PTGER3 — 41 ClinVar variants
All ClinVar germline PTGER3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
1 Benign · 4 Likely benign · 36 Uncertain significance
Full PTGER3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTGER3 p.Arg16His Uncertain significance Single submitter
- PTGER3 p.Arg29Leu Uncertain significance Single submitter
- PTGER3 p.Arg34Pro Uncertain significance Single submitter
- PTGER3 p.Arg39His Uncertain significance Single submitter
- PTGER3 p.Glu324Gly Uncertain significance Single submitter
- PTGER3 p.Gly216Ser Uncertain significance Single submitter
- PTGER3 p.Gly274Ser Uncertain significance Single submitter
- PTGER3 p.Gly48Arg Uncertain significance Single submitter
- PTGER3 p.Gly6Arg Uncertain significance Single submitter
- PTGER3 p.Gly8Glu Uncertain significance Single submitter
- PTGER3 p.His314Gln Uncertain significance Single submitter
- PTGER3 p.Ile330Thr Uncertain significance Single submitter
- PTGER3 p.Leu228Phe Uncertain significance Single submitter
- PTGER3 p.Leu97Phe Uncertain significance Single submitter
- PTGER3 p.Met169Arg Uncertain significance Single submitter
- PTGER3 p.Pro297Leu Uncertain significance Single submitter
- PTGER3 p.Pro41Ala Uncertain significance Single submitter
- PTGER3 p.Ser144Pro Uncertain significance Single submitter
- PTGER3 p.Trp164Arg Uncertain significance Single submitter
- PTGER3 p.Trp25Gly Uncertain significance Single submitter
- PTGER3 p.Val312Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PTGER3 variants
Benign 1
- p.Leu37= Multiple submitters
Likely benign 4
- p.Arg396Lys Single submitter
- p.Asn395fs Single submitter
- p.Ser43Pro Single submitter
- p.Thr22Pro Single submitter
Uncertain significance 36
- p.Arg16His Single submitter ⚠
- p.Arg29Leu Single submitter ⚠
- p.Arg34Pro Single submitter ⚠
- p.Arg361Ile Single submitter
- p.Arg361Ser Single submitter
- p.Arg39His Single submitter ⚠
- p.Arg80Pro Single submitter ⚠
- p.Cys371Tyr Single submitter
- p.Gln283His Single submitter ⚠
- p.Gln377Lys Single submitter
- p.Glu324Gly Single submitter ⚠
- p.Gly216Ser Single submitter ⚠
- p.Gly274Ser Single submitter ⚠
- p.Gly48Arg Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly8Glu Single submitter ⚠
- p.His314Gln Single submitter ⚠
- p.His384Leu Single submitter
- p.Ile159Thr Single submitter ⚠
- p.Ile330Thr Single submitter ⚠
- p.Leu228Phe Single submitter ⚠
- p.Leu402Pro Single submitter
- p.Leu72Phe Single submitter
- p.Leu97Phe Single submitter ⚠
- p.Lys356Asn Single submitter ⚠
- p.Met169Arg Single submitter ⚠
- p.Met360Thr Single submitter
- p.Pro297Leu Single submitter ⚠
- p.Pro41Ala Single submitter ⚠
- p.Ser144Pro Single submitter ⚠
- p.Ser232Pro Single submitter ⚠
- p.Ser404Arg Single submitter
- p.Thr390Ile Single submitter
- p.Trp164Arg Single submitter ⚠
- p.Trp25Gly Single submitter ⚠
- p.Val312Ala Single submitter ⚠