PTGER2 — 40 ClinVar variants
All ClinVar germline PTGER2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
1 Benign/Likely benign · 3 Likely benign · 36 Uncertain significance
Full PTGER2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTGER2 p.Arg224Cys Uncertain significance Single submitter
- PTGER2 p.Arg242Trp Uncertain significance Single submitter
- PTGER2 p.Arg249Ser Uncertain significance Single submitter
- PTGER2 p.Arg333Gln Uncertain significance Single submitter
- PTGER2 p.Arg51Leu Uncertain significance Single submitter
- PTGER2 p.Arg60His Uncertain significance Single submitter
- PTGER2 p.Asp357Glu Uncertain significance Single submitter
- PTGER2 p.Asp78Glu Uncertain significance Single submitter
- PTGER2 p.Asp78His Uncertain significance Single submitter
- PTGER2 p.Glu105Lys Uncertain significance Single submitter
- PTGER2 p.Gly22Asp Uncertain significance Single submitter
- PTGER2 p.Gly243Val Uncertain significance Single submitter
- PTGER2 p.Gly246Trp Uncertain significance Single submitter
- PTGER2 p.Gly2Asp Uncertain significance Single submitter
- PTGER2 p.Ile264Phe Uncertain significance Single submitter
- PTGER2 p.Ile306Val Uncertain significance Single submitter
- PTGER2 p.Met116Arg Uncertain significance Single submitter
- PTGER2 p.Met116Val Uncertain significance Single submitter
- PTGER2 p.Met256Arg Uncertain significance Single submitter
- PTGER2 p.Met286Val Uncertain significance Single submitter
- PTGER2 p.Pro312Leu Uncertain significance Single submitter
- PTGER2 p.Pro87Leu Uncertain significance Single submitter
- PTGER2 p.Ser335Leu Uncertain significance Single submitter
- PTGER2 p.Ser33Leu Uncertain significance Single submitter
- PTGER2 p.Trp18Arg Uncertain significance Single submitter
- PTGER2 p.Val69Met Uncertain significance Single submitter
- PTGER2 p.Val71Gly Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- PTGER2 p.Ala42Val Uncertain significance Single submitter
- PTGER2 p.Glu73Lys Uncertain significance Single submitter
- PTGER2 p.Ile264Thr Uncertain significance Single submitter
- PTGER2 p.Met269Val Uncertain significance Single submitter
- PTGER2 p.Pro104Leu Uncertain significance Single submitter
- PTGER2 p.Ser28Gly Uncertain significance Single submitter
- PTGER2 p.Thr270Ser Uncertain significance Single submitter
- PTGER2 p.Thr281Met Uncertain significance Single submitter
- PTGER2 p.Tyr285Cys Likely benign Single submitter
- PTGER2 p.Val329Asp Uncertain significance Single submitter
All PTGER2 variants
Benign/Likely benign 1
- p.Cys83Gly Multiple submitters
Likely benign 3
- p.Ala247Ser Single submitter
- p.Leu220= Single submitter
- p.Tyr285Cys Single submitter ⚠
Uncertain significance 36
- p.Ala42Val Single submitter ⚠
- p.Arg224Cys Single submitter ⚠
- p.Arg242Trp Single submitter ⚠
- p.Arg249Ser Single submitter ⚠
- p.Arg333Gln Single submitter ⚠
- p.Arg51Leu Single submitter ⚠
- p.Arg60His Single submitter ⚠
- p.Asp357Glu Single submitter ⚠
- p.Asp78Glu Single submitter ⚠
- p.Asp78His Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.Glu73Lys Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly243Val Single submitter ⚠
- p.Gly246Trp Single submitter ⚠
- p.Gly2Asp Single submitter ⚠
- p.Ile264Phe Single submitter ⚠
- p.Ile264Thr Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Met116Arg Single submitter ⚠
- p.Met116Val Single submitter ⚠
- p.Met256Arg Single submitter ⚠
- p.Met269Val Single submitter ⚠
- p.Met286Val Single submitter ⚠
- p.Pro104Leu Single submitter ⚠
- p.Pro312Leu Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Ser28Gly Single submitter ⚠
- p.Ser335Leu Single submitter ⚠
- p.Ser33Leu Single submitter ⚠
- p.Thr270Ser Single submitter ⚠
- p.Thr281Met Single submitter ⚠
- p.Trp18Arg Single submitter ⚠
- p.Val329Asp Single submitter ⚠
- p.Val69Met Single submitter ⚠
- p.Val71Gly Single submitter ⚠