PURB — 32 ClinVar variants
All ClinVar germline PURB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
32 Uncertain significance
Full PURB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- PURB p.Ala109Asp Uncertain significance Single submitter
- PURB p.Ala22Val Uncertain significance Single submitter
- PURB p.Ala271Thr Uncertain significance Single submitter
- PURB p.Asp89Gly Uncertain significance Single submitter
- PURB p.Gln20Pro Uncertain significance Single submitter
- PURB p.Glu127Lys Uncertain significance Single submitter
- PURB p.Glu199Asp Uncertain significance Single submitter
- PURB p.Gly11Asp Uncertain significance Single submitter
- PURB p.Gly203Val Uncertain significance Single submitter
- PURB p.Gly210Ser Uncertain significance Single submitter
- PURB p.Gly214Ala Uncertain significance Single submitter
- PURB p.Gly214Asp Uncertain significance Single submitter
- PURB p.Gly26Asp Uncertain significance Single submitter
- PURB p.Gly26Ser Uncertain significance Single submitter
- PURB p.Gly297Val Uncertain significance Single submitter
- PURB p.Gly306Ser Uncertain significance Single submitter
- PURB p.His93Tyr Uncertain significance Single submitter
- PURB p.Ile41Asn Uncertain significance Single submitter
- PURB p.Lys130Arg Uncertain significance Single submitter
- PURB p.Pro115Ser Uncertain significance Single submitter
- PURB p.Pro161Leu Uncertain significance Single submitter
- PURB p.Pro161Ser Uncertain significance Single submitter
- PURB p.Pro204Leu Uncertain significance Single submitter
- PURB p.Pro21Ser Uncertain significance Single submitter
- PURB p.Thr74Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- PURB p.Glu9Lys Uncertain significance Single submitter
- PURB p.Gly162Arg Uncertain significance Single submitter
- PURB p.Gly162Trp Uncertain significance Single submitter
- PURB p.Gly203Cys Uncertain significance Single submitter
- PURB p.Gly209Trp Uncertain significance Single submitter
- PURB p.Lys289Met Uncertain significance Single submitter
- PURB p.Ser71Asn Uncertain significance Single submitter
All PURB variants
Uncertain significance 32
- p.Ala109Asp Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala271Thr Single submitter ⚠
- p.Asp89Gly Single submitter ⚠
- p.Gln20Pro Single submitter ⚠
- p.Glu127Lys Single submitter ⚠
- p.Glu199Asp Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly11Asp Single submitter ⚠
- p.Gly162Arg Single submitter ⚠
- p.Gly162Trp Single submitter ⚠
- p.Gly203Cys Single submitter ⚠
- p.Gly203Val Single submitter ⚠
- p.Gly209Trp Single submitter ⚠
- p.Gly210Ser Single submitter ⚠
- p.Gly214Ala Single submitter ⚠
- p.Gly214Asp Single submitter ⚠
- p.Gly26Asp Single submitter ⚠
- p.Gly26Ser Single submitter ⚠
- p.Gly297Val Single submitter ⚠
- p.Gly306Ser Single submitter ⚠
- p.His93Tyr Single submitter ⚠
- p.Ile41Asn Single submitter ⚠
- p.Lys130Arg Single submitter ⚠
- p.Lys289Met Single submitter ⚠
- p.Pro115Ser Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro161Ser Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro21Ser Single submitter ⚠
- p.Ser71Asn Single submitter ⚠
- p.Thr74Met Single submitter ⚠