PTGDR2 — 63 ClinVar variants
All ClinVar germline PTGDR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
1 Benign · 3 Likely benign · 59 Uncertain significance
Full PTGDR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTGDR2 p.Ala147Thr Uncertain significance Single submitter
- PTGDR2 p.Ala227Gly Uncertain significance Single submitter
- PTGDR2 p.Ala228Ser Uncertain significance Single submitter
- PTGDR2 p.Ala389Gly Uncertain significance Single submitter
- PTGDR2 p.Ala42Ser Uncertain significance Single submitter
- PTGDR2 p.Arg135Gln Uncertain significance Single submitter
- PTGDR2 p.Arg135Pro Uncertain significance Single submitter
- PTGDR2 p.Arg143Cys Uncertain significance Single submitter
- PTGDR2 p.Arg232Leu Uncertain significance Single submitter
- PTGDR2 p.Arg240Gln Uncertain significance Single submitter
- PTGDR2 p.Arg271Gln Uncertain significance Single submitter
- PTGDR2 p.Arg284His Uncertain significance Single submitter
- PTGDR2 p.Arg316Gln Uncertain significance Single submitter
- PTGDR2 p.Arg317Cys Uncertain significance Single submitter
- PTGDR2 p.Arg359Leu Uncertain significance Single submitter
- PTGDR2 p.Asn275Ser Uncertain significance Single submitter
- PTGDR2 p.Asp329Glu Uncertain significance Single submitter
- PTGDR2 p.Cys182Arg Uncertain significance Single submitter
- PTGDR2 p.Cys308Gly Uncertain significance Single submitter
- PTGDR2 p.Glu332Gln Uncertain significance Single submitter
- PTGDR2 p.Glu362Asp Uncertain significance Single submitter
- PTGDR2 p.Gly334Asp Uncertain significance Single submitter
- PTGDR2 p.Gly371Arg Uncertain significance Single submitter
- PTGDR2 p.Leu122Pro Uncertain significance Single submitter
- PTGDR2 p.Leu131Pro Uncertain significance Single submitter
- PTGDR2 p.Leu187Val Uncertain significance Single submitter
- PTGDR2 p.Leu327Met Uncertain significance Single submitter
- PTGDR2 p.Lys150Gln Uncertain significance Single submitter
- PTGDR2 p.Met181Val Uncertain significance Single submitter
- PTGDR2 p.Pro280Leu Uncertain significance Single submitter
- PTGDR2 p.Pro301Leu Uncertain significance Single submitter
- PTGDR2 p.Pro366Ser Uncertain significance Single submitter
- PTGDR2 p.Pro381Gln Uncertain significance Single submitter
- PTGDR2 p.Ser346Thr Uncertain significance Single submitter
- PTGDR2 p.Ser352Pro Uncertain significance Single submitter
- PTGDR2 p.Ser394Leu Uncertain significance Single submitter
- PTGDR2 p.Thr144Ser Uncertain significance Single submitter
- PTGDR2 p.Val208Ile Uncertain significance Single submitter
- PTGDR2 p.Val229Met Uncertain significance Single submitter
- PTGDR2 p.Val298Ala Uncertain significance Single submitter
- PTGDR2 p.Val322Ala Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- PTGDR2 p.Arg179Ser Uncertain significance Single submitter
- PTGDR2 p.Arg19Pro Uncertain significance Single submitter
- PTGDR2 p.Asp32Gly Uncertain significance Single submitter
- PTGDR2 p.Cys152Gly Uncertain significance Single submitter
- PTGDR2 p.Cys308Arg Uncertain significance Single submitter
- PTGDR2 p.His263Gln Uncertain significance Single submitter
- PTGDR2 p.Leu14Pro Uncertain significance Single submitter
- PTGDR2 p.Leu247Pro Uncertain significance Single submitter
- PTGDR2 p.Lys210Glu Uncertain significance Single submitter
- PTGDR2 p.Phe255Leu Uncertain significance Single submitter
- PTGDR2 p.Phe55Leu Uncertain significance Single submitter
- PTGDR2 p.Ser225Asn Uncertain significance Single submitter
- PTGDR2 p.Tyr183Ser Uncertain significance Single submitter
- PTGDR2 p.Val133Met Uncertain significance Single submitter
- PTGDR2 p.Val145Gly Uncertain significance Single submitter
- PTGDR2 p.Val56Met Uncertain significance Single submitter
All PTGDR2 variants
Benign 1
- p.Lys150fs Single submitter
Likely benign 3
- p.Leu281Phe Single submitter
- p.Ser81Thr Single submitter
- p.Val52Leu Single submitter
Uncertain significance 59
- p.Ala147Thr Single submitter ⚠
- p.Ala148Val Single submitter
- p.Ala227Gly Single submitter ⚠
- p.Ala228Ser Single submitter ⚠
- p.Ala389Gly Single submitter ⚠
- p.Ala42Ser Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg135Pro Single submitter ⚠
- p.Arg143Cys Single submitter ⚠
- p.Arg179Ser Single submitter ⚠
- p.Arg19Pro Single submitter ⚠
- p.Arg232Leu Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg317Cys Single submitter ⚠
- p.Arg359Leu Single submitter ⚠
- p.Asn275Ser Single submitter ⚠
- p.Asp329Glu Single submitter ⚠
- p.Asp32Gly Single submitter ⚠
- p.Cys130Ser Single submitter
- p.Cys152Gly Single submitter ⚠
- p.Cys182Arg Single submitter ⚠
- p.Cys308Arg Single submitter ⚠
- p.Cys308Gly Single submitter ⚠
- p.Glu332Gln Single submitter ⚠
- p.Glu362Asp Single submitter ⚠
- p.Gly334Asp Single submitter ⚠
- p.Gly371Arg Single submitter ⚠
- p.His263Gln Single submitter ⚠
- p.Leu122Pro Single submitter ⚠
- p.Leu131Pro Single submitter ⚠
- p.Leu14Pro Single submitter ⚠
- p.Leu187Val Single submitter ⚠
- p.Leu247Pro Single submitter ⚠
- p.Leu327Met Single submitter ⚠
- p.Lys150Gln Single submitter ⚠
- p.Lys210Glu Single submitter ⚠
- p.Met181Val Single submitter ⚠
- p.Phe255Leu Single submitter ⚠
- p.Phe55Leu Single submitter ⚠
- p.Pro280Leu Single submitter ⚠
- p.Pro301Leu Single submitter ⚠
- p.Pro366Ser Single submitter ⚠
- p.Pro381Gln Single submitter ⚠
- p.Ser225Asn Single submitter ⚠
- p.Ser346Thr Single submitter ⚠
- p.Ser352Pro Single submitter ⚠
- p.Ser394Leu Single submitter ⚠
- p.Thr144Ser Single submitter ⚠
- p.Tyr183Ser Single submitter ⚠
- p.Val133Met Single submitter ⚠
- p.Val145Gly Single submitter ⚠
- p.Val208Ile Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val298Ala Single submitter ⚠
- p.Val322Ala Single submitter ⚠
- p.Val56Met Single submitter ⚠