PTGES2 — 53 ClinVar variants
All ClinVar germline PTGES2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Benign · 3 Likely benign · 49 Uncertain significance
Full PTGES2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTGES2 p.Ala10Gly Uncertain significance Single submitter
- PTGES2 p.Ala171Ser Uncertain significance Single submitter
- PTGES2 p.Ala238Val Uncertain significance Single submitter
- PTGES2 p.Ala259Val Uncertain significance Single submitter
- PTGES2 p.Ala284Val Uncertain significance Single submitter
- PTGES2 p.Arg117Gln Uncertain significance Single submitter
- PTGES2 p.Arg136His Uncertain significance Single submitter
- PTGES2 p.Arg235Gln Uncertain significance Single submitter
- PTGES2 p.Arg266Ser Uncertain significance Single submitter
- PTGES2 p.Arg304Cys Uncertain significance Single submitter
- PTGES2 p.Arg304His Uncertain significance Single submitter
- PTGES2 p.Arg322Gln Uncertain significance Single submitter
- PTGES2 p.Arg342Cys Uncertain significance Single submitter
- PTGES2 p.Arg99His Uncertain significance Single submitter
- PTGES2 p.Asp240Asn Uncertain significance Single submitter
- PTGES2 p.Asp84Asn Uncertain significance Single submitter
- PTGES2 p.Gln101Arg Uncertain significance Single submitter
- PTGES2 p.Gln219Glu Uncertain significance Single submitter
- PTGES2 p.Glu372Lys Uncertain significance Single submitter
- PTGES2 p.Gly271Arg Uncertain significance Single submitter
- PTGES2 p.Gly282Asp Uncertain significance Single submitter
- PTGES2 p.Gly326Glu Uncertain significance Single submitter
- PTGES2 p.Gly327Asp Uncertain significance Single submitter
- PTGES2 p.His297Tyr Uncertain significance Single submitter
- PTGES2 p.His86Gln Uncertain significance Single submitter
- PTGES2 p.Leu288Phe Uncertain significance Single submitter
- PTGES2 p.Leu307Phe Uncertain significance Single submitter
- PTGES2 p.Lys173Gln Uncertain significance Single submitter
- PTGES2 p.Lys233Asn Uncertain significance Single submitter
- PTGES2 p.Lys269Arg Uncertain significance Single submitter
- PTGES2 p.Met325Leu Uncertain significance Single submitter
- PTGES2 p.Pro248Ala Uncertain significance Single submitter
- PTGES2 p.Pro248Ser Uncertain significance Single submitter
- PTGES2 p.Thr109Met Uncertain significance Single submitter
- PTGES2 p.Thr203Ile Uncertain significance Single submitter
- PTGES2 p.Thr357Met Uncertain significance Single submitter
- PTGES2 p.Trp314Gly Uncertain significance Single submitter
- PTGES2 p.Val277Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- PTGES2 p.Arg266Cys Uncertain significance Single submitter
- PTGES2 p.Arg365Trp Uncertain significance Single submitter
- PTGES2 p.Gly275Asp Uncertain significance Single submitter
- PTGES2 p.Ile185Phe Uncertain significance Single submitter
- PTGES2 p.Ser178Leu Uncertain significance Single submitter
- PTGES2 p.Val303Met Uncertain significance Single submitter
All PTGES2 variants
Benign 1
- p.Lys269Asn Multiple submitters
Likely benign 3
- p.Ala376Val Single submitter
- p.Glu184Asp Single submitter
- p.Val277Met Single submitter
Uncertain significance 49
- p.Ala10Gly Single submitter ⚠
- p.Ala171Ser Single submitter ⚠
- p.Ala238Val Single submitter ⚠
- p.Ala259Val Single submitter ⚠
- p.Ala284Val Single submitter ⚠
- p.Arg117Gln Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg252His Single submitter
- p.Arg266Cys Single submitter ⚠
- p.Arg266Ser Single submitter ⚠
- p.Arg304Cys Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg322Gln Single submitter ⚠
- p.Arg342Cys Single submitter ⚠
- p.Arg365Trp Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Asp240Asn Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Gln101Arg Single submitter ⚠
- p.Gln219Glu Single submitter ⚠
- p.Glu204Lys Single submitter
- p.Glu372Lys Single submitter ⚠
- p.Gly271Arg Single submitter ⚠
- p.Gly275Asp Single submitter ⚠
- p.Gly282Asp Single submitter ⚠
- p.Gly326Glu Single submitter ⚠
- p.Gly327Asp Single submitter ⚠
- p.His297Tyr Single submitter ⚠
- p.His86Gln Single submitter ⚠
- p.Ile150Met Single submitter
- p.Ile185Phe Single submitter ⚠
- p.Leu288Phe Single submitter ⚠
- p.Leu307Phe Single submitter ⚠
- p.Lys141Glu Single submitter
- p.Lys173Gln Single submitter ⚠
- p.Lys233Asn Single submitter ⚠
- p.Lys269Arg Single submitter ⚠
- p.Met325Leu Single submitter ⚠
- p.Pro248Ala Single submitter ⚠
- p.Pro248Ser Single submitter ⚠
- p.Ser178Leu Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Thr203Ile Single submitter ⚠
- p.Thr357Met Single submitter ⚠
- p.Trp314Gly Single submitter ⚠
- p.Val277Leu Single submitter ⚠
- p.Val303Met Single submitter ⚠
- p.Val340Met Single submitter