PTPRCAP — 35 ClinVar variants
All ClinVar germline PTPRCAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
3 Likely benign · 32 Uncertain significance
Full PTPRCAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTPRCAP p.Ala137Val Uncertain significance Single submitter
- PTPRCAP p.Ala14Val Uncertain significance Single submitter
- PTPRCAP p.Ala169Val Uncertain significance Single submitter
- PTPRCAP p.Ala182Ser Uncertain significance Single submitter
- PTPRCAP p.Ala193Thr Uncertain significance Single submitter
- PTPRCAP p.Ala73Val Uncertain significance Single submitter
- PTPRCAP p.Arg55His Uncertain significance Single submitter
- PTPRCAP p.Arg56Cys Uncertain significance Single submitter
- PTPRCAP p.Arg59Cys Uncertain significance Single submitter
- PTPRCAP p.Arg69His Uncertain significance Single submitter
- PTPRCAP p.Arg77His Uncertain significance Single submitter
- PTPRCAP p.Arg79Gln Uncertain significance Single submitter
- PTPRCAP p.Arg94Gln Uncertain significance Single submitter
- PTPRCAP p.Asp190Gly Uncertain significance Single submitter
- PTPRCAP p.Glu129Ala Uncertain significance Single submitter
- PTPRCAP p.Gly10Trp Uncertain significance Single submitter
- PTPRCAP p.Gly128Arg Uncertain significance Single submitter
- PTPRCAP p.Gly157Ser Uncertain significance Single submitter
- PTPRCAP p.Gly198Val Uncertain significance Single submitter
- PTPRCAP p.Gly98Ala Uncertain significance Single submitter
- PTPRCAP p.Leu74Pro Uncertain significance Single submitter
- PTPRCAP p.Leu9Phe Uncertain significance Single submitter
- PTPRCAP p.Pro87Leu Uncertain significance Single submitter
- PTPRCAP p.Ser138Phe Uncertain significance Single submitter
- PTPRCAP p.Ser172Asn Uncertain significance Single submitter
- PTPRCAP p.Thr155Met Uncertain significance Single submitter
- PTPRCAP p.Val118Ile Uncertain significance Single submitter
- PTPRCAP p.Val36Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All PTPRCAP variants
Likely benign 3
- p.Arg106Gln Single submitter
- p.Arg146Gln Single submitter
- p.Gly162Ser Single submitter
Uncertain significance 32
- p.Ala137Val Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala169Val Single submitter ⚠
- p.Ala182Ser Single submitter ⚠
- p.Ala193Thr Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg55His Single submitter ⚠
- p.Arg56Cys Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg69His Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Arg79Gln Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg94Gln Single submitter ⚠
- p.Asp190Gly Single submitter ⚠
- p.Glu129Ala Single submitter ⚠
- p.Gly10Trp Single submitter ⚠
- p.Gly128Arg Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly198Val Single submitter ⚠
- p.Gly98Ala Single submitter ⚠
- p.Leu74Pro Single submitter ⚠
- p.Leu9Phe Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Ser138Phe Single submitter ⚠
- p.Ser172Asn Single submitter ⚠
- p.Thr155Met Single submitter ⚠
- p.Trp75Arg Single submitter ⚠
- p.Trp75Cys Single submitter ⚠
- p.Val118Ile Single submitter ⚠
- p.Val36Ile Single submitter ⚠