QPCTL — 78 ClinVar variants
All ClinVar germline QPCTL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
1 Benign · 3 Likely benign · 74 Uncertain significance
Full QPCTL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- QPCTL p.Ala212Glu Uncertain significance Single submitter
- QPCTL p.Ala213Gly Uncertain significance Single submitter
- QPCTL p.Ala354Val Uncertain significance Single submitter
- QPCTL p.Ala377Asp Uncertain significance Single submitter
- QPCTL p.Arg10Cys Uncertain significance Single submitter
- QPCTL p.Arg284Cys Uncertain significance Single submitter
- QPCTL p.Arg284His Uncertain significance Single submitter
- QPCTL p.Arg284Pro Uncertain significance Single submitter
- QPCTL p.Arg287His Uncertain significance Single submitter
- QPCTL p.Arg28Cys Uncertain significance Single submitter
- QPCTL p.Arg28Gly Uncertain significance Single submitter
- QPCTL p.Arg301His Uncertain significance Single submitter
- QPCTL p.Arg333His Uncertain significance Single submitter
- QPCTL p.Arg370His Uncertain significance Single submitter
- QPCTL p.Arg69Leu Uncertain significance Single submitter
- QPCTL p.Arg82Gln Uncertain significance Single submitter
- QPCTL p.Asn150Tyr Uncertain significance Single submitter
- QPCTL p.Asn303Asp Uncertain significance Single submitter
- QPCTL p.Asp186His Uncertain significance Single submitter
- QPCTL p.Asp202Asn Uncertain significance Single submitter
- QPCTL p.Asp326Gly Uncertain significance Single submitter
- QPCTL p.Gln114His Uncertain significance Single submitter
- QPCTL p.Glu230Asp Uncertain significance Single submitter
- QPCTL p.Glu248Lys Uncertain significance Single submitter
- QPCTL p.Glu263Asp Uncertain significance Single submitter
- QPCTL p.Glu319Lys Uncertain significance Single submitter
- QPCTL p.Glu357Lys Uncertain significance Single submitter
- QPCTL p.Glu61Gly Uncertain significance Single submitter
- QPCTL p.Gly129Asp Uncertain significance Single submitter
- QPCTL p.Gly239Ser Uncertain significance Single submitter
- QPCTL p.Gly5Val Uncertain significance Single submitter
- QPCTL p.Gly74Arg Uncertain significance Single submitter
- QPCTL p.His168Arg Uncertain significance Single submitter
- QPCTL p.His300Arg Uncertain significance Single submitter
- QPCTL p.Ile342Ser Uncertain significance Single submitter
- QPCTL p.Ile342Thr Uncertain significance Single submitter
- QPCTL p.Ile371Val Uncertain significance Single submitter
- QPCTL p.Leu13Arg Uncertain significance Single submitter
- QPCTL p.Leu194Met Uncertain significance Single submitter
- QPCTL p.Leu203Val Uncertain significance Single submitter
- QPCTL p.Leu222Val Uncertain significance Single submitter
- QPCTL p.Leu228Met Uncertain significance Single submitter
- QPCTL p.Leu264Phe Uncertain significance Single submitter
- QPCTL p.Leu368Ser Uncertain significance Single submitter
- QPCTL p.Phe137Ile Uncertain significance Single submitter
- QPCTL p.Pro274Ser Uncertain significance Single submitter
- QPCTL p.Pro309Thr Uncertain significance Single submitter
- QPCTL p.Pro337Ser Uncertain significance Single submitter
- QPCTL p.Ser178Leu Uncertain significance Single submitter
- QPCTL p.Ser46Trp Uncertain significance Single submitter
- QPCTL p.Thr356Asn Uncertain significance Single submitter
- QPCTL p.Thr50Asn Uncertain significance Single submitter
- QPCTL p.Trp55Arg Uncertain significance Single submitter
- QPCTL p.Val44Leu Uncertain significance Single submitter
- QPCTL p.Val70Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- QPCTL p.Ala159Asp Uncertain significance Single submitter
- QPCTL p.Ala273Val Uncertain significance Single submitter
- QPCTL p.Arg124Trp Uncertain significance Single submitter
- QPCTL p.Arg287Cys Uncertain significance Single submitter
- QPCTL p.Arg291Trp Uncertain significance Single submitter
- QPCTL p.Arg370Cys Uncertain significance Single submitter
- QPCTL p.Gly232Glu Uncertain significance Single submitter
- QPCTL p.His361Tyr Uncertain significance Single submitter
- QPCTL p.Leu42Arg Uncertain significance Single submitter
- QPCTL p.Pro254Arg Uncertain significance Single submitter
- QPCTL p.Thr122Met Uncertain significance Single submitter
- QPCTL p.Thr257Ile Uncertain significance Single submitter
- QPCTL p.Thr364Met Likely benign Single submitter
- QPCTL p.Val146Glu Uncertain significance Single submitter
- QPCTL p.Val146Gly Uncertain significance Single submitter
- QPCTL p.Val151Met Uncertain significance Single submitter
All QPCTL variants
Benign 1
- p.Arg161His Multiple submitters
Likely benign 3
- p.Asn303= Single submitter
- p.Thr344= Single submitter
- p.Thr364Met Single submitter ⚠
Uncertain significance 74
- p.Ala159Asp Single submitter ⚠
- p.Ala212Glu Single submitter ⚠
- p.Ala213Gly Single submitter ⚠
- p.Ala273Val Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Ala377Asp Single submitter ⚠
- p.Arg10Cys Single submitter ⚠
- p.Arg124Trp Single submitter ⚠
- p.Arg284Cys Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg284Pro Single submitter ⚠
- p.Arg287Cys Single submitter ⚠
- p.Arg287His Single submitter ⚠
- p.Arg28Cys Single submitter ⚠
- p.Arg28Gly Single submitter ⚠
- p.Arg291Trp Single submitter ⚠
- p.Arg301His Single submitter ⚠
- p.Arg333His Single submitter ⚠
- p.Arg370Cys Single submitter ⚠
- p.Arg370His Single submitter ⚠
- p.Arg69Leu Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Asn150Tyr Single submitter ⚠
- p.Asn303Asp Single submitter ⚠
- p.Asp186His Single submitter ⚠
- p.Asp202Asn Single submitter ⚠
- p.Asp326Gly Single submitter ⚠
- p.Gln114His Single submitter ⚠
- p.Glu230Asp Single submitter ⚠
- p.Glu248Lys Single submitter ⚠
- p.Glu263Asp Single submitter ⚠
- p.Glu319Lys Single submitter ⚠
- p.Glu357Lys Single submitter ⚠
- p.Glu61Gly Single submitter ⚠
- p.Gly129Asp Single submitter ⚠
- p.Gly232Glu Single submitter ⚠
- p.Gly239Ser Single submitter ⚠
- p.Gly5Val Single submitter ⚠
- p.Gly74Arg Single submitter ⚠
- p.His168Arg Single submitter ⚠
- p.His300Arg Single submitter ⚠
- p.His361Tyr Single submitter ⚠
- p.Ile342Ser Single submitter ⚠
- p.Ile342Thr Single submitter ⚠
- p.Ile371Val Single submitter ⚠
- p.Leu13Arg Single submitter ⚠
- p.Leu194Met Single submitter ⚠
- p.Leu203Val Single submitter ⚠
- p.Leu222Val Single submitter ⚠
- p.Leu228Met Single submitter ⚠
- p.Leu264Phe Single submitter ⚠
- p.Leu368Ser Single submitter ⚠
- p.Leu42Arg Single submitter ⚠
- p.Phe137Ile Single submitter ⚠
- p.Pro107Leu Single submitter
- p.Pro254Arg Single submitter ⚠
- p.Pro274Ser Single submitter ⚠
- p.Pro309Thr Single submitter ⚠
- p.Pro337Ser Single submitter ⚠
- p.Ser109Cys Single submitter
- p.Ser178Leu Single submitter ⚠
- p.Ser46Trp Single submitter ⚠
- p.Thr122Met Single submitter ⚠
- p.Thr164Asn Single submitter
- p.Thr257Ile Single submitter ⚠
- p.Thr352Ile Single submitter
- p.Thr356Asn Single submitter ⚠
- p.Thr50Asn Single submitter ⚠
- p.Trp55Arg Single submitter ⚠
- p.Val146Glu Single submitter ⚠
- p.Val146Gly Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val44Leu Single submitter ⚠
- p.Val70Ile Single submitter ⚠