PTP4A2 — 11 ClinVar variants
All ClinVar germline PTP4A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
11 Uncertain significance
Full PTP4A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 3
The independent predictors disagree with each other — read with care.
All PTP4A2 variants
Uncertain significance 11
- p.Ala48Val Single submitter ⚠
- p.Asn161Ser Single submitter ⚠
- p.Asn24Ser Single submitter ⚠
- p.Asn2Ser Single submitter
- p.Cys119Tyr Single submitter
- p.His163Leu Single submitter ⚠
- p.Met14Leu Single submitter ⚠
- p.Tyr11Cys Single submitter ⚠
- p.Val166Ala Single submitter
- p.Val55Ala Single submitter ⚠
- p.Val62Ile Single submitter ⚠