QPCT — 71 ClinVar variants
All ClinVar germline QPCT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 2 Likely benign · 68 Uncertain significance
Full QPCT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- QPCT p.Ala203Pro Uncertain significance Single submitter
- QPCT p.Ala224Val Uncertain significance Single submitter
- QPCT p.Ala232Glu Uncertain significance Single submitter
- QPCT p.Arg118Gln Uncertain significance Single submitter
- QPCT p.Arg172Cys Uncertain significance Single submitter
- QPCT p.Arg172His Uncertain significance Single submitter
- QPCT p.Arg217Gln Uncertain significance Single submitter
- QPCT p.Arg233Ser Uncertain significance Single submitter
- QPCT p.Arg27Gly Uncertain significance Single submitter
- QPCT p.Arg7Trp Uncertain significance Single submitter
- QPCT p.Asp175Glu Uncertain significance Single submitter
- QPCT p.Asp211Gly Uncertain significance Single submitter
- QPCT p.Asp211Val Uncertain significance Single submitter
- QPCT p.Asp306Glu Uncertain significance Single submitter
- QPCT p.Glu105Gln Uncertain significance Single submitter
- QPCT p.Glu290Gln Uncertain significance Single submitter
- QPCT p.Glu64Gly Uncertain significance Single submitter
- QPCT p.Gly231Ala Uncertain significance Single submitter
- QPCT p.Gly231Arg Uncertain significance Single submitter
- QPCT p.Gly234Ser Uncertain significance Single submitter
- QPCT p.Gly28Arg Uncertain significance Single submitter
- QPCT p.His14Tyr Uncertain significance Single submitter
- QPCT p.His307Arg Uncertain significance Single submitter
- QPCT p.Ile250Val Uncertain significance Single submitter
- QPCT p.Ile350Val Uncertain significance Single submitter
- QPCT p.Ile75Thr Uncertain significance Single submitter
- QPCT p.Leu13Val Uncertain significance Single submitter
- QPCT p.Leu15Val Uncertain significance Single submitter
- QPCT p.Leu219Ser Uncertain significance Single submitter
- QPCT p.Leu98Phe Uncertain significance Single submitter
- QPCT p.Lys40Thr Uncertain significance Single submitter
- QPCT p.Met166Arg Uncertain significance Single submitter
- QPCT p.Met167Ile Uncertain significance Single submitter
- QPCT p.Met332Val Uncertain significance Single submitter
- QPCT p.Phe260Val Uncertain significance Single submitter
- QPCT p.Pro114Arg Uncertain significance Single submitter
- QPCT p.Pro129Ser Uncertain significance Single submitter
- QPCT p.Pro227Leu Uncertain significance Single submitter
- QPCT p.Pro230Arg Uncertain significance Single submitter
- QPCT p.Pro258His Uncertain significance Single submitter
- QPCT p.Ser119Tyr Uncertain significance Single submitter
- QPCT p.Ser225Leu Uncertain significance Single submitter
- QPCT p.Ser34Leu Uncertain significance Single submitter
- QPCT p.Thr108Asn Uncertain significance Single submitter
- QPCT p.Thr113Pro Uncertain significance Single submitter
- QPCT p.Thr183Ser Uncertain significance Single submitter
- QPCT p.Thr256Ala Uncertain significance Single submitter
- QPCT p.Trp329Arg Uncertain significance Single submitter
- QPCT p.Val103Ala Uncertain significance Single submitter
- QPCT p.Val153Glu Uncertain significance Single submitter
- QPCT p.Val315Ile Uncertain significance Single submitter
- QPCT p.Val353Ile Uncertain significance Single submitter
- QPCT p.Val9Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- QPCT p.Ala21Asp Uncertain significance Single submitter
- QPCT p.Arg88Cys Uncertain significance Single submitter
- QPCT p.Leu16Gln Uncertain significance Single submitter
- QPCT p.Leu311Phe Uncertain significance Single submitter
- QPCT p.Phe261Ile Uncertain significance Single submitter
- QPCT p.Pro229Leu Uncertain significance Single submitter
- QPCT p.Pro316Ala Uncertain significance Single submitter
- QPCT p.Thr343Ala Uncertain significance Single submitter
- QPCT p.Tyr115Cys Uncertain significance Single submitter
All QPCT variants
Benign 1
- p.Val353Ala Single submitter
Likely benign 2
- p.Arg292Gln Single submitter
- p.Ser61Asn Single submitter
Uncertain significance 68
- p.Ala203Pro Single submitter ⚠
- p.Ala21Asp Single submitter ⚠
- p.Ala224Val Single submitter ⚠
- p.Ala232Glu Single submitter ⚠
- p.Arg118Gln Single submitter ⚠
- p.Arg172Cys Single submitter ⚠
- p.Arg172His Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg233Ser Single submitter ⚠
- p.Arg270Thr Single submitter
- p.Arg27Gly Single submitter ⚠
- p.Arg7Trp Single submitter ⚠
- p.Arg88Cys Single submitter ⚠
- p.Asp175Glu Single submitter ⚠
- p.Asp211Gly Single submitter ⚠
- p.Asp211Val Single submitter ⚠
- p.Asp306Glu Single submitter ⚠
- p.Glu105Gln Single submitter ⚠
- p.Glu290Gln Single submitter ⚠
- p.Glu64Gly Single submitter ⚠
- p.Gly231Ala Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly28Arg Single submitter ⚠
- p.His14Tyr Single submitter ⚠
- p.His307Arg Single submitter ⚠
- p.Ile250Val Single submitter ⚠
- p.Ile303Thr Single submitter
- p.Ile350Val Single submitter ⚠
- p.Ile75Thr Single submitter ⚠
- p.Leu13Val Single submitter ⚠
- p.Leu15Val Single submitter ⚠
- p.Leu16Gln Single submitter ⚠
- p.Leu219Ser Single submitter ⚠
- p.Leu311Phe Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys40Thr Single submitter ⚠
- p.Met166Arg Single submitter ⚠
- p.Met166Ile Single submitter
- p.Met167Ile Single submitter ⚠
- p.Met332Val Single submitter ⚠
- p.Phe260Val Single submitter ⚠
- p.Phe261Ile Single submitter ⚠
- p.Pro114Arg Single submitter ⚠
- p.Pro129Ser Single submitter ⚠
- p.Pro227Leu Single submitter ⚠
- p.Pro229Leu Single submitter ⚠
- p.Pro230Arg Single submitter ⚠
- p.Pro258His Single submitter ⚠
- p.Pro309Ala Single submitter
- p.Pro316Ala Single submitter ⚠
- p.Ser119Tyr Single submitter ⚠
- p.Ser225Leu Single submitter ⚠
- p.Ser34Leu Single submitter ⚠
- p.Thr108Asn Single submitter ⚠
- p.Thr113Pro Single submitter ⚠
- p.Thr183Ser Single submitter ⚠
- p.Thr256Ala Single submitter ⚠
- p.Thr343Ala Single submitter ⚠
- p.Trp329Arg Single submitter ⚠
- p.Tyr115Cys Single submitter ⚠
- p.Tyr145Cys Single submitter
- p.Val103Ala Single submitter ⚠
- p.Val153Glu Single submitter ⚠
- p.Val162Met Single submitter
- p.Val315Ile Single submitter ⚠
- p.Val353Ile Single submitter ⚠
- p.Val9Ile Single submitter ⚠