PSMG3 — 11 ClinVar variants
All ClinVar germline PSMG3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Likely benign · 10 Uncertain significance
Full PSMG3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSMG3 p.Ala98Ser Uncertain significance Single submitter
- PSMG3 p.Asp3Tyr Uncertain significance Single submitter
- PSMG3 p.Ser30Asn Uncertain significance Single submitter
- PSMG3 p.Thr4Met Uncertain significance Single submitter
- PSMG3 p.Val19Ile Uncertain significance Single submitter
- PSMG3 p.Val46Ile Uncertain significance Single submitter
- PSMG3 p.Val53Leu Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All PSMG3 variants
Likely benign 1
- p.Pro5= Single submitter
Uncertain significance 10
- p.Ala98Ser Single submitter ⚠
- p.Asp3Tyr Single submitter ⚠
- p.His31Pro Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Ser30Asn Single submitter ⚠
- p.Thr4Met Single submitter ⚠
- p.Val19Ile Single submitter ⚠
- p.Val46Ile Single submitter ⚠
- p.Val53Leu Single submitter ⚠