PTPN14 — 259 ClinVar variants
All ClinVar germline PTPN14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 138 flagged for review →
3 Pathogenic · 1 Likely pathogenic · 60 Benign · 7 Benign/Likely benign · 33 Likely benign · 155 Uncertain significance
Full PTPN14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 138
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
PTPN14 p.Arg640His
Likely pathogenic
No assertion criteria
esophageal atresia/tracheoesophageal fistula
Predictors lean, ClinVar uncertain 120
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTPN14 p.Ala856Pro Uncertain significance Multiple submitters
-
PTPN14 p.Ile1167Thr
Uncertain significance
Multiple submitters
lymphedema-posterior choanal atresia syndrome
-
PTPN14 p.Ile953Met
Uncertain significance
Multiple submitters
lymphedema-posterior choanal atresia syndrome
-
PTPN14 p.Met866Val
Uncertain significance
Multiple submitters
lymphedema-posterior choanal atresia syndrome
-
PTPN14 p.Pro571Gln
Uncertain significance
Multiple submitters
lymphedema-posterior choanal atresia syndrome
-
PTPN14 p.Val616Met
Uncertain significance
Multiple submitters
lymphedema-posterior choanal atresia syndrome
-
PTPN14 p.Val886Ala
Uncertain significance
Multiple submitters
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Ala365Ser Uncertain significance Single submitter
-
PTPN14 p.Ala739Val
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Ala763Ser Uncertain significance Single submitter
- PTPN14 p.Ala798Asp Uncertain significance Single submitter
- PTPN14 p.Ala860Thr Uncertain significance Single submitter
- PTPN14 p.Ala929Val Uncertain significance Single submitter
- PTPN14 p.Arg1113Gln Uncertain significance Single submitter
- PTPN14 p.Arg132Gly Uncertain significance Single submitter
- PTPN14 p.Arg140Gln Uncertain significance Single submitter
- PTPN14 p.Arg320His Uncertain significance Single submitter
- PTPN14 p.Arg422Pro Uncertain significance Single submitter
- PTPN14 p.Arg572Gln Uncertain significance Single submitter
- PTPN14 p.Arg572Leu Uncertain significance Single submitter
- PTPN14 p.Arg57Gln Uncertain significance Single submitter
- PTPN14 p.Arg600Trp Uncertain significance Single submitter
- PTPN14 p.Arg667Pro Uncertain significance Single submitter
- PTPN14 p.Arg728Gln Uncertain significance Single submitter
- PTPN14 p.Arg743Cys Uncertain significance Single submitter
- PTPN14 p.Arg881Gln Uncertain significance Single submitter
- PTPN14 p.Arg9Trp Uncertain significance Single submitter
- PTPN14 p.Asn105Ser Uncertain significance Single submitter
- PTPN14 p.Asn1104Ser Uncertain significance Single submitter
- PTPN14 p.Asn225Ser Uncertain significance Single submitter
- PTPN14 p.Asn273Ser Uncertain significance Single submitter
-
PTPN14 p.Asn398Ser
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Asn800Ser Uncertain significance Single submitter
-
PTPN14 p.Asp152Glu
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Asp152Val Uncertain significance Single submitter
- PTPN14 p.Cys229Arg Uncertain significance Single submitter
- PTPN14 p.Gln546Glu Uncertain significance Single submitter
- PTPN14 p.Gln619Arg Uncertain significance Single submitter
- PTPN14 p.Gln736Pro Uncertain significance Single submitter
- PTPN14 p.Glu1012Gln Uncertain significance Single submitter
-
PTPN14 p.Glu1135Gln
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Glu1135Lys Uncertain significance Single submitter
- PTPN14 p.Glu175Lys Uncertain significance Single submitter
- PTPN14 p.Glu34Lys Uncertain significance Single submitter
- PTPN14 p.Glu678Lys Uncertain significance Single submitter
- PTPN14 p.Glu679Gly Uncertain significance Single submitter
- PTPN14 p.Glu906Asp Uncertain significance Single submitter
- PTPN14 p.Gly246Glu Uncertain significance Single submitter
- PTPN14 p.Gly501Arg Uncertain significance Single submitter
- PTPN14 p.Gly592Ser Uncertain significance Single submitter
- PTPN14 p.Gly675Glu Uncertain significance Single submitter
- PTPN14 p.Gly805Ser Uncertain significance Single submitter
- PTPN14 p.His371Gln Uncertain significance Single submitter
- PTPN14 p.His458Arg Uncertain significance Single submitter
- PTPN14 p.His494Gln Uncertain significance Single submitter
-
PTPN14 p.His585Pro
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Ile245Thr Uncertain significance Single submitter
- PTPN14 p.Ile435Val Uncertain significance Single submitter
- PTPN14 p.Leu268Val Uncertain significance Single submitter
- PTPN14 p.Leu397Phe Uncertain significance Single submitter
-
PTPN14 p.Leu628Val
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Leu689Val Uncertain significance Single submitter
- PTPN14 p.Lys1018Asn Uncertain significance Single submitter
- PTPN14 p.Lys1171Met Uncertain significance Single submitter
- PTPN14 p.Lys300Glu Uncertain significance Single submitter
- PTPN14 p.Lys695Arg Uncertain significance Single submitter
- PTPN14 p.Lys730Arg Uncertain significance Single submitter
- PTPN14 p.Lys84Arg Uncertain significance Single submitter
- PTPN14 p.Lys852Arg Uncertain significance Single submitter
- PTPN14 p.Lys920Gln Uncertain significance Single submitter
- PTPN14 p.Met558Thr Uncertain significance Single submitter
- PTPN14 p.Met653Arg Uncertain significance Single submitter
- PTPN14 p.Met656Thr Uncertain significance Single submitter
- PTPN14 p.Met656Val Uncertain significance Single submitter
- PTPN14 p.Met665Val Uncertain significance Single submitter
- PTPN14 p.Met775Ile Uncertain significance Single submitter
- PTPN14 p.Met908Thr Uncertain significance Single submitter
- PTPN14 p.Phe21Ile Uncertain significance Single submitter
- PTPN14 p.Pro1083Thr Uncertain significance Single submitter
- PTPN14 p.Pro1115Ser Uncertain significance Single submitter
- PTPN14 p.Pro317Leu Uncertain significance Single submitter
- PTPN14 p.Pro427Thr Uncertain significance Single submitter
-
PTPN14 p.Pro525Leu
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
-
PTPN14 p.Pro528Leu
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Pro615Leu Uncertain significance Single submitter
- PTPN14 p.Pro687Ser Uncertain significance Single submitter
-
PTPN14 p.Pro722Ser
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Ser1028Ala Uncertain significance Single submitter
- PTPN14 p.Ser387Arg Uncertain significance Single submitter
- PTPN14 p.Ser526Asn Uncertain significance Single submitter
- PTPN14 p.Ser642Gly Uncertain significance Single submitter
- PTPN14 p.Ser648Asn Uncertain significance Single submitter
- PTPN14 p.Ser683Ile Uncertain significance Single submitter
- PTPN14 p.Ser803Pro Uncertain significance Single submitter
- PTPN14 p.Ser835Phe Uncertain significance Single submitter
- PTPN14 p.Ser839Gly Uncertain significance Single submitter
- PTPN14 p.Thr1075Ser Uncertain significance Single submitter
- PTPN14 p.Thr10Arg Uncertain significance Single submitter
- PTPN14 p.Thr261Ile Uncertain significance Single submitter
- PTPN14 p.Thr323Ile Uncertain significance Single submitter
- PTPN14 p.Thr555Met Uncertain significance Single submitter
- PTPN14 p.Thr59Met Uncertain significance Single submitter
- PTPN14 p.Thr889Ile Uncertain significance Single submitter
- PTPN14 p.Tyr1051Cys Uncertain significance Single submitter
- PTPN14 p.Tyr1074His Uncertain significance Single submitter
- PTPN14 p.Tyr348Cys Uncertain significance Single submitter
- PTPN14 p.Tyr562Ser Uncertain significance Single submitter
- PTPN14 p.Tyr61His Uncertain significance Single submitter
- PTPN14 p.Val1147Met Uncertain significance Single submitter
- PTPN14 p.Val146Gly Uncertain significance Single submitter
- PTPN14 p.Val166Ala Uncertain significance Single submitter
- PTPN14 p.Val222Ile Uncertain significance Single submitter
- PTPN14 p.Val340Ile Uncertain significance Single submitter
- PTPN14 p.Val388Ala Uncertain significance Single submitter
- PTPN14 p.Val391Ile Uncertain significance Single submitter
- PTPN14 p.Val436Met Uncertain significance Single submitter
-
PTPN14 p.Val50Met
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Val686Ile Uncertain significance Single submitter
- PTPN14 p.Val816Met Uncertain significance Single submitter
-
PTPN14 p.Lys453Asn
Uncertain significance
No assertion criteria
PTPN14-related disorder
Predictors split 17
The independent predictors disagree with each other — read with care.
- PTPN14 p.Arg12His Uncertain significance Single submitter
- PTPN14 p.Arg211Cys Uncertain significance Single submitter
- PTPN14 p.Arg293Trp Uncertain significance Single submitter
- PTPN14 p.Asp1076Val Uncertain significance Single submitter
- PTPN14 p.Asp700Val Uncertain significance Single submitter
- PTPN14 p.Gly214Ala Uncertain significance Single submitter
- PTPN14 p.Gly754Arg Uncertain significance Single submitter
- PTPN14 p.Gly974Arg Uncertain significance Single submitter
- PTPN14 p.His190Arg Uncertain significance Single submitter
- PTPN14 p.His706Tyr Uncertain significance Single submitter
-
PTPN14 p.Ile239Phe
Uncertain significance
Single submitter
lymphedema-posterior choanal atresia syndrome
- PTPN14 p.Leu873Phe Uncertain significance Single submitter
- PTPN14 p.Pro748Ser Uncertain significance Single submitter
- PTPN14 p.Pro987Ser Uncertain significance Single submitter
- PTPN14 p.Thr36Lys Uncertain significance Single submitter
- PTPN14 p.Tyr165His Uncertain significance Single submitter
- PTPN14 p.Val230Ala Uncertain significance Single submitter
All PTPN14 variants
Pathogenic 3
- p.Arg1016Ter Single submitter
- c.581+60_669+877del No assertion criteria lymphedema-posterior choanal atresia syndrome
- p.Leu135fs No assertion criteria lymphedema-posterior choanal atresia syndrome
Likely pathogenic 1
- p.Arg640His No assertion criteria esophageal atresia/tracheoesophageal fistula ⚠
Benign 60
- c.1067-97T>C Multiple submitters
- c.174+91T>C Multiple submitters
- c.175-114T>C Multiple submitters
- c.2545-181G>A Multiple submitters
- c.2545-81A>G Multiple submitters
- c.2688+26C>T Multiple submitters lymphedema-posterior choanal atresia syndrome
- c.2907+61G>A Multiple submitters
- c.3036+294A>C Multiple submitters
- c.3037-64T>C Multiple submitters
- c.3271+132A>G Multiple submitters
- c.3435+228G>A Multiple submitters
- c.443-8C>A Multiple submitters
- c.511-158G>T Multiple submitters
- c.511-186G>A Multiple submitters
- c.511-217G>A Multiple submitters
- c.511-58A>G Multiple submitters
- c.582-7A>G Multiple submitters
- c.758+5T>G Multiple submitters lymphedema-posterior choanal atresia syndrome
- c.929+193T>C Multiple submitters
- c.929+24del Multiple submitters lymphedema-posterior choanal atresia syndrome
- c.929+86T>C Multiple submitters
- c.930-54G>C Multiple submitters
- c.987+140T>G Multiple submitters
- c.987+154G>A Multiple submitters
- c.988-28C>A Multiple submitters
- c.-154-119C>A Multiple submitters
- c.-154-19A>G Multiple submitters
- c.-154-47T>C Multiple submitters
- c.-26G>A Multiple submitters lymphedema-posterior choanal atresia syndrome
- c.*26G>A Multiple submitters lymphedema-posterior choanal atresia syndrome
- p.Ala90Thr Multiple submitters
- p.Arg326= Multiple submitters lymphedema-posterior choanal atresia syndrome
- p.Asn1104= Multiple submitters
- p.Glu1084= Multiple submitters lymphedema-posterior choanal atresia syndrome
- p.Glu189Gly Multiple submitters
- p.His1060= Multiple submitters
- p.Pro1115Leu Multiple submitters
- p.Ser461= Multiple submitters
- p.Thr134= Multiple submitters
- p.Thr629Met Multiple submitters
- c.174+165G>A Single submitter
- c.2544+114G>A Single submitter
- c.2544+171A>T Single submitter
- c.2908-302C>T Single submitter
- c.3272-268T>A Single submitter
- c.3435+306G>A Single submitter
- c.581+147C>T Single submitter
- c.670-183G>C Single submitter
- c.670-9C>T Single submitter
- c.758+286G>A Single submitter
- c.759-142G>T Single submitter
- c.847-258T>C Single submitter
- c.-154-136C>T Single submitter
- c.-154-234T>C Single submitter
- c.-154-284A>T Single submitter
- c.-154-345C>T Single submitter
- c.-154-94_-154-84del Single submitter
- c.*186del Single submitter
- p.Glu715_Glu716del Single submitter
- p.Val138= Single submitter
Benign/Likely benign 7
- p.Arg877Gln Multiple submitters
- p.Asp838= Multiple submitters
- p.His360Pro Multiple submitters
- p.Ser400= Multiple submitters
- p.Ser418Asn Multiple submitters
- p.Thr282= Multiple submitters
- p.Thr353= Multiple submitters
Likely benign 33
- c.581+5G>A Multiple submitters
- p.Arg668Cys Multiple submitters
- p.Gly504= Multiple submitters
- p.Lys84= Multiple submitters
- p.Pro944= Multiple submitters
- p.Thr1046= Multiple submitters
- c.174+6del Single submitter
- c.175-4C>T Single submitter
- c.443-20C>T Single submitter
- c.511-10A>G Single submitter
- c.582-13A>G Single submitter
- c.759-3C>T Single submitter
- p.Ala739= Single submitter
- p.Ala934= Single submitter
- p.Arg211= Single submitter
- p.Asn1144= Single submitter
- p.Asn31Ser Single submitter
- p.Glu716del Single submitter
- p.His634= Single submitter
- p.Met726Val Single submitter
- p.Pro567= Single submitter
- p.Pro677= Single submitter
- p.Pro722= Single submitter
- p.Thr1046Arg Single submitter
- p.Thr351= Single submitter
- p.Thr989= Single submitter
- p.Tyr1035= Single submitter
- c.1067-4G>A No assertion criteria PTPN14-related disorder
- p.Arg491Trp No assertion criteria PTPN14-related disorder
- p.Asn521= No assertion criteria PTPN14-related disorder
- p.Leu47= No assertion criteria PTPN14-related disorder
- p.Thr384= No assertion criteria PTPN14-related disorder
- p.Val505= No assertion criteria PTPN14-related disorder
Uncertain significance 155
- p.Ala856Pro Multiple submitters ⚠
- p.Ile1167Thr Multiple submitters lymphedema-posterior choanal atresia syndrome ⚠
- p.Ile953Met Multiple submitters lymphedema-posterior choanal atresia syndrome ⚠
- p.Met866Val Multiple submitters lymphedema-posterior choanal atresia syndrome ⚠
- p.Pro571Gln Multiple submitters lymphedema-posterior choanal atresia syndrome ⚠
- p.Val616Met Multiple submitters lymphedema-posterior choanal atresia syndrome ⚠
- p.Val886Ala Multiple submitters lymphedema-posterior choanal atresia syndrome ⚠
- c.1066+3A>T Single submitter
- c.511-3T>C Single submitter lymphedema-posterior choanal atresia syndrome
- c.-154-22749A>G Single submitter lymphedema-posterior choanal atresia syndrome
- c.-154-42562G>A Single submitter lymphedema-posterior choanal atresia syndrome
- c.*6320C>T Single submitter lymphedema-posterior choanal atresia syndrome
- p.Ala365Ser Single submitter ⚠
- p.Ala739Glu Single submitter
- p.Ala739Val Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Ala763Ser Single submitter ⚠
- p.Ala798Asp Single submitter ⚠
- p.Ala860Thr Single submitter ⚠
- p.Ala929Val Single submitter ⚠
- p.Arg1113Gln Single submitter ⚠
- p.Arg12His Single submitter ⚠
- p.Arg132Gly Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg211Cys Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg422Pro Single submitter ⚠
- p.Arg430Trp Single submitter
- p.Arg450Leu Single submitter
- p.Arg572Gln Single submitter ⚠
- p.Arg572Leu Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg600Trp Single submitter ⚠
- p.Arg667Pro Single submitter ⚠
- p.Arg728Gln Single submitter ⚠
- p.Arg743Cys Single submitter ⚠
- p.Arg881Gln Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asn105Ser Single submitter ⚠
- p.Asn1104Ser Single submitter ⚠
- p.Asn225Ser Single submitter ⚠
- p.Asn228Lys Single submitter
- p.Asn273Ser Single submitter ⚠
- p.Asn398Ser Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Asn800Ser Single submitter ⚠
- p.Asp1076Val Single submitter ⚠
- p.Asp152Glu Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Asp152Val Single submitter ⚠
- p.Asp700Val Single submitter ⚠
- p.Cys229Arg Single submitter ⚠
- p.Gln546Glu Single submitter ⚠
- p.Gln610His Single submitter
- p.Gln619Arg Single submitter ⚠
- p.Gln736Pro Single submitter ⚠
- p.Glu1012Gln Single submitter ⚠
- p.Glu1135Gln Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Glu1135Lys Single submitter ⚠
- p.Glu175Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu678Lys Single submitter ⚠
- p.Glu679Gly Single submitter ⚠
- p.Glu906Asp Single submitter ⚠
- p.Gly1001Arg Single submitter
- p.Gly214Ala Single submitter ⚠
- p.Gly227Ter Single submitter lymphedema-posterior choanal atresia syndrome
- p.Gly246Glu Single submitter ⚠
- p.Gly501Arg Single submitter ⚠
- p.Gly592Ser Single submitter ⚠
- p.Gly675Glu Single submitter ⚠
- p.Gly754Arg Single submitter ⚠
- p.Gly754Ser Single submitter
- p.Gly805Ser Single submitter ⚠
- p.Gly974Arg Single submitter ⚠
- p.His190Arg Single submitter ⚠
- p.His371Gln Single submitter ⚠
- p.His458Arg Single submitter ⚠
- p.His494Gln Single submitter ⚠
- p.His585Pro Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.His706Tyr Single submitter ⚠
- p.Ile239Phe Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Ile245Thr Single submitter ⚠
- p.Ile435Val Single submitter ⚠
- p.Leu268Val Single submitter ⚠
- p.Leu397Phe Single submitter ⚠
- p.Leu628Val Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Leu689Val Single submitter ⚠
- p.Leu873Phe Single submitter ⚠
- p.Lys1018Asn Single submitter ⚠
- p.Lys1171Met Single submitter ⚠
- p.Lys300Glu Single submitter ⚠
- p.Lys695Arg Single submitter ⚠
- p.Lys730Arg Single submitter ⚠
- p.Lys84Arg Single submitter ⚠
- p.Lys852Arg Single submitter ⚠
- p.Lys920Gln Single submitter ⚠
- p.Met558Thr Single submitter ⚠
- p.Met653Arg Single submitter ⚠
- p.Met656Thr Single submitter ⚠
- p.Met656Val Single submitter ⚠
- p.Met665Val Single submitter ⚠
- p.Met775Ile Single submitter ⚠
- p.Met908Thr Single submitter ⚠
- p.Phe21Ile Single submitter ⚠
- p.Pro1083Thr Single submitter ⚠
- p.Pro1115Ser Single submitter ⚠
- p.Pro317Leu Single submitter ⚠
- p.Pro408Leu Single submitter
- p.Pro427Thr Single submitter ⚠
- p.Pro525Leu Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Pro528Leu Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Pro615Leu Single submitter ⚠
- p.Pro687Ser Single submitter ⚠
- p.Pro722Ser Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Pro748Ser Single submitter ⚠
- p.Pro987Ser Single submitter ⚠
- p.Ser1028Ala Single submitter ⚠
- p.Ser387Arg Single submitter ⚠
- p.Ser526Asn Single submitter ⚠
- p.Ser605Leu Single submitter
- p.Ser642Gly Single submitter ⚠
- p.Ser648Asn Single submitter ⚠
- p.Ser683Ile Single submitter ⚠
- p.Ser803Pro Single submitter ⚠
- p.Ser835Phe Single submitter ⚠
- p.Ser839Gly Single submitter ⚠
- p.Thr1054Met Single submitter lymphedema-posterior choanal atresia syndrome
- p.Thr1075Ile Single submitter
- p.Thr1075Ser Single submitter ⚠
- p.Thr10Arg Single submitter ⚠
- p.Thr261Ile Single submitter ⚠
- p.Thr323Ile Single submitter ⚠
- p.Thr36Lys Single submitter ⚠
- p.Thr555Met Single submitter ⚠
- p.Thr59Met Single submitter ⚠
- p.Thr889Ile Single submitter ⚠
- p.Tyr1051Cys Single submitter ⚠
- p.Tyr1074His Single submitter ⚠
- p.Tyr165His Single submitter ⚠
- p.Tyr348Cys Single submitter ⚠
- p.Tyr562Ser Single submitter ⚠
- p.Tyr61His Single submitter ⚠
- p.Val1147Met Single submitter ⚠
- p.Val146Gly Single submitter ⚠
- p.Val166Ala Single submitter ⚠
- p.Val222Ile Single submitter ⚠
- p.Val230Ala Single submitter ⚠
- p.Val340Ile Single submitter ⚠
- p.Val388Ala Single submitter ⚠
- p.Val391Ile Single submitter ⚠
- p.Val436Met Single submitter ⚠
- p.Val50Met Single submitter lymphedema-posterior choanal atresia syndrome ⚠
- p.Val686Ile Single submitter ⚠
- p.Val76Leu Single submitter
- p.Val816Met Single submitter ⚠
- p.Lys453Asn No assertion criteria PTPN14-related disorder ⚠