PTPN18 — 87 ClinVar variants
All ClinVar germline PTPN18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
1 Likely benign · 86 Uncertain significance
Full PTPN18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 69
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTPN18 p.Ala146Asp Uncertain significance Single submitter
- PTPN18 p.Ala273Thr Uncertain significance Single submitter
- PTPN18 p.Ala273Val Uncertain significance Single submitter
- PTPN18 p.Ala35Thr Uncertain significance Single submitter
- PTPN18 p.Ala362Thr Uncertain significance Single submitter
- PTPN18 p.Ala362Val Uncertain significance Single submitter
- PTPN18 p.Ala366Thr Uncertain significance Single submitter
- PTPN18 p.Ala386Gly Uncertain significance Single submitter
- PTPN18 p.Ala401Thr Uncertain significance Single submitter
- PTPN18 p.Arg138Gln Uncertain significance Single submitter
- PTPN18 p.Arg143Gln Uncertain significance Single submitter
- PTPN18 p.Arg198Cys Uncertain significance Single submitter
- PTPN18 p.Arg198His Uncertain significance Single submitter
- PTPN18 p.Arg216His Uncertain significance Single submitter
- PTPN18 p.Arg331His Uncertain significance Single submitter
- PTPN18 p.Arg381Cys Uncertain significance Single submitter
- PTPN18 p.Arg395Gly Uncertain significance Single submitter
- PTPN18 p.Arg443Cys Uncertain significance Single submitter
- PTPN18 p.Arg53Gln Uncertain significance Single submitter
- PTPN18 p.Arg93Pro Uncertain significance Single submitter
- PTPN18 p.Asn90Ser Uncertain significance Single submitter
- PTPN18 p.Asp315Asn Uncertain significance Single submitter
- PTPN18 p.Asp417Glu Uncertain significance Single submitter
- PTPN18 p.Gln247Arg Uncertain significance Single submitter
- PTPN18 p.Gln358His Uncertain significance Single submitter
- PTPN18 p.Gln371Arg Uncertain significance Single submitter
- PTPN18 p.Glu148Gln Uncertain significance Single submitter
- PTPN18 p.Glu150Lys Uncertain significance Single submitter
- PTPN18 p.Glu308Lys Uncertain significance Single submitter
- PTPN18 p.Gly221Arg Uncertain significance Single submitter
- PTPN18 p.Gly234Trp Uncertain significance Single submitter
- PTPN18 p.Gly365Asp Uncertain significance Single submitter
- PTPN18 p.Gly367Arg Uncertain significance Single submitter
- PTPN18 p.Gly375Glu Uncertain significance Single submitter
- PTPN18 p.Gly422Arg Uncertain significance Single submitter
- PTPN18 p.Gly44Ser Uncertain significance Single submitter
- PTPN18 p.Gly51Ser Uncertain significance Single submitter
- PTPN18 p.His228Arg Uncertain significance Single submitter
- PTPN18 p.His302Arg Uncertain significance Single submitter
- PTPN18 p.His302Asp Uncertain significance Single submitter
- PTPN18 p.Ile127Val Uncertain significance Single submitter
- PTPN18 p.Ile171Ser Uncertain significance Single submitter
- PTPN18 p.Ile329Met Uncertain significance Single submitter
- PTPN18 p.Ile340Val Uncertain significance Single submitter
- PTPN18 p.Ile444Thr Uncertain significance Single submitter
- PTPN18 p.Leu152Arg Uncertain significance Single submitter
- PTPN18 p.Leu208Phe Uncertain significance Single submitter
- PTPN18 p.Leu260Ile Uncertain significance Single submitter
- PTPN18 p.Leu313Val Uncertain significance Single submitter
- PTPN18 p.Leu318Phe Uncertain significance Single submitter
- PTPN18 p.Leu75Arg Uncertain significance Single submitter
- PTPN18 p.Met210Ile Uncertain significance Single submitter
- PTPN18 p.Met291Ile Uncertain significance Single submitter
- PTPN18 p.Phe122Cys Uncertain significance Single submitter
- PTPN18 p.Pro312Ser Uncertain significance Single submitter
- PTPN18 p.Pro343Leu Uncertain significance Single submitter
- PTPN18 p.Ser259Asn Uncertain significance Single submitter
- PTPN18 p.Thr160Ser Uncertain significance Single submitter
- PTPN18 p.Thr372Arg Uncertain significance Single submitter
- PTPN18 p.Trp166Arg Uncertain significance Single submitter
- PTPN18 p.Tyr281Asn Uncertain significance Single submitter
- PTPN18 p.Tyr303Ser Uncertain significance Single submitter
- PTPN18 p.Tyr426Cys Uncertain significance Single submitter
- PTPN18 p.Tyr426Ser Uncertain significance Single submitter
- PTPN18 p.Tyr62Cys Uncertain significance Single submitter
- PTPN18 p.Tyr86His Uncertain significance Single submitter
- PTPN18 p.Val238Ile Uncertain significance Single submitter
- PTPN18 p.Val342Ala Uncertain significance Single submitter
- PTPN18 p.Val45Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- PTPN18 p.Arg143Trp Uncertain significance Single submitter
- PTPN18 p.Arg185His Uncertain significance Single submitter
- PTPN18 p.Arg271Gln Uncertain significance Single submitter
- PTPN18 p.Arg271Trp Uncertain significance Single submitter
- PTPN18 p.Arg321Trp Uncertain significance Single submitter
- PTPN18 p.Arg72Gly Uncertain significance Single submitter
- PTPN18 p.Asp114Glu Uncertain significance Single submitter
- PTPN18 p.Asp64His Uncertain significance Single submitter
- PTPN18 p.Gly221Asp Uncertain significance Single submitter
- PTPN18 p.Gly369Trp Uncertain significance Single submitter
- PTPN18 p.Lys125Glu Uncertain significance Single submitter
- PTPN18 p.Thr287Met Uncertain significance Single submitter
- PTPN18 p.Tyr144Phe Uncertain significance Single submitter
- PTPN18 p.Val211Gly Uncertain significance Single submitter
- PTPN18 p.Val65Met Uncertain significance Single submitter
All PTPN18 variants
Likely benign 1
- p.Ala386Val Single submitter
Uncertain significance 86
- p.Ala146Asp Single submitter ⚠
- p.Ala231Val Single submitter
- p.Ala273Thr Single submitter ⚠
- p.Ala273Val Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala362Val Single submitter ⚠
- p.Ala366Thr Single submitter ⚠
- p.Ala386Gly Single submitter ⚠
- p.Ala401Thr Single submitter ⚠
- p.Arg138Gln Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg143Trp Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg198Cys Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg216His Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg331His Single submitter ⚠
- p.Arg381Cys Single submitter ⚠
- p.Arg395Gly Single submitter ⚠
- p.Arg443Cys Single submitter ⚠
- p.Arg53Gln Single submitter ⚠
- p.Arg72Gly Single submitter ⚠
- p.Arg93Pro Single submitter ⚠
- p.Asn90Ser Single submitter ⚠
- p.Asp114Glu Single submitter ⚠
- p.Asp315Asn Single submitter ⚠
- p.Asp417Glu Single submitter ⚠
- p.Asp64His Single submitter ⚠
- p.Asp85His Single submitter
- p.Gln247Arg Single submitter ⚠
- p.Gln358His Single submitter ⚠
- p.Gln371Arg Single submitter ⚠
- p.Glu148Gln Single submitter ⚠
- p.Glu150Lys Single submitter ⚠
- p.Glu308Lys Single submitter ⚠
- p.Gly221Arg Single submitter ⚠
- p.Gly221Asp Single submitter ⚠
- p.Gly234Trp Single submitter ⚠
- p.Gly365Asp Single submitter ⚠
- p.Gly367Arg Single submitter ⚠
- p.Gly369Trp Single submitter ⚠
- p.Gly375Glu Single submitter ⚠
- p.Gly422Arg Single submitter ⚠
- p.Gly44Ser Single submitter ⚠
- p.Gly51Ser Single submitter ⚠
- p.His228Arg Single submitter ⚠
- p.His302Arg Single submitter ⚠
- p.His302Asp Single submitter ⚠
- p.Ile127Val Single submitter ⚠
- p.Ile171Ser Single submitter ⚠
- p.Ile329Met Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Ile444Thr Single submitter ⚠
- p.Leu152Arg Single submitter ⚠
- p.Leu208Phe Single submitter ⚠
- p.Leu260Ile Single submitter ⚠
- p.Leu313Val Single submitter ⚠
- p.Leu318Phe Single submitter ⚠
- p.Leu75Arg Single submitter ⚠
- p.Lys125Glu Single submitter ⚠
- p.Met210Ile Single submitter ⚠
- p.Met291Ile Single submitter ⚠
- p.Phe122Cys Single submitter ⚠
- p.Pro312Ser Single submitter ⚠
- p.Pro343Leu Single submitter ⚠
- p.Ser259Asn Single submitter ⚠
- p.Thr160Ser Single submitter ⚠
- p.Thr287Met Single submitter ⚠
- p.Thr372Arg Single submitter ⚠
- p.Trp166Arg Single submitter ⚠
- p.Tyr144Phe Single submitter ⚠
- p.Tyr281Asn Single submitter ⚠
- p.Tyr303Ser Single submitter ⚠
- p.Tyr426Cys Single submitter ⚠
- p.Tyr426Ser Single submitter ⚠
- p.Tyr62Cys Single submitter ⚠
- p.Tyr86His Single submitter ⚠
- p.Val211Gly Single submitter ⚠
- p.Val238Ile Single submitter ⚠
- p.Val342Ala Single submitter ⚠
- p.Val45Leu Single submitter ⚠
- p.Val65Met Single submitter ⚠