PTGER4 — 45 ClinVar variants
All ClinVar germline PTGER4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Benign · 2 Likely benign · 42 Uncertain significance
Full PTGER4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTGER4 p.Ala10Val Uncertain significance Single submitter
- PTGER4 p.Ala230Glu Uncertain significance Single submitter
- PTGER4 p.Ala466Pro Uncertain significance Single submitter
- PTGER4 p.Arg239Trp Uncertain significance Single submitter
- PTGER4 p.Arg262Gly Uncertain significance Single submitter
- PTGER4 p.Arg262His Uncertain significance Single submitter
- PTGER4 p.Arg304Gln Uncertain significance Single submitter
- PTGER4 p.Arg368Ser Uncertain significance Single submitter
- PTGER4 p.Arg378Cys Uncertain significance Single submitter
- PTGER4 p.Asn177Lys Uncertain significance Single submitter
- PTGER4 p.Asp403Asn Uncertain significance Single submitter
- PTGER4 p.Gln313Arg Uncertain significance Single submitter
- PTGER4 p.Gln446Arg Uncertain significance Single submitter
- PTGER4 p.Glu357Lys Uncertain significance Single submitter
- PTGER4 p.Gly208Ala Uncertain significance Single submitter
- PTGER4 p.Gly88Asp Uncertain significance Single submitter
- PTGER4 p.His241Pro Uncertain significance Single submitter
- PTGER4 p.His362Arg Uncertain significance Single submitter
- PTGER4 p.Leu434Trp Uncertain significance Single submitter
- PTGER4 p.Leu70Val Uncertain significance Single submitter
- PTGER4 p.Lys386Arg Uncertain significance Single submitter
- PTGER4 p.Met156Ile Uncertain significance Single submitter
- PTGER4 p.Met156Leu Uncertain significance Single submitter
- PTGER4 p.Met187Val Uncertain significance Single submitter
- PTGER4 p.Pro14Ala Uncertain significance Single submitter
- PTGER4 p.Pro477Leu Uncertain significance Single submitter
- PTGER4 p.Ser11Phe Uncertain significance Single submitter
- PTGER4 p.Ser238Thr Uncertain significance Single submitter
- PTGER4 p.Ser338Arg Uncertain significance Single submitter
- PTGER4 p.Ser382Cys Uncertain significance Single submitter
- PTGER4 p.Thr335Arg Uncertain significance Single submitter
- PTGER4 p.Thr428Pro Uncertain significance Single submitter
- PTGER4 p.Tyr130His Uncertain significance Single submitter
- PTGER4 p.Val200Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- PTGER4 p.Arg262Cys Uncertain significance Single submitter
- PTGER4 p.Ile98Phe Uncertain significance Single submitter
- PTGER4 p.Met270Ile Uncertain significance Single submitter
- PTGER4 p.Phe254Leu Uncertain significance Single submitter
- PTGER4 p.Phe260Leu Uncertain significance Single submitter
- PTGER4 p.Pro86Ser Uncertain significance Single submitter
- PTGER4 p.Thr56Ala Uncertain significance Single submitter
- PTGER4 p.Val206Ala Uncertain significance Single submitter
All PTGER4 variants
Benign 1
- p.Val294Ile Multiple submitters
Likely benign 2
- p.Glu357Asp Single submitter
- p.Gly461Ser Single submitter
Uncertain significance 42
- p.Ala10Val Single submitter ⚠
- p.Ala230Glu Single submitter ⚠
- p.Ala466Pro Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg262Cys Single submitter ⚠
- p.Arg262Gly Single submitter ⚠
- p.Arg262His Single submitter ⚠
- p.Arg304Gln Single submitter ⚠
- p.Arg368Ser Single submitter ⚠
- p.Arg378Cys Single submitter ⚠
- p.Asn177Lys Single submitter ⚠
- p.Asp403Asn Single submitter ⚠
- p.Gln313Arg Single submitter ⚠
- p.Gln446Arg Single submitter ⚠
- p.Glu357Lys Single submitter ⚠
- p.Gly208Ala Single submitter ⚠
- p.Gly88Asp Single submitter ⚠
- p.His241Pro Single submitter ⚠
- p.His362Arg Single submitter ⚠
- p.Ile98Phe Single submitter ⚠
- p.Leu434Trp Single submitter ⚠
- p.Leu70Val Single submitter ⚠
- p.Lys386Arg Single submitter ⚠
- p.Met156Ile Single submitter ⚠
- p.Met156Leu Single submitter ⚠
- p.Met187Val Single submitter ⚠
- p.Met270Ile Single submitter ⚠
- p.Phe254Leu Single submitter ⚠
- p.Phe260Leu Single submitter ⚠
- p.Pro14Ala Single submitter ⚠
- p.Pro477Leu Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser11Phe Single submitter ⚠
- p.Ser238Thr Single submitter ⚠
- p.Ser338Arg Single submitter ⚠
- p.Ser382Cys Single submitter ⚠
- p.Thr335Arg Single submitter ⚠
- p.Thr428Pro Single submitter ⚠
- p.Thr56Ala Single submitter ⚠
- p.Tyr130His Single submitter ⚠
- p.Val200Ile Single submitter ⚠
- p.Val206Ala Single submitter ⚠