PTP4A3 — 36 ClinVar variants
All ClinVar germline PTP4A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Benign · 2 Likely benign · 33 Uncertain significance
Full PTP4A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTP4A3 p.Ala129Thr Uncertain significance Single submitter
- PTP4A3 p.Ala28Thr Uncertain significance Single submitter
- PTP4A3 p.Arg138Cys Uncertain significance Single submitter
- PTP4A3 p.Arg159Trp Uncertain significance Single submitter
- PTP4A3 p.Arg6His Uncertain significance Single submitter
- PTP4A3 p.Asn24Lys Uncertain significance Single submitter
- PTP4A3 p.Asn27Asp Uncertain significance Single submitter
- PTP4A3 p.Asn27Thr Uncertain significance Single submitter
- PTP4A3 p.Asp54Gly Uncertain significance Single submitter
- PTP4A3 p.Cys171Phe Uncertain significance Single submitter
- PTP4A3 p.Gly97Ser Uncertain significance Single submitter
- PTP4A3 p.His103Tyr Uncertain significance Single submitter
- PTP4A3 p.Ile34Val Uncertain significance Single submitter
- PTP4A3 p.Lys39Asn Uncertain significance Single submitter
- PTP4A3 p.Lys79Arg Uncertain significance Single submitter
- PTP4A3 p.Met17Val Uncertain significance Single submitter
- PTP4A3 p.Pro163Ser Uncertain significance Single submitter
- PTP4A3 p.Pro7Gln Uncertain significance Single submitter
- PTP4A3 p.Pro7Leu Uncertain significance Single submitter
- PTP4A3 p.Ser122Asn Uncertain significance Single submitter
- PTP4A3 p.Ser13Thr Uncertain significance Single submitter
- PTP4A3 p.Thr147Ala Uncertain significance Single submitter
- PTP4A3 p.Thr22Ser Uncertain significance Single submitter
- PTP4A3 p.Thr56Met Uncertain significance Single submitter
- PTP4A3 p.Val105Met Uncertain significance Single submitter
- PTP4A3 p.Val172Ile Uncertain significance Single submitter
- PTP4A3 p.Val80Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All PTP4A3 variants
Benign 1
- c.199-5C>T Multiple submitters
Likely benign 2
- c.-3G>T Single submitter
- p.Val88Leu Single submitter
Uncertain significance 33
- p.Ala129Thr Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg138His Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg159Trp Single submitter ⚠
- p.Arg3Gln Single submitter
- p.Arg6His Single submitter ⚠
- p.Asn24Lys Single submitter ⚠
- p.Asn27Asp Single submitter ⚠
- p.Asn27Thr Single submitter ⚠
- p.Asp54Gly Single submitter ⚠
- p.Cys171Phe Single submitter ⚠
- p.Gly97Ser Single submitter ⚠
- p.His103Tyr Single submitter ⚠
- p.Ile133Val Single submitter ⚠
- p.Ile34Val Single submitter ⚠
- p.Lys39Asn Single submitter ⚠
- p.Lys79Arg Single submitter ⚠
- p.Met17Val Single submitter ⚠
- p.Pro163Ser Single submitter ⚠
- p.Pro7Gln Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser122Asn Single submitter ⚠
- p.Ser13Thr Single submitter ⚠
- p.Thr147Ala Single submitter ⚠
- p.Thr165Met Single submitter ⚠
- p.Thr165Pro Single submitter ⚠
- p.Thr22Ser Single submitter ⚠
- p.Thr56Met Single submitter ⚠
- p.Val105Met Single submitter ⚠
- p.Val172Ile Single submitter ⚠
- p.Val80Ile Single submitter ⚠