PTPRF — 356 ClinVar variants
All ClinVar germline PTPRF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 247 flagged for review →
1 Pathogenic · 1 Likely pathogenic · 22 Benign · 5 Benign/Likely benign · 68 Likely benign · 259 Uncertain significance
Full PTPRF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 247
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 171
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 171
- PTPRF p.Gly1143Ser Uncertain significance Multiple submitters
-
PTPRF p.His1730Gln
Uncertain significance
Multiple submitters
breasts and/or nipples, aplasia or hypoplasia of, 2
- PTPRF p.Ala1021Thr Uncertain significance Single submitter
- PTPRF p.Ala1065Thr Uncertain significance Single submitter
- PTPRF p.Ala1494Thr Uncertain significance Single submitter
- PTPRF p.Ala1638Thr Uncertain significance Single submitter
- PTPRF p.Ala178Gly Uncertain significance Single submitter
- PTPRF p.Ala25Thr Uncertain significance Single submitter
- PTPRF p.Ala27Thr Uncertain significance Single submitter
- PTPRF p.Ala493Val Uncertain significance Single submitter
- PTPRF p.Ala770Pro Uncertain significance Single submitter
- PTPRF p.Ala770Thr Uncertain significance Single submitter
- PTPRF p.Ala863Val Uncertain significance Single submitter
- PTPRF p.Arg1115His Uncertain significance Single submitter
- PTPRF p.Arg1178Gln Uncertain significance Single submitter
- PTPRF p.Arg1182His Uncertain significance Single submitter
- PTPRF p.Arg1207Trp Uncertain significance Single submitter
- PTPRF p.Arg1317Trp Uncertain significance Single submitter
- PTPRF p.Arg1451Trp Uncertain significance Single submitter
- PTPRF p.Arg1467His Uncertain significance Single submitter
- PTPRF p.Arg1507His Uncertain significance Single submitter
- PTPRF p.Arg150Cys Uncertain significance Single submitter
- PTPRF p.Arg1532Trp Uncertain significance Single submitter
- PTPRF p.Arg1587Ser Uncertain significance Single submitter
- PTPRF p.Arg1742Trp Uncertain significance Single submitter
- PTPRF p.Arg188His Uncertain significance Single submitter
- PTPRF p.Arg229Cys Uncertain significance Single submitter
- PTPRF p.Arg282His Uncertain significance Single submitter
- PTPRF p.Arg292His Uncertain significance Single submitter
- PTPRF p.Arg355Cys Uncertain significance Single submitter
- PTPRF p.Arg405Trp Uncertain significance Single submitter
- PTPRF p.Arg407His Uncertain significance Single submitter
- PTPRF p.Arg456His Uncertain significance Single submitter
- PTPRF p.Arg585His Uncertain significance Single submitter
- PTPRF p.Arg685Gln Uncertain significance Single submitter
- PTPRF p.Arg750Gln Uncertain significance Single submitter
- PTPRF p.Arg773Gln Uncertain significance Single submitter
- PTPRF p.Arg773Trp Uncertain significance Single submitter
- PTPRF p.Arg77His Uncertain significance Single submitter
- PTPRF p.Arg808His Uncertain significance Single submitter
- PTPRF p.Arg823Gln Uncertain significance Single submitter
- PTPRF p.Arg854Gln Uncertain significance Single submitter
- PTPRF p.Arg891Gln Uncertain significance Single submitter
- PTPRF p.Arg897Gly Uncertain significance Single submitter
- PTPRF p.Arg92Gln Uncertain significance Single submitter
- PTPRF p.Arg956Gln Uncertain significance Single submitter
- PTPRF p.Asn1049Asp Uncertain significance Single submitter
- PTPRF p.Asn295Ser Uncertain significance Single submitter
- PTPRF p.Asn466His Uncertain significance Single submitter
- PTPRF p.Asn466Thr Uncertain significance Single submitter
- PTPRF p.Asn866Asp Uncertain significance Single submitter
- PTPRF p.Asp1098Asn Uncertain significance Single submitter
- PTPRF p.Asp1160Asn Uncertain significance Single submitter
- PTPRF p.Asp1192Asn Uncertain significance Single submitter
- PTPRF p.Asp1296Asn Uncertain significance Single submitter
- PTPRF p.Asp1404Gly Uncertain significance Single submitter
- PTPRF p.Asp779Asn Uncertain significance Single submitter
- PTPRF p.Asp874Val Uncertain significance Single submitter
- PTPRF p.Cys107Gly Uncertain significance Single submitter
- PTPRF p.Gln1173Arg Uncertain significance Single submitter
- PTPRF p.Gln1249Arg Uncertain significance Single submitter
- PTPRF p.Gln353Arg Uncertain significance Single submitter
- PTPRF p.Gln519Lys Uncertain significance Single submitter
- PTPRF p.Glu1155Lys Uncertain significance Single submitter
- PTPRF p.Glu1167Lys Uncertain significance Single submitter
- PTPRF p.Glu1677Lys Uncertain significance Single submitter
- PTPRF p.Glu270Lys Uncertain significance Single submitter
- PTPRF p.Glu360Gly Uncertain significance Single submitter
- PTPRF p.Glu4Val Uncertain significance Single submitter
- PTPRF p.Glu570Gly Uncertain significance Single submitter
- PTPRF p.Glu652Lys Uncertain significance Single submitter
- PTPRF p.Glu755Lys Uncertain significance Single submitter
- PTPRF p.Glu963Ala Uncertain significance Single submitter
- PTPRF p.Gly1114Ser Uncertain significance Single submitter
- PTPRF p.Gly1144Arg Uncertain significance Single submitter
- PTPRF p.Gly1402Arg Uncertain significance Single submitter
- PTPRF p.Gly1425Ala Uncertain significance Single submitter
- PTPRF p.Gly1518Glu Uncertain significance Single submitter
- PTPRF p.Gly1611Val Uncertain significance Single submitter
- PTPRF p.Gly1628Ser Uncertain significance Single submitter
- PTPRF p.Gly470Glu Uncertain significance Single submitter
- PTPRF p.Gly651Ser Uncertain significance Single submitter
- PTPRF p.Gly655Glu Uncertain significance Single submitter
- PTPRF p.Gly881Ser Uncertain significance Single submitter
- PTPRF p.Gly946Arg Uncertain significance Single submitter
- PTPRF p.His1122Tyr Uncertain significance Single submitter
- PTPRF p.His1290Arg Uncertain significance Single submitter
- PTPRF p.His1652Gln Uncertain significance Single submitter
- PTPRF p.His465Pro Uncertain significance Single submitter
- PTPRF p.His666Arg Uncertain significance Single submitter
- PTPRF p.Ile1111Thr Uncertain significance Single submitter
- PTPRF p.Ile1111Val Uncertain significance Single submitter
- PTPRF p.Ile1334Val Uncertain significance Single submitter
- PTPRF p.Ile1359Val Uncertain significance Single submitter
- PTPRF p.Ile1735Val Uncertain significance Single submitter
- PTPRF p.Ile868Val Uncertain significance Single submitter
- PTPRF p.Ile958Leu Uncertain significance Single submitter
- PTPRF p.Leu1147Met Uncertain significance Single submitter
- PTPRF p.Leu1276Ile Uncertain significance Single submitter
- PTPRF p.Leu318Pro Uncertain significance Single submitter
- PTPRF p.Lys1062Arg Uncertain significance Single submitter
- PTPRF p.Lys1184Arg Uncertain significance Single submitter
- PTPRF p.Lys844Glu Uncertain significance Single submitter
- PTPRF p.Met1146Val Uncertain significance Single submitter
- PTPRF p.Met1232Thr Uncertain significance Single submitter
- PTPRF p.Met154Ile Uncertain significance Single submitter
- PTPRF p.Met1726Val Uncertain significance Single submitter
- PTPRF p.Met266Val Uncertain significance Single submitter
- PTPRF p.Met424Thr Uncertain significance Single submitter
- PTPRF p.Met542Thr Uncertain significance Single submitter
- PTPRF p.Met67Leu Uncertain significance Single submitter
- PTPRF p.Met833Thr Uncertain significance Single submitter
- PTPRF p.Phe1511Leu Uncertain significance Single submitter
- PTPRF p.Phe973Ile Uncertain significance Single submitter
- PTPRF p.Pro1009Leu Uncertain significance Single submitter
- PTPRF p.Pro1009Thr Uncertain significance Single submitter
- PTPRF p.Pro1216Leu Uncertain significance Single submitter
- PTPRF p.Pro1631Ser Uncertain significance Single submitter
- PTPRF p.Pro16Leu Uncertain significance Single submitter
- PTPRF p.Pro1768Leu Uncertain significance Single submitter
- PTPRF p.Pro1809Leu Uncertain significance Single submitter
- PTPRF p.Pro400Ala Uncertain significance Single submitter
- PTPRF p.Pro501Ser Uncertain significance Single submitter
- PTPRF p.Pro536Ala Uncertain significance Single submitter
- PTPRF p.Pro563Leu Uncertain significance Single submitter
- PTPRF p.Pro712Leu Uncertain significance Single submitter
- PTPRF p.Ser1059Leu Uncertain significance Single submitter
- PTPRF p.Ser1498Thr Uncertain significance Single submitter
- PTPRF p.Ser1585Ala Uncertain significance Single submitter
- PTPRF p.Ser167Tyr Uncertain significance Single submitter
- PTPRF p.Ser180Gly Uncertain significance Single submitter
- PTPRF p.Ser293Phe Uncertain significance Single submitter
- PTPRF p.Ser344Leu Uncertain significance Single submitter
- PTPRF p.Ser344Pro Uncertain significance Single submitter
- PTPRF p.Ser643Thr Uncertain significance Single submitter
- PTPRF p.Ser696Arg Uncertain significance Single submitter
- PTPRF p.Ser950Thr Uncertain significance Single submitter
- PTPRF p.Thr10Arg Uncertain significance Single submitter
- PTPRF p.Thr10Met Uncertain significance Single submitter
- PTPRF p.Thr1148Met Uncertain significance Single submitter
- PTPRF p.Thr1785Met Uncertain significance Single submitter
- PTPRF p.Thr179Met Uncertain significance Single submitter
- PTPRF p.Thr1907Ala Uncertain significance Single submitter
- PTPRF p.Thr330Ala Uncertain significance Single submitter
- PTPRF p.Thr348Asn Uncertain significance Single submitter
- PTPRF p.Thr560Ile Uncertain significance Single submitter
- PTPRF p.Thr788Ile Uncertain significance Single submitter
- PTPRF p.Thr802Ala Uncertain significance Single submitter
- PTPRF p.Thr817Ala Uncertain significance Single submitter
- PTPRF p.Thr825Ala Uncertain significance Single submitter
Predictors split 76
The independent predictors disagree with each other — read with care.
- PTPRF p.Ala1022Ser Uncertain significance Single submitter
- PTPRF p.Ala152Gly Uncertain significance Single submitter
- PTPRF p.Ala1894Val Uncertain significance Single submitter
- PTPRF p.Arg1115Cys Uncertain significance Single submitter
- PTPRF p.Arg1141Cys Uncertain significance Single submitter
- PTPRF p.Arg1175Gln Uncertain significance Single submitter
- PTPRF p.Arg1175Trp Uncertain significance Single submitter
- PTPRF p.Arg1182Cys Uncertain significance Single submitter
- PTPRF p.Arg1212Trp Uncertain significance Single submitter
- PTPRF p.Arg1343Cys Uncertain significance Single submitter
- PTPRF p.Arg1504Cys Uncertain significance Single submitter
- PTPRF p.Arg1531Gln Likely benign Single submitter
- PTPRF p.Arg1532Gln Uncertain significance Single submitter
- PTPRF p.Arg1757His Uncertain significance Single submitter
- PTPRF p.Arg1780His Uncertain significance Single submitter
- PTPRF p.Arg229His Uncertain significance Single submitter
- PTPRF p.Arg388His Uncertain significance Single submitter
- PTPRF p.Arg407Ser Uncertain significance Single submitter
- PTPRF p.Arg456Cys Uncertain significance Single submitter
- PTPRF p.Arg600Cys Uncertain significance Single submitter
- PTPRF p.Arg654Cys Uncertain significance Single submitter
- PTPRF p.Arg750Trp Uncertain significance Single submitter
- PTPRF p.Arg989His Uncertain significance Single submitter
- PTPRF p.Asn1347Ser Uncertain significance Single submitter
- PTPRF p.Asn1619Tyr Uncertain significance Single submitter
- PTPRF p.Asn636Ser Uncertain significance Single submitter
- PTPRF p.Asp1336Asn Uncertain significance Single submitter
- PTPRF p.Asp138Asn Uncertain significance Single submitter
- PTPRF p.Asp985His Uncertain significance Single submitter
- PTPRF p.Gln1462Arg Uncertain significance Single submitter
- PTPRF p.Gln1462Glu Uncertain significance Single submitter
- PTPRF p.Gln1684His Uncertain significance Single submitter
- PTPRF p.Gln411His Uncertain significance Single submitter
- PTPRF p.Gln745Leu Uncertain significance Single submitter
- PTPRF p.Glu106Asp Uncertain significance Single submitter
- PTPRF p.Glu1342Lys Uncertain significance Single submitter
- PTPRF p.Glu647Lys Uncertain significance Single submitter
- PTPRF p.Glu963Lys Uncertain significance Single submitter
- PTPRF p.Gly1057Glu Uncertain significance Single submitter
- PTPRF p.Gly1301Arg Uncertain significance Single submitter
- PTPRF p.Gly1499Ala Uncertain significance Single submitter
- PTPRF p.Gly1611Ser Uncertain significance Single submitter
- PTPRF p.Gly1702Ser Uncertain significance Single submitter
- PTPRF p.Gly786Val Uncertain significance Single submitter
- PTPRF p.Ile1406Val Uncertain significance Single submitter
- PTPRF p.Ile1559Val Uncertain significance Single submitter
- PTPRF p.Leu577His Uncertain significance Single submitter
- PTPRF p.Leu934Val Uncertain significance Single submitter
- PTPRF p.Lys1016Arg Uncertain significance Single submitter
- PTPRF p.Lys1351Thr Uncertain significance Single submitter
- PTPRF p.Lys1416Gln Uncertain significance Single submitter
- PTPRF p.Lys1667Arg Uncertain significance Single submitter
- PTPRF p.Lys884Asn Uncertain significance Single submitter
- PTPRF p.Met1544Thr Uncertain significance Single submitter
- PTPRF p.Met1769Thr Uncertain significance Single submitter
- PTPRF p.Phe1666Leu Uncertain significance Single submitter
- PTPRF p.Pro1662Ser Uncertain significance Single submitter
- PTPRF p.Pro1775Thr Uncertain significance Single submitter
- PTPRF p.Pro220Ser Uncertain significance Single submitter
- PTPRF p.Pro346Ala Uncertain significance Single submitter
- PTPRF p.Pro698Leu Uncertain significance Single submitter
- PTPRF p.Ser1031Gly Uncertain significance Single submitter
- PTPRF p.Ser1082Arg Uncertain significance Single submitter
- PTPRF p.Ser1310Phe Uncertain significance Single submitter
- PTPRF p.Ser31Arg Uncertain significance Single submitter
- PTPRF p.Ser383Leu Uncertain significance Single submitter
- PTPRF p.Thr153Ile Uncertain significance Single submitter
- PTPRF p.Thr1851Ser Uncertain significance Single submitter
- PTPRF p.Thr273Ser Uncertain significance Single submitter
- PTPRF p.Thr467Pro Uncertain significance Single submitter
- PTPRF p.Trp548Cys Uncertain significance Single submitter
- PTPRF p.Val1374Leu Uncertain significance Single submitter
- PTPRF p.Val701Leu Uncertain significance Single submitter
- PTPRF p.Val879Ala Uncertain significance Single submitter
- PTPRF p.Val953Met Uncertain significance Single submitter
-
PTPRF p.Tyr450Cys
Benign
No assertion criteria
PTPRF-related disorder
All PTPRF variants
Pathogenic 1
- p.Val616fs No assertion criteria breasts and/or nipples, aplasia or hypoplasia of, 2
Likely pathogenic 1
- p.Lys320fs Single submitter breasts and/or nipples, aplasia or hypoplasia of, 2
Benign 22
- c.237+5G>A Multiple submitters
- c.3974-9C>T Multiple submitters
- p.Ala1659= Multiple submitters
- p.Ala602= Multiple submitters
- p.Ala942Val Multiple submitters
- p.Phe78= Multiple submitters
- c.1668+9C>T Single submitter
- c.3135+20A>G Single submitter
- c.4072-6C>T Single submitter
- p.Ala1513= Single submitter
- p.Ala1607= Single submitter
- p.Ala221= Single submitter
- p.Arg1436= Single submitter
- p.Arg1504= Single submitter
- p.Arg635Cys Single submitter
- p.Gly1432= Single submitter
- p.Pro842= Single submitter
- p.Tyr1861= Single submitter
- p.Val1137= Single submitter
- p.Ala157= No assertion criteria PTPRF-related disorder
- p.Asp562Asn No assertion criteria PTPRF-related disorder
- p.Tyr450Cys No assertion criteria PTPRF-related disorder ⚠
Benign/Likely benign 5
- c.1531+9G>A Multiple submitters
- c.1668+10G>C Multiple submitters
- p.Pro1292= Multiple submitters
- p.Thr1712= Multiple submitters
- p.Thr371= Multiple submitters
Likely benign 68
- p.Ala356Ser Multiple submitters
- p.Arg1893His Multiple submitters
- p.Gln1889Arg Multiple submitters
- p.Pro708= Multiple submitters
- p.Thr1637= Multiple submitters
- c.1531+12C>A Single submitter
- c.1531+18G>A Single submitter
- c.2119+16G>A Single submitter
- c.3135+6dup Single submitter
- c.3483+3A>G Single submitter
- c.3703-10C>T Single submitter
- c.4072-11A>G Single submitter
- p.Ala549= Single submitter
- p.Ala648= Single submitter
- p.Arg1531Gln Single submitter ⚠
- p.Arg419= Single submitter
- p.Arg579His Single submitter
- p.Asn1205Ser Single submitter
- p.Asp1540= Single submitter
- p.Glu903= Single submitter
- p.Gly26= Single submitter
- p.Gly589= Single submitter
- p.Gly901= Single submitter
- p.His1579= Single submitter
- p.His726Arg Single submitter
- p.Ile1275= Single submitter
- p.Ile1359= Single submitter
- p.Ile541Val Single submitter
- p.Leu1047= Single submitter
- p.Leu125= Single submitter
- p.Leu1506Val Single submitter
- p.Leu855= Single submitter
- p.Pro1267= Single submitter
- p.Pro459Leu Single submitter
- p.Pro609= Single submitter
- p.Ser1549= Single submitter
- p.Ser212= Single submitter
- p.Ser524= Single submitter
- p.Ser785= Single submitter
- p.Thr1395= Single submitter
- p.Thr1469= Single submitter
- p.Thr1593= Single submitter
- p.Thr703= Single submitter
- p.Thr886Ala Single submitter
- p.Thr925Ile Single submitter
- p.Tyr1387= Single submitter
- p.Tyr262= Single submitter
- p.Val1400= Single submitter
- p.Val638Ile Single submitter
- c.3389+4T>G No assertion criteria PTPRF-related disorder
- c.3974-829C>T No assertion criteria PTPRF-related disorder
- c.4372-7C>T No assertion criteria PTPRF-related disorder
- p.Arg1286= No assertion criteria PTPRF-related disorder
- p.Asn441= No assertion criteria PTPRF-related disorder
- p.Asp650= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
- p.Ile1819= No assertion criteria PTPRF-related disorder
- p.Leu1641= No assertion criteria PTPRF-related disorder
- p.Leu846= No assertion criteria PTPRF-related disorder
- p.Lys1626= No assertion criteria PTPRF-related disorder
- p.Lys37= No assertion criteria PTPRF-related disorder
- p.Phe1044= No assertion criteria PTPRF-related disorder
- p.Pro399Leu No assertion criteria PTPRF-related disorder
- p.Pro459= No assertion criteria PTPRF-related disorder
- p.Ser1654= No assertion criteria PTPRF-related disorder
- p.Ser607= No assertion criteria PTPRF-related disorder
- p.Ser607Thr No assertion criteria PTPRF-related disorder
- p.Thr1265= No assertion criteria PTPRF-related disorder
- p.Thr880= No assertion criteria PTPRF-related disorder
Uncertain significance 259
- p.Gly1143Ser Multiple submitters ⚠
- p.His1730Gln Multiple submitters breasts and/or nipples, aplasia or hypoplasia of, 2 ⚠
- p.Ala1021Thr Single submitter ⚠
- p.Ala1022Ser Single submitter ⚠
- p.Ala1065Thr Single submitter ⚠
- p.Ala1494Thr Single submitter ⚠
- p.Ala152Gly Single submitter ⚠
- p.Ala1638Thr Single submitter ⚠
- p.Ala178Gly Single submitter ⚠
- p.Ala1894Val Single submitter ⚠
- p.Ala25Thr Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala493Val Single submitter ⚠
- p.Ala770Pro Single submitter ⚠
- p.Ala770Thr Single submitter ⚠
- p.Ala863Val Single submitter ⚠
- p.Arg1115Cys Single submitter ⚠
- p.Arg1115His Single submitter ⚠
- p.Arg1141Cys Single submitter ⚠
- p.Arg1175Gln Single submitter ⚠
- p.Arg1175Trp Single submitter ⚠
- p.Arg1178Gln Single submitter ⚠
- p.Arg1182Cys Single submitter ⚠
- p.Arg1182His Single submitter ⚠
- p.Arg1207Trp Single submitter ⚠
- p.Arg1212Trp Single submitter ⚠
- p.Arg1317Gln Single submitter
- p.Arg1317Trp Single submitter ⚠
- p.Arg1343Cys Single submitter ⚠
- p.Arg1451Trp Single submitter ⚠
- p.Arg1467His Single submitter ⚠
- p.Arg1504Cys Single submitter ⚠
- p.Arg1507His Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg1532Gln Single submitter ⚠
- p.Arg1532Trp Single submitter ⚠
- p.Arg1587Ser Single submitter ⚠
- p.Arg1742Trp Single submitter ⚠
- p.Arg1757His Single submitter ⚠
- p.Arg1780His Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg229His Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg292His Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg388His Single submitter ⚠
- p.Arg405Trp Single submitter ⚠
- p.Arg407His Single submitter ⚠
- p.Arg407Ser Single submitter ⚠
- p.Arg456Cys Single submitter ⚠
- p.Arg456His Single submitter ⚠
- p.Arg487Cys Single submitter
- p.Arg585His Single submitter ⚠
- p.Arg600Cys Single submitter ⚠
- p.Arg654Cys Single submitter ⚠
- p.Arg685Gln Single submitter ⚠
- p.Arg750Gln Single submitter ⚠
- p.Arg750Trp Single submitter ⚠
- p.Arg773Gln Single submitter ⚠
- p.Arg773Trp Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Arg808His Single submitter ⚠
- p.Arg823Gln Single submitter ⚠
- p.Arg854Gln Single submitter ⚠
- p.Arg859Trp Single submitter
- p.Arg891Gln Single submitter ⚠
- p.Arg897Gly Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Arg956Gln Single submitter ⚠
- p.Arg956Leu Single submitter
- p.Arg989His Single submitter ⚠
- p.Asn1049Asp Single submitter ⚠
- p.Asn1347Ser Single submitter ⚠
- p.Asn1619Tyr Single submitter ⚠
- p.Asn295Ser Single submitter ⚠
- p.Asn466His Single submitter ⚠
- p.Asn466Thr Single submitter ⚠
- p.Asn636Ser Single submitter ⚠
- p.Asn866Asp Single submitter ⚠
- p.Asp1098Asn Single submitter ⚠
- p.Asp1160Asn Single submitter ⚠
- p.Asp1192Asn Single submitter ⚠
- p.Asp1296Asn Single submitter ⚠
- p.Asp1336Asn Single submitter ⚠
- p.Asp138Asn Single submitter ⚠
- p.Asp1404Gly Single submitter ⚠
- p.Asp496Asn Single submitter
- p.Asp779Asn Single submitter ⚠
- p.Asp84Gly Single submitter
- p.Asp874Val Single submitter ⚠
- p.Asp985His Single submitter ⚠
- p.Cys107Gly Single submitter ⚠
- p.Gln1173Arg Single submitter ⚠
- p.Gln1249Arg Single submitter ⚠
- p.Gln1462Arg Single submitter ⚠
- p.Gln1462Glu Single submitter ⚠
- p.Gln1684His Single submitter ⚠
- p.Gln353Arg Single submitter ⚠
- p.Gln411His Single submitter ⚠
- p.Gln519Lys Single submitter ⚠
- p.Gln581Ter Single submitter
- p.Gln745Leu Single submitter ⚠
- p.Glu106Asp Single submitter ⚠
- p.Glu1155Lys Single submitter ⚠
- p.Glu1167Lys Single submitter ⚠
- p.Glu1342Lys Single submitter ⚠
- p.Glu1677Lys Single submitter ⚠
- p.Glu270Lys Single submitter ⚠
- p.Glu360Gly Single submitter ⚠
- p.Glu4Val Single submitter ⚠
- p.Glu570Gly Single submitter ⚠
- p.Glu647Lys Single submitter ⚠
- p.Glu652Lys Single submitter ⚠
- p.Glu755Lys Single submitter ⚠
- p.Glu963Ala Single submitter ⚠
- p.Glu963Lys Single submitter ⚠
- p.Gly1057Glu Single submitter ⚠
- p.Gly1114Ser Single submitter ⚠
- p.Gly1144Arg Single submitter ⚠
- p.Gly1301Arg Single submitter ⚠
- p.Gly1402Arg Single submitter ⚠
- p.Gly1425Ala Single submitter ⚠
- p.Gly1499Ala Single submitter ⚠
- p.Gly1518Glu Single submitter ⚠
- p.Gly1611Ser Single submitter ⚠
- p.Gly1611Val Single submitter ⚠
- p.Gly1628Ser Single submitter ⚠
- p.Gly1702Ser Single submitter ⚠
- p.Gly470Glu Single submitter ⚠
- p.Gly651Ser Single submitter ⚠
- p.Gly655Glu Single submitter ⚠
- p.Gly786Val Single submitter ⚠
- p.Gly881Ser Single submitter ⚠
- p.Gly901Ser Single submitter
- p.Gly946Arg Single submitter ⚠
- p.His1122Tyr Single submitter ⚠
- p.His1290Arg Single submitter ⚠
- p.His1652Gln Single submitter ⚠
- p.His465Pro Single submitter ⚠
- p.His666Arg Single submitter ⚠
- p.Ile1111Thr Single submitter ⚠
- p.Ile1111Val Single submitter ⚠
- p.Ile1334Val Single submitter ⚠
- p.Ile1359Val Single submitter ⚠
- p.Ile1406Val Single submitter ⚠
- p.Ile1559Val Single submitter ⚠
- p.Ile1735Val Single submitter ⚠
- p.Ile868Val Single submitter ⚠
- p.Ile958Leu Single submitter ⚠
- p.Leu1147Met Single submitter ⚠
- p.Leu1276Ile Single submitter ⚠
- p.Leu1641Phe Single submitter
- p.Leu318Pro Single submitter ⚠
- p.Leu577His Single submitter ⚠
- p.Leu934Val Single submitter ⚠
- p.Lys1016Arg Single submitter ⚠
- p.Lys1062Arg Single submitter ⚠
- p.Lys1184Arg Single submitter ⚠
- p.Lys1351Thr Single submitter ⚠
- p.Lys1416Gln Single submitter ⚠
- p.Lys1667Arg Single submitter ⚠
- p.Lys844Glu Single submitter ⚠
- p.Lys884Asn Single submitter ⚠
- p.Met1146Val Single submitter ⚠
- p.Met1232Thr Single submitter ⚠
- p.Met1544Thr Single submitter ⚠
- p.Met154Ile Single submitter ⚠
- p.Met1583Leu Single submitter
- p.Met1726Val Single submitter ⚠
- p.Met1769Thr Single submitter ⚠
- p.Met266Val Single submitter ⚠
- p.Met424Thr Single submitter ⚠
- p.Met542Thr Single submitter ⚠
- p.Met67Leu Single submitter ⚠
- p.Met833Thr Single submitter ⚠
- p.Phe1511Leu Single submitter ⚠
- p.Phe1666Leu Single submitter ⚠
- p.Phe973Ile Single submitter ⚠
- p.Pro1009Leu Single submitter ⚠
- p.Pro1009Thr Single submitter ⚠
- p.Pro1216Leu Single submitter ⚠
- p.Pro1631Ser Single submitter ⚠
- p.Pro1662Ser Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro1768Leu Single submitter ⚠
- p.Pro1775Thr Single submitter ⚠
- p.Pro1809Leu Single submitter ⚠
- p.Pro220Ser Single submitter ⚠
- p.Pro346Ala Single submitter ⚠
- p.Pro400Ala Single submitter ⚠
- p.Pro501Ser Single submitter ⚠
- p.Pro536Ala Single submitter ⚠
- p.Pro563Leu Single submitter ⚠
- p.Pro698Leu Single submitter ⚠
- p.Pro712Leu Single submitter ⚠
- p.Ser1031Gly Single submitter ⚠
- p.Ser1059Leu Single submitter ⚠
- p.Ser1082Arg Single submitter ⚠
- p.Ser1310Phe Single submitter ⚠
- p.Ser1498Thr Single submitter ⚠
- p.Ser1585Ala Single submitter ⚠
- p.Ser167Tyr Single submitter ⚠
- p.Ser180Gly Single submitter ⚠
- p.Ser180Ile Single submitter
- p.Ser293Phe Single submitter ⚠
- p.Ser31Arg Single submitter ⚠
- p.Ser344Leu Single submitter ⚠
- p.Ser344Pro Single submitter ⚠
- p.Ser383Leu Single submitter ⚠
- p.Ser643Thr Single submitter ⚠
- p.Ser696Arg Single submitter ⚠
- p.Ser950Thr Single submitter ⚠
- p.Thr10Arg Single submitter ⚠
- p.Thr10Met Single submitter ⚠
- p.Thr1148Met Single submitter ⚠
- p.Thr153Ile Single submitter ⚠
- p.Thr1785Met Single submitter ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr1851Ser Single submitter ⚠
- p.Thr1907Ala Single submitter ⚠
- p.Thr273Ser Single submitter ⚠
- p.Thr330Ala Single submitter ⚠
- p.Thr348Asn Single submitter ⚠
- p.Thr467Pro Single submitter ⚠
- p.Thr560Ile Single submitter ⚠
- p.Thr788Ile Single submitter ⚠
- p.Thr802Ala Single submitter ⚠
- p.Thr817Ala Single submitter ⚠
- p.Thr825Ala Single submitter ⚠
- p.Thr887Ala Single submitter ⚠
- p.Trp548Cys Single submitter ⚠
- p.Tyr1488Asn Single submitter ⚠
- p.Tyr1488His Single submitter ⚠
- p.Tyr1621His Single submitter ⚠
- p.Tyr262Cys Single submitter ⚠
- p.Val1193Met Single submitter ⚠
- p.Val1224Leu Single submitter ⚠
- p.Val1247Met Single submitter ⚠
- p.Val1268Met Single submitter ⚠
- p.Val1374Leu Single submitter ⚠
- p.Val1490Leu Single submitter
- p.Val1552Leu Single submitter ⚠
- p.Val1636Met Single submitter ⚠
- p.Val19Met Single submitter ⚠
- p.Val249Met Single submitter
- p.Val254Met Single submitter ⚠
- p.Val263Met Single submitter ⚠
- p.Val326Met Single submitter ⚠
- p.Val38Phe Single submitter ⚠
- p.Val449Ile Single submitter ⚠
- p.Val475Met Single submitter
- p.Val616Met Single submitter ⚠
- p.Val701Leu Single submitter ⚠
- p.Val749Met Single submitter ⚠
- p.Val879Ala Single submitter ⚠
- p.Val953Met Single submitter ⚠
- p.Val98Leu Single submitter ⚠
- p.Arg1176Trp No assertion criteria ⚠