PTGER1 — 78 ClinVar variants
All ClinVar germline PTGER1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
5 Likely benign · 73 Uncertain significance
Full PTGER1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTGER1 p.Ala147Val Uncertain significance Single submitter
- PTGER1 p.Ala154Thr Uncertain significance Single submitter
- PTGER1 p.Ala160Val Uncertain significance Single submitter
- PTGER1 p.Ala165Asp Uncertain significance Single submitter
- PTGER1 p.Ala19Thr Uncertain significance Single submitter
- PTGER1 p.Ala19Val Uncertain significance Single submitter
- PTGER1 p.Ala204Thr Uncertain significance Single submitter
- PTGER1 p.Ala34Gly Uncertain significance Single submitter
- PTGER1 p.Ala377Thr Uncertain significance Single submitter
- PTGER1 p.Ala385Thr Uncertain significance Single submitter
- PTGER1 p.Arg141Gln Uncertain significance Single submitter
- PTGER1 p.Arg148Trp Uncertain significance Single submitter
- PTGER1 p.Arg155Leu Uncertain significance Single submitter
- PTGER1 p.Arg178Leu Uncertain significance Single submitter
- PTGER1 p.Arg237Gly Uncertain significance Single submitter
- PTGER1 p.Arg239Gln Uncertain significance Single submitter
- PTGER1 p.Arg331Pro Uncertain significance Single submitter
- PTGER1 p.Arg360His Uncertain significance Single submitter
- PTGER1 p.Arg369Lys Uncertain significance Single submitter
- PTGER1 p.Arg63Leu Uncertain significance Single submitter
- PTGER1 p.Asn343Asp Uncertain significance Single submitter
- PTGER1 p.Asp347Ala Uncertain significance Single submitter
- PTGER1 p.Cys309Tyr Uncertain significance Single submitter
- PTGER1 p.Gly102Arg Uncertain significance Single submitter
- PTGER1 p.Gly108Arg Uncertain significance Single submitter
- PTGER1 p.Gly130Ser Uncertain significance Single submitter
- PTGER1 p.Gly177Asp Uncertain significance Single submitter
- PTGER1 p.Gly197Cys Uncertain significance Single submitter
- PTGER1 p.Gly371Ala Uncertain significance Single submitter
- PTGER1 p.Gly62Cys Uncertain significance Single submitter
- PTGER1 p.Ile308Val Uncertain significance Single submitter
- PTGER1 p.Leu203Phe Uncertain significance Single submitter
- PTGER1 p.Leu224Pro Uncertain significance Single submitter
- PTGER1 p.Leu353Pro Uncertain significance Single submitter
- PTGER1 p.Phe189Ile Uncertain significance Single submitter
- PTGER1 p.Pro105Leu Uncertain significance Single submitter
- PTGER1 p.Pro172Arg Uncertain significance Single submitter
- PTGER1 p.Pro194Thr Uncertain significance Single submitter
- PTGER1 p.Pro242His Uncertain significance Single submitter
- PTGER1 p.Pro242Leu Uncertain significance Single submitter
- PTGER1 p.Pro243Leu Uncertain significance Single submitter
- PTGER1 p.Pro243Thr Uncertain significance Single submitter
- PTGER1 p.Pro368Arg Uncertain significance Single submitter
- PTGER1 p.Pro383Leu Uncertain significance Single submitter
- PTGER1 p.Pro6Ser Uncertain significance Single submitter
- PTGER1 p.Ser238Tyr Uncertain significance Single submitter
- PTGER1 p.Ser264Leu Uncertain significance Single submitter
- PTGER1 p.Ser265Ala Uncertain significance Single submitter
- PTGER1 p.Ser284Leu Uncertain significance Single submitter
- PTGER1 p.Ser389Gly Uncertain significance Single submitter
- PTGER1 p.Ser42Ala Uncertain significance Single submitter
- PTGER1 p.Ser79Gly Uncertain significance Single submitter
- PTGER1 p.Thr16Ala Uncertain significance Single submitter
- PTGER1 p.Trp234Arg Uncertain significance Single submitter
- PTGER1 p.Val133Ala Uncertain significance Single submitter
- PTGER1 p.Val151Gly Uncertain significance Single submitter
- PTGER1 p.Val23Gly Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- PTGER1 p.Ala58Glu Uncertain significance Single submitter
- PTGER1 p.Arg153Leu Uncertain significance Single submitter
- PTGER1 p.Asn8Tyr Uncertain significance Single submitter
- PTGER1 p.Gly322Arg Uncertain significance Single submitter
- PTGER1 p.Gly92Ser Uncertain significance Single submitter
- PTGER1 p.His88Gln Uncertain significance Single submitter
- PTGER1 p.Ile352Thr Uncertain significance Single submitter
- PTGER1 p.Leu173Met Uncertain significance Single submitter
- PTGER1 p.Leu80Met Uncertain significance Single submitter
- PTGER1 p.Pro105Arg Uncertain significance Single submitter
- PTGER1 p.Pro184Ser Uncertain significance Single submitter
- PTGER1 p.Ser225Arg Uncertain significance Single submitter
- PTGER1 p.Ser390Trp Uncertain significance Single submitter
- PTGER1 p.Thr83Asn Uncertain significance Single submitter
- PTGER1 p.Val77Met Uncertain significance Single submitter
All PTGER1 variants
Likely benign 5
- p.Ala318Val Single submitter
- p.Pro91= Single submitter
- p.Thr100Ala Single submitter
- p.Trp22Gly Single submitter
- p.Val161Leu Single submitter
Uncertain significance 73
- p.Ala147Val Single submitter ⚠
- p.Ala154Thr Single submitter ⚠
- p.Ala160Val Single submitter ⚠
- p.Ala165Asp Single submitter ⚠
- p.Ala19Thr Single submitter ⚠
- p.Ala19Val Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala34Gly Single submitter ⚠
- p.Ala377Thr Single submitter ⚠
- p.Ala385Thr Single submitter ⚠
- p.Ala58Glu Single submitter ⚠
- p.Ala60fs Single submitter
- p.Arg141Gln Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg153Leu Single submitter ⚠
- p.Arg155Leu Single submitter ⚠
- p.Arg178Leu Single submitter ⚠
- p.Arg237Gly Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg331Pro Single submitter ⚠
- p.Arg360His Single submitter ⚠
- p.Arg369Lys Single submitter ⚠
- p.Arg63Leu Single submitter ⚠
- p.Asn343Asp Single submitter ⚠
- p.Asn8Tyr Single submitter ⚠
- p.Asp347Ala Single submitter ⚠
- p.Cys309Tyr Single submitter ⚠
- p.Gly102Arg Single submitter ⚠
- p.Gly108Arg Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly177Asp Single submitter ⚠
- p.Gly197Cys Single submitter ⚠
- p.Gly322Arg Single submitter ⚠
- p.Gly371Ala Single submitter ⚠
- p.Gly62Cys Single submitter ⚠
- p.Gly92Ser Single submitter ⚠
- p.His88Gln Single submitter ⚠
- p.Ile308Val Single submitter ⚠
- p.Ile352Thr Single submitter ⚠
- p.Leu173Met Single submitter ⚠
- p.Leu203Phe Single submitter ⚠
- p.Leu224Pro Single submitter ⚠
- p.Leu353Pro Single submitter ⚠
- p.Leu80Met Single submitter ⚠
- p.Phe189Ile Single submitter ⚠
- p.Pro105Arg Single submitter ⚠
- p.Pro105Leu Single submitter ⚠
- p.Pro172Arg Single submitter ⚠
- p.Pro184Ser Single submitter ⚠
- p.Pro194Thr Single submitter ⚠
- p.Pro242His Single submitter ⚠
- p.Pro242Leu Single submitter ⚠
- p.Pro243Leu Single submitter ⚠
- p.Pro243Thr Single submitter ⚠
- p.Pro368Arg Single submitter ⚠
- p.Pro383Leu Single submitter ⚠
- p.Pro6Ser Single submitter ⚠
- p.Ser225Arg Single submitter ⚠
- p.Ser238Tyr Single submitter ⚠
- p.Ser264Leu Single submitter ⚠
- p.Ser265Ala Single submitter ⚠
- p.Ser284Leu Single submitter ⚠
- p.Ser389Gly Single submitter ⚠
- p.Ser390Trp Single submitter ⚠
- p.Ser42Ala Single submitter ⚠
- p.Ser79Gly Single submitter ⚠
- p.Thr16Ala Single submitter ⚠
- p.Thr83Asn Single submitter ⚠
- p.Trp234Arg Single submitter ⚠
- p.Val133Ala Single submitter ⚠
- p.Val151Gly Single submitter ⚠
- p.Val23Gly Single submitter ⚠
- p.Val77Met Single submitter ⚠