single submitter
- PSME4 p.Cys631Tyr Uncertain significance Single submitter
- PSME4 p.Glu1134Gly Uncertain significance Single submitter
- PSME4 p.Glu1566Gly Uncertain significance Single submitter
- PSME4 p.Glu252Asp Uncertain significance Single submitter
- PSME4 p.Gly230Ser Uncertain significance Single submitter
- PSME4 p.Gly995Glu Uncertain significance Single submitter
- PSME4 p.His310Arg Uncertain significance Single submitter
- PSME4 p.Leu193Ile Uncertain significance Single submitter
- PSME4 p.Leu289Val Uncertain significance Single submitter
- PSME4 p.Leu368Trp Uncertain significance Single submitter
- PSME4 p.Lys352Asn Uncertain significance Single submitter
- PSME4 p.Lys89Thr Uncertain significance Single submitter
- PSME4 p.Met115Ile Uncertain significance Single submitter
- PSME4 p.Met192Ile Uncertain significance Single submitter
- PSME4 p.Ser1062Asn Uncertain significance Single submitter
- PSME4 p.Ser860Cys Uncertain significance Single submitter
- PSME4 p.Thr589Ser Uncertain significance Single submitter
- PSME4 p.Thr595Pro Uncertain significance Single submitter
- PSME4 p.Trp1274Cys Uncertain significance Single submitter
- PSME4 p.Tyr154His Uncertain significance Single submitter
- PSME4 p.Val1497Phe Uncertain significance Single submitter
- PSME4 p.Val1508Leu Uncertain significance Single submitter
All PSME4 variants
Likely benign 6
- p.Asp271= Single submitter
- p.Asp800= Single submitter
- p.Ile172= Single submitter
- p.Pro830= Single submitter
- p.Val793Ile Single submitter
- p.Cys1427= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 189
- p.Ala1137Asp Single submitter ⚠
- p.Ala120Thr Single submitter ⚠
- p.Ala1622Ser Single submitter ⚠
- p.Ala190Thr Single submitter ⚠
- p.Arg1131Cys Single submitter ⚠
- p.Arg1176Ile Single submitter ⚠
- p.Arg1187Trp Single submitter ⚠
- p.Arg121Cys Single submitter ⚠
- p.Arg1258Lys Single submitter ⚠
- p.Arg1340Gln Single submitter ⚠
- p.Arg1341Cys Single submitter
- p.Arg1341His Single submitter ⚠
- p.Arg135Lys Single submitter ⚠
- p.Arg1810Gln Single submitter ⚠
- p.Arg181Gln Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Arg359Gln Single submitter ⚠
- p.Arg370His Single submitter ⚠
- p.Arg43Gly Single submitter ⚠
- p.Arg465Cys Single submitter ⚠
- p.Arg526Ser Single submitter ⚠
- p.Arg61Pro Single submitter ⚠
- p.Arg726Cys Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Arg861Gln Single submitter ⚠
- p.Arg861Leu Single submitter ⚠
- p.Asn1225Lys Single submitter ⚠
- p.Asn1415Ser Single submitter ⚠
- p.Asn1679Ser Single submitter ⚠
- p.Asn288Lys Single submitter ⚠
- p.Asn764His Single submitter ⚠
- p.Asn919Ser Single submitter ⚠
- p.Asp1077Glu Single submitter ⚠
- p.Asp1093Ala Single submitter ⚠
- p.Asp1301Asn Single submitter ⚠
- p.Asp1354Glu Single submitter ⚠
- p.Asp137Val Single submitter ⚠
- p.Asp1423Gly Single submitter ⚠
- p.Asp1546Ala Single submitter ⚠
- p.Asp1546Val Single submitter ⚠
- p.Asp1565Tyr Single submitter ⚠
- p.Asp1681Asn Single submitter ⚠
- p.Asp1794Asn Single submitter ⚠
- p.Asp236Gly Single submitter ⚠
- p.Asp273Asn Single submitter ⚠
- p.Asp518Asn Single submitter ⚠
- p.Asp518Gly Single submitter ⚠
- p.Asp966Gly Single submitter ⚠
- p.Cys1030Tyr Single submitter ⚠
- p.Cys1769Tyr Single submitter ⚠
- p.Cys631Tyr Single submitter ⚠
- p.Cys798Tyr Single submitter ⚠
- p.Gln1021Arg Single submitter ⚠
- p.Gln1108His Single submitter ⚠
- p.Gln1133Glu Single submitter ⚠
- p.Gln1237His Single submitter ⚠
- p.Gln419His Single submitter ⚠
- p.Gln712Pro Single submitter ⚠
- p.Glu1105Gly Single submitter ⚠
- p.Glu1134Gly Single submitter ⚠
- p.Glu1264Gln Single submitter ⚠
- p.Glu1396Asp Single submitter ⚠
- p.Glu1403Asp Single submitter ⚠
- p.Glu1539Ala Single submitter ⚠
- p.Glu1566Gly Single submitter ⚠
- p.Glu1755Asp Single submitter ⚠
- p.Glu252Asp Single submitter ⚠
- p.Glu438Asp Single submitter ⚠
- p.Gly1153Ala Single submitter ⚠
- p.Gly230Ser Single submitter ⚠
- p.Gly240Asp Single submitter ⚠
- p.Gly995Glu Single submitter ⚠
- p.His310Arg Single submitter ⚠
- p.His909Asn Single submitter ⚠
- p.His930Leu Single submitter ⚠
- p.Ile1072Val Single submitter ⚠
- p.Ile1090Val Single submitter ⚠
- p.Ile1118Leu Single submitter ⚠
- p.Ile1118Met Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile1198Val Single submitter ⚠
- p.Ile1205Val Single submitter ⚠
- p.Ile1256Met Single submitter ⚠
- p.Ile1256Val Single submitter ⚠
- p.Ile1515Met Single submitter ⚠
- p.Ile1798Ser Single submitter ⚠
- p.Ile315Val Single submitter ⚠
- p.Ile400Val Single submitter ⚠
- p.Ile507Val Single submitter ⚠
- p.Ile55Val Single submitter ⚠
- p.Ile617Met Single submitter ⚠
- p.Ile617Val Single submitter ⚠
- p.Ile822Asn Single submitter ⚠
- p.Ile83Val Single submitter ⚠
- p.Ile893Thr Single submitter
- p.Ile99Ser Single submitter ⚠
- p.Leu1446Met Single submitter ⚠
- p.Leu1624Phe Single submitter ⚠
- p.Leu1756Phe Single submitter
- p.Leu1830Phe Single submitter ⚠
- p.Leu193Ile Single submitter ⚠
- p.Leu289Val Single submitter ⚠
- p.Leu325Pro Single submitter ⚠
- p.Leu368Trp Single submitter ⚠
- p.Leu415Val Single submitter ⚠
- p.Leu426Phe Single submitter ⚠
- p.Leu765Val Single submitter ⚠
- p.Leu792Val Single submitter ⚠
- p.Leu803Val Single submitter ⚠
- p.Leu821Phe Single submitter ⚠
- p.Leu839Phe Single submitter ⚠
- p.Leu846Phe Single submitter ⚠
- p.Leu855Val Single submitter ⚠
- p.Leu900Val Single submitter ⚠
- p.Lys1098Asn Single submitter ⚠
- p.Lys1220Arg Single submitter ⚠
- p.Lys1220Thr Single submitter ⚠
- p.Lys1260Glu Single submitter ⚠
- p.Lys1261Glu Single submitter ⚠
- p.Lys1400Thr Single submitter ⚠
- p.Lys1439Arg Single submitter ⚠
- p.Lys156Arg Single submitter ⚠
- p.Lys1758Gln Single submitter ⚠
- p.Lys352Asn Single submitter ⚠
- p.Lys599Arg Single submitter ⚠
- p.Lys802Asn Single submitter ⚠
- p.Lys850Glu Single submitter ⚠
- p.Lys874Thr Single submitter ⚠
- p.Lys89Thr Single submitter ⚠
- p.Lys908Arg Single submitter ⚠
- p.Met1065Val Single submitter ⚠
- p.Met115Ile Single submitter ⚠
- p.Met115Leu Single submitter ⚠
- p.Met1668Thr Single submitter ⚠
- p.Met1800Val Single submitter ⚠
- p.Met192Ile Single submitter ⚠
- p.Met843Ile Single submitter ⚠
- p.Met925Val Single submitter ⚠
- p.Phe1676Cys Single submitter
- p.Phe235Cys Single submitter ⚠
- p.Pro1226Leu Single submitter
- p.Pro1244Ser Single submitter ⚠
- p.Pro1520Ser Single submitter ⚠
- p.Pro274Leu Single submitter ⚠
- p.Pro376Thr Single submitter ⚠
- p.Pro434Leu Single submitter
- p.Pro639Ala Single submitter ⚠
- p.Pro759Ala Single submitter ⚠
- p.Pro759Thr Single submitter ⚠
- p.Ser1062Asn Single submitter ⚠
- p.Ser1099Ala Single submitter ⚠
- p.Ser1121Ile Single submitter ⚠
- p.Ser1518Cys Single submitter ⚠
- p.Ser1590Ala Single submitter ⚠
- p.Ser1653Gly Single submitter ⚠
- p.Ser1692Arg Single submitter ⚠
- p.Ser727Cys Single submitter ⚠
- p.Ser860Cys Single submitter ⚠
- p.Ser889Thr Single submitter ⚠
- p.Thr1052Met Single submitter ⚠
- p.Thr1375Ile Single submitter ⚠
- p.Thr1495Ile Single submitter
- p.Thr1667Ala Single submitter ⚠
- p.Thr589Ser Single submitter ⚠
- p.Thr595Ala Single submitter ⚠
- p.Thr595Pro Single submitter ⚠
- p.Thr715Asn Single submitter ⚠
- p.Thr728Ser Single submitter ⚠
- p.Thr734Ala Single submitter ⚠
- p.Trp1274Cys Single submitter ⚠
- p.Trp75Arg Single submitter ⚠
- p.Trp763Gly Single submitter ⚠
- p.Tyr1277His Single submitter
- p.Tyr1511Cys Single submitter ⚠
- p.Tyr154His Single submitter ⚠
- p.Val1073Ala Single submitter ⚠
- p.Val1101Leu Single submitter ⚠
- p.Val1190Ile Single submitter ⚠
- p.Val1289Met Single submitter ⚠
- p.Val1418Ile Single submitter ⚠
- p.Val1418Leu Single submitter ⚠
- p.Val1497Phe Single submitter ⚠
- p.Val149Ile Single submitter ⚠
- p.Val1508Leu Single submitter ⚠
- p.Val296Leu Single submitter ⚠
- p.Val647Ile Single submitter ⚠
- p.Val663Ile Single submitter ⚠
- p.Val686Ala Single submitter ⚠
- p.Val739Met Single submitter ⚠