PTPRR — 100 ClinVar variants
All ClinVar germline PTPRR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 94 flagged for review →
1 Benign · 3 Likely benign · 96 Uncertain significance
Full PTPRR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 94
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PTPRR p.Ala295Thr Uncertain significance Single submitter
- PTPRR p.Ala318Thr Uncertain significance Single submitter
- PTPRR p.Ala388Thr Uncertain significance Single submitter
- PTPRR p.Ala577Gly Uncertain significance Single submitter
- PTPRR p.Ala616Val Uncertain significance Single submitter
- PTPRR p.Ala653Thr Uncertain significance Single submitter
- PTPRR p.Ala89Thr Uncertain significance Single submitter
- PTPRR p.Arg134Trp Uncertain significance Single submitter
- PTPRR p.Arg137Cys Uncertain significance Single submitter
- PTPRR p.Arg137His Uncertain significance Single submitter
- PTPRR p.Arg172Gln Uncertain significance Single submitter
- PTPRR p.Arg187His Uncertain significance Single submitter
- PTPRR p.Arg308Gln Uncertain significance Single submitter
- PTPRR p.Arg380Lys Uncertain significance Single submitter
- PTPRR p.Arg581Gln Uncertain significance Single submitter
- PTPRR p.Arg77Cys Uncertain significance Single submitter
- PTPRR p.Asn154Ser Uncertain significance Single submitter
- PTPRR p.Asn211Lys Uncertain significance Single submitter
- PTPRR p.Asn25Asp Uncertain significance Single submitter
- PTPRR p.Asn340Ser Uncertain significance Single submitter
- PTPRR p.Asp124Asn Uncertain significance Single submitter
- PTPRR p.Asp385Asn Uncertain significance Single submitter
- PTPRR p.Asp55Asn Uncertain significance Single submitter
- PTPRR p.Cys11Trp Uncertain significance Single submitter
- PTPRR p.Gln277His Uncertain significance Single submitter
- PTPRR p.Gln294Arg Uncertain significance Single submitter
- PTPRR p.Gln34Glu Uncertain significance Single submitter
- PTPRR p.Glu183Lys Uncertain significance Single submitter
- PTPRR p.Glu282Gln Uncertain significance Single submitter
- PTPRR p.Glu282Gly Uncertain significance Single submitter
- PTPRR p.Gly101Cys Uncertain significance Single submitter
- PTPRR p.His217Arg Uncertain significance Single submitter
- PTPRR p.His270Gln Uncertain significance Single submitter
- PTPRR p.His287Leu Uncertain significance Single submitter
- PTPRR p.His28Asp Uncertain significance Single submitter
- PTPRR p.His543Arg Uncertain significance Single submitter
- PTPRR p.His543Leu Uncertain significance Single submitter
- PTPRR p.His642Gln Uncertain significance Single submitter
- PTPRR p.Ile111Val Uncertain significance Single submitter
- PTPRR p.Ile130Met Uncertain significance Single submitter
- PTPRR p.Ile130Val Uncertain significance Single submitter
- PTPRR p.Ile135Leu Uncertain significance Single submitter
- PTPRR p.Ile157Thr Uncertain significance Single submitter
- PTPRR p.Ile170Met Uncertain significance Single submitter
- PTPRR p.Ile191Val Uncertain significance Single submitter
- PTPRR p.Ile241Val Uncertain significance Single submitter
- PTPRR p.Ile331Met Uncertain significance Single submitter
- PTPRR p.Ile331Thr Uncertain significance Single submitter
- PTPRR p.Ile331Val Uncertain significance Single submitter
- PTPRR p.Ile377Phe Uncertain significance Single submitter
- PTPRR p.Ile377Thr Uncertain significance Single submitter
- PTPRR p.Ile50Thr Uncertain significance Single submitter
- PTPRR p.Ile56Thr Uncertain significance Single submitter
- PTPRR p.Leu104Phe Uncertain significance Single submitter
- PTPRR p.Leu189Phe Uncertain significance Single submitter
- PTPRR p.Leu213Ser Uncertain significance Single submitter
- PTPRR p.Leu280Pro Uncertain significance Single submitter
- PTPRR p.Leu518Arg Uncertain significance Single submitter
- PTPRR p.Leu54Arg Uncertain significance Single submitter
- PTPRR p.Lys127Asn Uncertain significance Single submitter
- PTPRR p.Lys210Asn Uncertain significance Single submitter
- PTPRR p.Lys297Glu Uncertain significance Single submitter
- PTPRR p.Lys45Asn Uncertain significance Single submitter
- PTPRR p.Lys508Arg Uncertain significance Single submitter
- PTPRR p.Phe7Leu Uncertain significance Single submitter
- PTPRR p.Pro169Ser Uncertain significance Single submitter
- PTPRR p.Pro273Leu Uncertain significance Single submitter
- PTPRR p.Pro325Ser Uncertain significance Single submitter
- PTPRR p.Pro558Ser Uncertain significance Single submitter
- PTPRR p.Pro58Leu Uncertain significance Single submitter
- PTPRR p.Ser258Phe Uncertain significance Single submitter
- PTPRR p.Ser272Leu Uncertain significance Single submitter
- PTPRR p.Ser358Phe Uncertain significance Single submitter
- PTPRR p.Ser375Arg Uncertain significance Single submitter
- PTPRR p.Ser395Gly Uncertain significance Single submitter
- PTPRR p.Ser539Arg Uncertain significance Single submitter
- PTPRR p.Ser649Arg Uncertain significance Single submitter
- PTPRR p.Ser75Arg Uncertain significance Single submitter
- PTPRR p.Thr440Asn Uncertain significance Single submitter
- PTPRR p.Tyr455Phe Uncertain significance Single submitter
- PTPRR p.Val212Ile Uncertain significance Single submitter
- PTPRR p.Val303Ala Uncertain significance Single submitter
- PTPRR p.Val387Leu Uncertain significance Single submitter
- PTPRR p.Val387Met Uncertain significance Single submitter
- PTPRR p.Val405Ala Uncertain significance Single submitter
- PTPRR p.Val584Met Uncertain significance Single submitter
- PTPRR p.Val81Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PTPRR p.Ala367Glu Uncertain significance Single submitter
- PTPRR p.Arg155Cys Benign Single submitter
- PTPRR p.Glu611Gly Uncertain significance Single submitter
- PTPRR p.Leu345Ser Uncertain significance Single submitter
- PTPRR p.Met630Leu Uncertain significance Single submitter
- PTPRR p.Pro413Leu Uncertain significance Single submitter
- PTPRR p.Val620Phe Uncertain significance Single submitter
All PTPRR variants
Benign 1
- p.Arg155Cys Single submitter ⚠
Likely benign 3
- p.Cys6Gly Single submitter
- p.Ser70= Single submitter
- p.Tyr249His Single submitter
Uncertain significance 96
- p.Ala295Thr Single submitter ⚠
- p.Ala318Thr Single submitter ⚠
- p.Ala367Glu Single submitter ⚠
- p.Ala388Thr Single submitter ⚠
- p.Ala461Asp Single submitter
- p.Ala577Gly Single submitter ⚠
- p.Ala616Val Single submitter ⚠
- p.Ala653Thr Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg172Gln Single submitter ⚠
- p.Arg187His Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg380Lys Single submitter ⚠
- p.Arg581Gln Single submitter ⚠
- p.Arg77Cys Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asn211Lys Single submitter ⚠
- p.Asn25Asp Single submitter ⚠
- p.Asn340Ser Single submitter ⚠
- p.Asp124Asn Single submitter ⚠
- p.Asp385Asn Single submitter ⚠
- p.Asp55Asn Single submitter ⚠
- p.Cys11Trp Single submitter ⚠
- p.Gln277His Single submitter ⚠
- p.Gln294Arg Single submitter ⚠
- p.Gln34Glu Single submitter ⚠
- p.Glu183Lys Single submitter ⚠
- p.Glu282Gln Single submitter ⚠
- p.Glu282Gly Single submitter ⚠
- p.Glu611Gly Single submitter ⚠
- p.Gly101Cys Single submitter ⚠
- p.His217Arg Single submitter ⚠
- p.His270Gln Single submitter ⚠
- p.His287Leu Single submitter ⚠
- p.His28Asp Single submitter ⚠
- p.His543Arg Single submitter ⚠
- p.His543Leu Single submitter ⚠
- p.His641Tyr Single submitter
- p.His642Gln Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile130Met Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile135Leu Single submitter ⚠
- p.Ile157Thr Single submitter ⚠
- p.Ile170Met Single submitter ⚠
- p.Ile191Val Single submitter ⚠
- p.Ile241Val Single submitter ⚠
- p.Ile331Met Single submitter ⚠
- p.Ile331Thr Single submitter ⚠
- p.Ile331Val Single submitter ⚠
- p.Ile377Phe Single submitter ⚠
- p.Ile377Thr Single submitter ⚠
- p.Ile50Thr Single submitter ⚠
- p.Ile56Thr Single submitter ⚠
- p.Leu104Phe Single submitter ⚠
- p.Leu189Phe Single submitter ⚠
- p.Leu213Ser Single submitter ⚠
- p.Leu280Pro Single submitter ⚠
- p.Leu345Ser Single submitter ⚠
- p.Leu518Arg Single submitter ⚠
- p.Leu54Arg Single submitter ⚠
- p.Lys127Asn Single submitter ⚠
- p.Lys210Asn Single submitter ⚠
- p.Lys297Glu Single submitter ⚠
- p.Lys45Asn Single submitter ⚠
- p.Lys508Arg Single submitter ⚠
- p.Met630Leu Single submitter ⚠
- p.Phe7Leu Single submitter ⚠
- p.Pro169Ser Single submitter ⚠
- p.Pro273Leu Single submitter ⚠
- p.Pro325Ser Single submitter ⚠
- p.Pro413Leu Single submitter ⚠
- p.Pro558Ser Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Ser258Phe Single submitter ⚠
- p.Ser272Leu Single submitter ⚠
- p.Ser358Phe Single submitter ⚠
- p.Ser375Arg Single submitter ⚠
- p.Ser395Gly Single submitter ⚠
- p.Ser539Arg Single submitter ⚠
- p.Ser649Arg Single submitter ⚠
- p.Ser75Arg Single submitter ⚠
- p.Thr440Asn Single submitter ⚠
- p.Thr550Asn Single submitter
- p.Tyr455Phe Single submitter ⚠
- p.Val212Ile Single submitter ⚠
- p.Val303Ala Single submitter ⚠
- p.Val387Leu Single submitter ⚠
- p.Val387Met Single submitter ⚠
- p.Val405Ala Single submitter ⚠
- p.Val584Met Single submitter ⚠
- p.Val620Phe Single submitter ⚠
- p.Val81Ile Single submitter ⚠