PSPC1 — 60 ClinVar variants
All ClinVar germline PSPC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
60 Uncertain significance
Full PSPC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PSPC1 p.Ala407Gly Uncertain significance Single submitter
- PSPC1 p.Ala411Ser Uncertain significance Single submitter
- PSPC1 p.Ala42Asp Uncertain significance Single submitter
- PSPC1 p.Arg20Leu Uncertain significance Single submitter
- PSPC1 p.Arg228Leu Uncertain significance Single submitter
- PSPC1 p.Arg264Cys Uncertain significance Single submitter
- PSPC1 p.Arg327Cys Uncertain significance Single submitter
- PSPC1 p.Arg333Cys Uncertain significance Single submitter
- PSPC1 p.Arg333Leu Uncertain significance Single submitter
- PSPC1 p.Asn450Asp Uncertain significance Single submitter
- PSPC1 p.Asn518Ser Uncertain significance Single submitter
- PSPC1 p.Asp116Glu Uncertain significance Single submitter
- PSPC1 p.Asp58Asn Uncertain significance Single submitter
- PSPC1 p.Gln328Leu Uncertain significance Single submitter
- PSPC1 p.Gln369Glu Uncertain significance Single submitter
- PSPC1 p.Gln474Arg Uncertain significance Single submitter
- PSPC1 p.Glu136Gly Uncertain significance Single submitter
- PSPC1 p.Glu170Ala Uncertain significance Single submitter
- PSPC1 p.Gly193Ser Uncertain significance Single submitter
- PSPC1 p.Gly414Ser Uncertain significance Single submitter
- PSPC1 p.Gly476Ser Uncertain significance Single submitter
- PSPC1 p.Gly512Asp Uncertain significance Single submitter
- PSPC1 p.Lys68Arg Uncertain significance Single submitter
- PSPC1 p.Met393Val Uncertain significance Single submitter
- PSPC1 p.Met451Val Uncertain significance Single submitter
- PSPC1 p.Met455Val Uncertain significance Single submitter
- PSPC1 p.Met475Val Uncertain significance Single submitter
- PSPC1 p.Pro31Thr Uncertain significance Single submitter
- PSPC1 p.Pro381Ala Uncertain significance Single submitter
- PSPC1 p.Pro436Thr Uncertain significance Single submitter
- PSPC1 p.Pro471Leu Uncertain significance Single submitter
- PSPC1 p.Pro488His Uncertain significance Single submitter
- PSPC1 p.Pro57Leu Uncertain significance Single submitter
- PSPC1 p.Ser29Arg Uncertain significance Single submitter
- PSPC1 p.Ser473Thr Uncertain significance Single submitter
- PSPC1 p.Thr159Ala Uncertain significance Single submitter
- PSPC1 p.Thr453Ile Uncertain significance Single submitter
- PSPC1 p.Thr487Asn Uncertain significance Single submitter
- PSPC1 p.Val26Met Uncertain significance Single submitter
- PSPC1 p.Val498Met Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- PSPC1 p.Ala156Thr Uncertain significance Single submitter
- PSPC1 p.Ala281Gly Uncertain significance Single submitter
- PSPC1 p.Ala300Val Uncertain significance Single submitter
- PSPC1 p.Arg228His Uncertain significance Single submitter
- PSPC1 p.Arg357Gln Uncertain significance Single submitter
- PSPC1 p.Arg521Cys Uncertain significance Single submitter
- PSPC1 p.Asn114Ser Uncertain significance Single submitter
- PSPC1 p.Asn403Lys Uncertain significance Single submitter
- PSPC1 p.Asn428Lys Uncertain significance Single submitter
- PSPC1 p.Asp283Glu Uncertain significance Single submitter
- PSPC1 p.Gln340His Uncertain significance Single submitter
- PSPC1 p.Glu354Ala Uncertain significance Single submitter
- PSPC1 p.Gly405Arg Uncertain significance Single submitter
- PSPC1 p.Gly423Arg Uncertain significance Single submitter
- PSPC1 p.Gly444Glu Uncertain significance Single submitter
- PSPC1 p.His352Arg Uncertain significance Single submitter
- PSPC1 p.Met285Val Uncertain significance Single submitter
- PSPC1 p.Phe221Leu Uncertain significance Single submitter
- PSPC1 p.Thr153Ala Uncertain significance Single submitter
- PSPC1 p.Val182Leu Uncertain significance Single submitter
All PSPC1 variants
Uncertain significance 60
- p.Ala156Thr Single submitter ⚠
- p.Ala281Gly Single submitter ⚠
- p.Ala300Val Single submitter ⚠
- p.Ala407Gly Single submitter ⚠
- p.Ala411Ser Single submitter ⚠
- p.Ala42Asp Single submitter ⚠
- p.Arg20Leu Single submitter ⚠
- p.Arg228His Single submitter ⚠
- p.Arg228Leu Single submitter ⚠
- p.Arg264Cys Single submitter ⚠
- p.Arg327Cys Single submitter ⚠
- p.Arg333Cys Single submitter ⚠
- p.Arg333Leu Single submitter ⚠
- p.Arg357Gln Single submitter ⚠
- p.Arg521Cys Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn403Lys Single submitter ⚠
- p.Asn428Lys Single submitter ⚠
- p.Asn450Asp Single submitter ⚠
- p.Asn518Ser Single submitter ⚠
- p.Asp116Glu Single submitter ⚠
- p.Asp283Glu Single submitter ⚠
- p.Asp58Asn Single submitter ⚠
- p.Gln328Leu Single submitter ⚠
- p.Gln340His Single submitter ⚠
- p.Gln369Glu Single submitter ⚠
- p.Gln474Arg Single submitter ⚠
- p.Glu136Gly Single submitter ⚠
- p.Glu170Ala Single submitter ⚠
- p.Glu354Ala Single submitter ⚠
- p.Gly193Ser Single submitter ⚠
- p.Gly405Arg Single submitter ⚠
- p.Gly414Ser Single submitter ⚠
- p.Gly423Arg Single submitter ⚠
- p.Gly444Glu Single submitter ⚠
- p.Gly476Ser Single submitter ⚠
- p.Gly512Asp Single submitter ⚠
- p.His352Arg Single submitter ⚠
- p.Lys68Arg Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Met393Val Single submitter ⚠
- p.Met451Val Single submitter ⚠
- p.Met455Val Single submitter ⚠
- p.Met475Val Single submitter ⚠
- p.Phe221Leu Single submitter ⚠
- p.Pro31Thr Single submitter ⚠
- p.Pro381Ala Single submitter ⚠
- p.Pro436Thr Single submitter ⚠
- p.Pro471Leu Single submitter ⚠
- p.Pro488His Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Ser29Arg Single submitter ⚠
- p.Ser473Thr Single submitter ⚠
- p.Thr153Ala Single submitter ⚠
- p.Thr159Ala Single submitter ⚠
- p.Thr453Ile Single submitter ⚠
- p.Thr487Asn Single submitter ⚠
- p.Val182Leu Single submitter ⚠
- p.Val26Met Single submitter ⚠
- p.Val498Met Single submitter ⚠